Renal function adaptation up to the fifth decade after treatment of children with unilateral renal tumor: A cross-sectional and longitudinal study

Abstract

Aging is associated with a mild-to-moderate renal function loss in many adult patients following nephrectomy during childhood for URT.

Minimally invasive nephrectomy for Wilms tumors in children – data from SIOP 2001

“…Recent studies indicate that NSS in unilateral WT is associated with a comparable oncological outcome as classical tumor nephrectomies [24][25][26]. At the same time there is growing evidence that late effects after tumor nephrectomy result in renal failure to a relevant degree; this seems not as much to be the case after NSS in unilateral WT [26][27][28][29][30]. The discussion process within the surgical panel of the SIOP RTSG therefore resulted in the recommendation that MIS and NSS should not interfere in terms of surgical approach: If feasible according to the guidelines of the SIOP Wilms Tumor protocol [31], NSS should be performed.…”

Renal function in patients with Wilms tumor

“…Finally, children treated for WT are usually very young and the prevalence of severe renal dysfunction owing to multifactorial causes is likely to increase with longer follow-up than what is currently available. Cozzi et al [14] demonstrated a significant reduction in estimated GFR in the fifth decade of life in a group of WT survivors that underwent nephrectomy compared with healthy controls.…”

Sonographic Image of Solitary Kidney in Wilms Tumour Survivors

“…We believe this is an open question. Although current NKF guidelines do not recognize SFK as a structural abnormality [6], several studies suggest that SFK is a risk factor for the progression of CKD [44,55,56]. Kolvek et al demonstrated that a substantial proportion of children with SFK developed renal injury defined as hypertension, severely increased albuminuria and a significantly impaired eGFR and/or use of antihypertensive or antiproteinuric medications during childhood (median age 11,0 years).…”