Renal handling of amino acid 99mtechnetium chelates

Chattopadhyay, M.; Banerjee, Sumanta

doi:10.1016/0162-0134(88)85015-3

Cited by 13 publications

(7 citation statements)

References 17 publications

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“…It therefore appeared that cysteine itself might form a bis-bidentate chelate structurally comparable to 99m Tc− l , l -EC and should be recognized by renal tubular transport protein in the same way. However, the 99m Tc complex made from cysteine earlier in this laboratory, though exhibiting high renal specificity in animals, failed to exhibit transportation by the above transport protein . Such results are not surprising since earlier experiments on chelation of cysteine with 99 Tc established that appreciable amounts of polymeric products are formed, − presumably due to the presence of excess thiolate ligand …”

Section: Introductionmentioning

confidence: 86%

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

et al. 1998

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Earlier attempts to obtain technetium complexes with cysteine always resulted in the formation of a product contaminated with polymeric species. A pure product, which could be chemically characterized and adopted for radiopharmaceutical preparation, has now been obtained by using cystine as the precursor of cysteine. This method has been extended to prepare the corresponding rhenium chelate, isolated as the tetraphenylphosphonium salt [Ph(4)P](+)[{ReO(Cys)(2)}(-){HReO(Cys)(2)}].4H(2)O. The X-ray crystal structure of this compound revealed the presence of both neutral and anionic chelated species. In [HReO(Cys)(2)], the cysteine carboxylate moiety is unidentatedly bound to rhenium, while the carboxylic acid of the second cysteine remains as free COOH. The coordination environment around rhenium in the anionic species [ ReO(Cys)(2)(-)] is similar, the only difference being that the uncoordinated carboxylate moiety is present as a COO(-) anion. The thiolate, amine coordination of the ligand with the metal is present in both the chelate units. The compound crystallized in an orthorhombic system with the space group P2(1)2(1)2(1), and having four formula units in each cell. The crystal data are a = 9.700(2) Å, b = 12.836(3) Å, and c = 36.228(3) Å. The rhenium chelate has been structurally correlated with the technetium chelates through comparable spectroscopic and chromatographic data. The technetium-99m analogue of this rhenium chelate exhibited renal tubular transport and renal retention, which makes this radiopharmaceutical useful for evaluation of the clinical status of renal patients.

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Section: Introductionmentioning

confidence: 86%

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

et al. 1998

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“…This study futher demonstrated not only that the excretion of 99mTc-cysteine and 131I-OIH were depressed, but also that renal excretion significantly decreased in the presence of the above two substances, which are known to inhibit renal tubular transport mechanism. 19 The serum creatinine does not show significant difference after injecting both 99mTc-cysteine and 131I-OIH. Results in this study strongly suggest that 99mTc-cysteine can be used to assess renal function in conditions with no impairment of renal function.…”

Section: Discussionmentioning

confidence: 89%

Comparison of the99mTc-cysteine complex and131I-hippuran in biodistribution

Wang¹

1998

J Radioanal Nucl Chem

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This study compares the biological behavior of the 99mTc-cysteine complex with 131I-hippuran (131I-OIH). The potential role of the 99mTc-cysteine complex as a renal imaging agent has also been evaluated. In addition the biological characteristics, i.e., biodistribution, blood clearance, excretory mechanism and the renal excretion pattern in the presence and absence of the tubular transport inhibitor (2,4-dinitrophenol, probenecid) has been examined. The experimental results reveal that kidneys are the target organ. The blood clearance of these radiopharmaceuticals is rapid, approximately 84% of the injected activity is excreted from the kidneys at 1 hour postinjection. Moreover, the renal inhibitor obviously depresses the excretory rate of the 99mTc-cysteine and 131I-OIH, suggesting that such agents are excreted by renal tubular secretion. Results presented demonstrate that the 99mTc-cysteine is a remarkable renal dynamic imaging agent which is highly promising as a new renal imaging radiopharmaceutical.

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“…10 Tc-99m MAG3 kits have been purchased from Mallinckrodt Medical BV, Petten, Holland and have been prepared by a standard method reported in the literature. [7][8][9] Subjects All subjects, volunteers, and patients gave informed consent and were selected from amongst kidney donors (normal volunteers) and patients referred for radionuclide evaluation of renal function. Eleven subjects with normal renal function (determined by intravenous pyelogram, ultrasound blood chemistry, and DTPA study) consisted of the group representing normal volunteers (10 men and 1 woman aged 20 -46 years).…”

Section: Radiopharmaceutical Preparationmentioning

confidence: 99%

“…6 This has prompted a continuing search for another improved Tc-99m-labeled renal imaging agent such as Tc-99m cystine for evaluation of renal function as well as morphology. [7][8] After establishing the efficacy of Tc-99m cystine as a renal agent, 7-10 we have undertaken the clinical evaluation of Tc-99m cystine with Tc-99m MAG3.…”

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confidence: 99%

Comparative Evaluation of Tc-99m Cystine and Tc-99m MAG3 in Normals and Patients With Renal Functional Impairment

Misra

Pradhan²,

Kyle³

et al. 2009

Clinical Nuclear Medicine

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Tc-99m cystine has been proved to be a good renal agent in animals for morphologic as well as the functional status of the kidney. In this study, we compared Tc-99m cystine with Tc-99m mercaptoacetyltriglycine, which is used for evaluation of renal function in normal patients, and those with various degrees of renal functional impairment. The clearance values and static images are compared with Tc-99m mercaptoacetyltriglycine. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.

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Renal handling of amino acid 99mtechnetium chelates

Cited by 13 publications

References 17 publications

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

Oxorhenium(V) and Oxotechnetium(V) Complexes of Cysteine

Comparison of the99mTc-cysteine complex and131I-hippuran in biodistribution

Comparative Evaluation of Tc-99m Cystine and Tc-99m MAG3 in Normals and Patients With Renal Functional Impairment

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