Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

Dicker, S. E.; Eggleton, M. Grace

doi:10.1113/jphysiol.1961.sp006727

Cited by 31 publications

(8 citation statements)

References 26 publications

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“…The importance of arginine in position 8 has been emphasized in connexion with pressor activity (Katsoyannis & du Vigneaud, 1958) and antidiuresis (Dicker & Eggleton, 1961), and it was therefore of interest to find in the present investigation that the two hormones having arginine in position 8 were by far the most potent in increasing permeability to water. By considering the hydrosmotic potency shown by the different peptides some light may be thrown on whether, as proposed by Rudinger & Jost (1964), it might be the spatial position of the substituent, or, as proposed by Berde, Boissonnas, Huguenin & Sturmer (1964) it might be the basicity of the substituent which determines the permeability effect of the molecule.…”

Section: Discussionmentioning

confidence: 87%

Natriferic and hydrosmotic effects of neurohypophysial peptides and their analogues in augmenting fluid uptake by Bufo melanostictus

Elliott¹

1968

The Journal of Physiology

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4. Dose-response curves for each peptide showed that in the case of 8-arginine vasopressin, 8-lysine vasopressin and 8-ornithine vasopressin the augmentation of rate of fluid uptake did not differ in the absence or in the presence of NaCl in the bathing solution; whereas in the case of 8-arginine vasotocin, oxytocin, and 8-ornithine oxytocin the augmentation was greater in the presence of sodium chloride. 5. Support has been found for the postulate of a binary action of some neurohypophysial peptides on amphibian skin, arginine in position 8 being correlated with hydrosmotic effect, and isoleucine in position 3 with natriferic effect.

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Section: Discussionmentioning

confidence: 87%

Natriferic and hydrosmotic effects of neurohypophysial peptides and their analogues in augmenting fluid uptake by Bufo melanostictus

Elliott¹

1968

The Journal of Physiology

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“…Katsoyannis & du Vigneaud (1959), Dicker & Eggleton (1961) and Sawyer, Chan & van Dyke (1962) have shown that the variations of antidiuretic and pressor potencies of the neurohypophyseal hormones and their analogues can be related to the degree of basicity of the amino acid in position 8, as well as to the specificity of that in position 3. It was, therefore, of interest to see whether a similar relation between molecular configuration and activity would obtain with the present preparation.…”

Section: Resultsmentioning

confidence: 99%

An Isolated Preparation With a Selective Sensitivity to Vasopressin

Botting¹

1965

British Journal of Pharmacology and Chemotherapy

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Reports in the literature have shown that extracts of the posterior pituitary gland with pressor activity increase movement of the gut in some, but not all, species. The fraction with oxytocic activity, however, either has no effect on this tissue or, if any, produces relaxation.In an attempt to find an isolated preparation which would be selectively sensitive to vasopressin, portions of the guinea-pig gut were tested serially, and it was found that the most proximal portion of the colon fulfilled this requirement. METHODSMale guinea-pigs, body weight 320 to 350 g, were starved overnight and killed by stunning and bleeding. The bulbous, proximal portion of the colon, which as an anatomical entity probably corresponds to the sacculus rotundus in other animals ( Fig. 1), was excised and suspended in an organ-bath of 5 ml. capacity. A loop was tied through the distal end, and a thread from the rounded proximal end was attached to a

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“…Breakdown of hyaluronic acid should thus be accompanied by release of Ca. It is known that Ca excretion increases following vasopressin administration in dogs and rats (Thorn, 1960(Thorn, , 1961 and in normal humans (Dicker & Eggleton, 1961) but not those suffering from nephrogenic diabetes insipidus (Dicker & Eggleton, 1963). Ca excretion during spontaneous hydropenia has not previously been studied in rats.…”

Section: R 0 Law and D Rowen Discussionmentioning

confidence: 99%

The influence of hyaluronidase on urinary and renal medullary composition following antidiuretic stimulus in the rat.

Law¹,

Rowen²

1981

The Journal of Physiology

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SUMMARY1. The influence of urinary hyaluronidase (believed to be predominantly of renal origin) on the urinary concentrating process has been studied in rats subjected to antidiuretic stimulus.2. Antiserum against a partially purified preparation of this enzyme has been raised in rabbits. Urinary volume, solute excretion and medullary composition have been investigated in rats treated with this antiserum (0-2 ml./100 g body weight, i.v.) before water deprivation for 48 hr or infusion for up to 4 hr with arginine-vasopressin. Control rats were pre-treated with normal rabbit serum.3. Pre-treatment with antiserum against rat urinary hyaluronidase (AUase) caused water-deprived rats to excrete urine at a rate significantly greater, and of osmolality significantly lower, than that recorded in control rats.4. The increase in medullary solute gradient which typically accompanies antidiuresis was significantly reduced in water-deprived rats pre-treated with AUase.5. In rats treated with AUase and infused for 4 hr with arginine-vasopressin, there was no significant increase in the medullary solute gradient, whereas this increased markedly in control rats. 6. During the first 24 hr of water deprivation there was an increase in the rate of Ca excretion by control rats which was abolished by pre-treatment with AUase.7. The effects of antiserum against a partially purified preparation of rat testicular hyaluronidase (ATase) were studied in water-deprived rats. No evidence was obtained that this enzyme has any influence on renal function. 8. It is concluded that urinary hyaluronidase, but not testicular hyaluronidase, plays an important role in facilitating the urinary concentrating process following antidiuretic stimulus.

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Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

Cited by 31 publications

References 26 publications

Natriferic and hydrosmotic effects of neurohypophysial peptides and their analogues in augmenting fluid uptake by Bufo melanostictus

Natriferic and hydrosmotic effects of neurohypophysial peptides and their analogues in augmenting fluid uptake by Bufo melanostictus

An Isolated Preparation With a Selective Sensitivity to Vasopressin

The influence of hyaluronidase on urinary and renal medullary composition following antidiuretic stimulus in the rat.

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