Renal effects of general anesthesia from old to recent studies

Alizadeh, Reza; Fard, Ziba Aghsaie

doi:10.1002/jcp.28407

Cited by 27 publications

(12 citation statements)

References 144 publications

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“…For cesarean section anesthesia, subarachnoid or epidural injection of local anesthetics such as bupivacaine or ropivacaine or opioids is often the option of choice [ 5 ]. On this basis, adjuvant systemic sedative drugs may help to improve the effect of anesthesia and reduce the occurrence of adverse reactions [ 26 ]. Dexmedetomidine is an auxiliary sedative commonly used in clinical practice and is also widely used in cesarean section anesthesia.…”

Section: Discussionmentioning

confidence: 99%

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

Pang

Zhu

Yan

et al. 2022

BioMed Research International

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Objective. To evaluate the anesthetic effect and safety of dexmedetomidine in cesarean section. Methods. The Cochrane Library, EMBASE, and PubMed databases (established until September 2020) were searched by computer. Two authors independently screened and extracted literature related to the application of dexmedetomidine in the cesarean section according to inclusion and exclusion criteria. The control group received either subarachnoid block (lumbar anesthesia) or combined lumbar anesthesia and epidural anesthesia (combined lumbar epidural anesthesia) with bupivacaine or combined bupivacaine and fentanyl. The observation group was additionally given dexmedetomidine based on the control group, to analyze the anesthetic effect and safety of dexmedetomidine in cesarean section. Results. A total of 580 cesarean delivery women were included in 8 studies, and the results showed that the peak time of sensory block in the observation group was shorter than that in the control group (standard mean difference = − 0.28 ; 95% confidence interval: -0.48, -0.08; P = 0.006 ), sensory block lasted longer than that in the control group (standard mean difference = 1.49 ; 95% confidence interval: 1.21, 1.78; P < 0.00001 ), the sedation rate was higher than that in the control group, the onset of the first postoperative pain was significantly delayed compared with that in the control group, and the incidence of postoperative pain, nausea and vomiting, postoperative chills, and fever was lower than that in the control group ( P < 0.05 ). Conclusion. Dexmedetomidine combined with lumbar anesthesia or combined lumbar epidural anesthesia for women in cesarean section has more clinical benefits and better safety.

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Section: Discussionmentioning

confidence: 99%

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

Pang

Zhu

Yan

et al. 2022

BioMed Research International

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“…Symptomatic hypocalcemia is usually seen 24–48 hours after the surgery. In order to prevent hypocalcemia, prolonged hospitalization and further complications, calcium and vitamin D are usually given as supplements preoperatively or postoperatively [ 14 ]. In order to avoid the excessive intake of these supplements, prediction of factors that can lead to hypocalcemia is significant [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Hypocalcemia following total and subtotal thyroidectomy and associated factors

Azadbakht

Emadi-jamali

Azadbakht

2021

Annals of Medicine &Amp; Surgery

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Background Thyroidectomy is one of the common endocrinological surgeries for the treatment of thyroid disorders. Hypocalcemia is the potential complication after thyroidectomy, where is persistency can lead to serious systemic effects. The aim of this study is to evaluate the incidence of hypocalcemia in thyroidectomy patients. Methods In this cross-sectional study, patients referred to (XXX) for thyroidectomy from 2019 to 2020 were enrolled. Preoperative serum calcium and postoperative 24- and 48-h calcium levels were evaluated in these patients. Demographic data (sex and gender), calcium levels, type of thyroidectomy and duration of surgery was recorded for all the patients. SPSS v22 was used for statistical analysis. P < 0.05 was considered as statistically significant. Results Of 143 patients included in the study, the mean age was 49.7 ± 10.9 years and 61.5% were females and 38.5% were males. 49% patients had hypocalcemia in the first 24 hours after surgery and 63.6% following 48 hours of the surgery. The difference in calcium levels at three intervals were statistically significant, p = 0.001. The incidence of hypocalcemia was significantly more in women at 48 postoperative hours, p = 0.025. The age and duration of surgery was not significantly correlated with hypocalcemia, p > 0.05, whereas, patients who underwent total thyroidectomy had greater incidence of hypocalcemia 24 hours after the surgery, p = 0.021. Conclusions The incidence of hypocalcemia is greater in total thyroidectomy and female patients. Our study did not report significant correlation between duration of the surgery and age of the patients.

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“…Disturbances in electrolytes are measurable by biochemical parameters in the bloodstream that determines the clinical manifestations of interactions between metabolic events such as hormones, 8,9 medications, 10 renal physiology, 11,12 sepsis, 13 hydration deficiencies, 14 and vascular events 15 …”

Section: Introductionmentioning

confidence: 99%

“…4,5 The kidney and aldosterone, parathyroid hormone, antidiuretic hormone, and other factors such as physiological stress play important roles in electrolyte balance and regulating fluid in the body. 6,7 Disturbances in electrolytes are measurable by biochemical parameters in the bloodstream that determines the clinical manifestations of interactions between metabolic events such as hormones, 8,9 medications, 10 renal physiology, 11,12 sepsis, 13 hydration deficiencies, 14 and vascular events. 15 Most common electrolyte imbalances are hypo-and hyper-states of potassium, magnesium, sodium, and calcium.…”

mentioning

confidence: 99%

A cross‐sectional study on the prevalence of electrolyte abnormalities in multiple trauma patients in Hamedan, Iran

Rezaei

Ramazani

Amiri

et al. 2021

Health Science Reports

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Introduction Evaluation of electrolyte status and homeostasis is one of the most important components of evaluation and treatment of critically ill patients, especially those with multiple trauma. Electrolyte imbalance can be associated with a bad prognosis and the need of specialized consultancy. Aim The aim of this study was to evaluate and determine the electrolyte status of patients with multiple trauma and evaluate the relationship of electrolyte disorders with patient outcome. Methods In this cross‐sectional study, 370 patients who were referred to the emergency department of Besat Hospital in Hamadan, Iran with multiple trauma were studied. Demographic parameters clinical characteristics such as blood pressure, heart rate, respiratory rate, consciousness score and body temperature, paraclinical characteristics including radiographic status, ultrasound, and electrocardiography and serum levels of sodium, potassium, creatinine, hemoglobin, hematocrit, and BUN and urine analysis was performed. Data regarding the discharge from emergency department or referral to other units were also complete in a questionnaire for each patient. Statistical analyses were performed using SPSSv24. Results Three hundred seventy patients with multiple trauma were studied where 73% of patients were men and 27% were women. One hundred ninety‐six patients were discharged from the emergency department, and 174 patients were referred to other units of the hospital. The most common electrolyte abnormalities were hypotension (62.7%), hypernatremia (9.5%), hypokalemia (6.8%), and hypercreatinine (4.6%). The results of independent t ‐test showed that heart rate and potassium level were significantly higher in patients referred to other units than in patients discharged from the emergency department and respiratory rate and hematocrit were significantly lower in patients referred to other units. Conclusion Hypotension, hypernatremia, hypokalemia, hypercreatinine, and abnormal urine analysis were more frequent in patients referred to other units than in patients discharged from the emergency department. These variables can be considered in predicting patient status for referral to other units and delayed hospital discharge.

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Renal effects of general anesthesia from old to recent studies

Cited by 27 publications

References 144 publications

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

Hypocalcemia following total and subtotal thyroidectomy and associated factors

A cross‐sectional study on the prevalence of electrolyte abnormalities in multiple trauma patients in Hamedan, Iran

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