Renal function in patients with diabetic foot infection; does antibiotherapy affect it?

Akbari, Roghayeh; Javaniyan, Mostafa; Fahimi, Amir; Sadeghi, Mahmood

doi:10.15171/jrip.2017.23

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…Akbari et al in a study investigated the effect of anti-biotherapy on renal function. They evaluated 142 patients and found that GFR contributed to renal function and it was reduced in children treated by antibiotics (14), which is similar to the current findings. Also, Wolf et al in their study found that impaired renal function was higher in infections of diabetic foot (15).…”

Section: Discussionsupporting

confidence: 86%

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

et al. 2018

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Background: Infection and its treatment as a common problem in children may induce different complications. Ampicillin and aminoglycosides, as choice drugs for this condition, may have many important side effects, such as nephrotoxic side effects. Therefore, the aim of this study was to evaluate the nephrotoxic effect of gentamicin and amikacin in neonates with infection. Methods: This clinical trial and double blind study was conducted on 80 children with aminoglycosides addministration. Initially, during hospital admission, serum and urine samples were collected for diagnosis of infection. Children based on their treatment were divided to 2 groups, 40 children were treated by ampicillin and amikacin and 40 children were treated by ampicillin and gentamicin, during a 7-day period. At the end of the treatment period, serum and urine samples were taken for measurment of laboratory variables, and GFR, for evaluation of kidney function. Results: Blood Urea Nitrogen (BUN), creatinine and GFR before and after treatment in the two groups did not have statistically significant differences (P > 0.05). In addition age, gender, birth age, infection type, occupation, and education of parents and milk type were equal in the 2 groups. Conclusions: Based on the present study, there were no significant differences between nephrotoxic effect of gentamicin and amikacin in the two groups.

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Section: Discussionsupporting

confidence: 86%

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

et al. 2018

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“…Systemic antibiotic therapy is known to have toxic effects on renal function with significant reduction in estimated glomerular filtration rate (eGFR) [ 32 ]. Four (10%) patients from this case review were identified to develop acute kidney injury (AKI) ( Table 3 and Table 12 ).…”

Section: Discussionmentioning

confidence: 99%

Variation in Systemic Antibiotic Treatment for Diabetic Foot Osteomyelitis in England and Wales: A Multi-Centre Case Review

Uddin,

Russell,

Game

et al. 2024

JCM

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Background: Diabetic foot osteomyelitis (DFO) is a major complication and can lead to significant morbidity and mortality. Systemic antibiotic therapy is often initiated first line to achieve quiescence of infection. To perform a multi-centre case review of systemic antibiotic intervention to treat adults with DFO in England and Wales and compare with national guidelines ‘Diabetic foot problems: prevention and management’. Methods: Eight centres from England and Wales retrospectively collated data from a minimum of five adults (aged ≥ 18 years) from electronic case records. All patients were treated with systemic antibiotics following a new diagnosis of DFO (1 June 2021–31 December 2021). Results: 40 patients (35 males and 5 females) were included; the mean age was 62.3 years (standard deviation (SD) 13.0). Patients commenced systemic oral 14 (35%) or intravenous 26 (65%) antibiotic therapy following a new diagnosis of DFO. Twenty-seven (67.5%) patients were medically or surgically managed in the 12-week period with clinical quiescence of infection. Twenty-one patients (52.5%) had no recurrence of DFO infection within 12 weeks; seventeen (42.5%) of these patients had clinical quiescence of infection with systemic antibiotics alone without surgical intervention and nine (22.5%) of these cases had no recurrence of DFO. There were no cases of major amputation or death. All centres showed significant in-centre variability in systemic antibiotic management; variability was reported in the clinical and quantity indicators specifically to antibiotic selection, single versus dual therapy, mode of delivery and duration of treatment. Conclusions: This case review identifies there is existing variation when treating adults with systemic antibiotics for DFO. Further national guidance is required to standardise service delivery and care to improve patient outcomes.

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“…Several medicinal plants such as Galega officinalis, in addition to producing positive effects on glucose homeostasis in diabetic patients, have found application in preventing and treating hypertension, cardiovascular disease, and kidney injury [13,58,59,60]. In addition to producing hypoglycemic effects, numerous plants have been demonstrated to be effective against the wide range of diabetic complications (Table 1).…”

Section: Insulin Resistance Reductionmentioning

confidence: 99%

Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review

et al. 2018

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Studies on the antidiabetic mechanisms of medicinal plants have shown that most of them produce hypoglycemic activity by stimulating insulin secretion, augmenting peroxisome proliferator-activated receptors (PPARs), inhibiting α-amylase or α-glucosidase, glucagon-like peptide-1 (GLP-1) secretion, advanced glycation end product (AGE) formation, free radical scavenging plus antioxidant activity (against reactive oxygen or nitrogen species (ROS/RNS)), up-regulating or elevating translocation of glucose transporter type 4 (GLUT-4), and preventing development of insulin resistance. Not only are medicinal plants effective in DM, but many of them also possess a variety of effects on other disease states, including the complications of DM. Such plants may be appropriate alternatives or adjuncts to available antidiabetic medications.

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Renal function in patients with diabetic foot infection; does antibiotherapy affect it?

Cited by 12 publications

References 22 publications

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

Variation in Systemic Antibiotic Treatment for Diabetic Foot Osteomyelitis in England and Wales: A Multi-Centre Case Review

Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review

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