2016
DOI: 10.1681/asn.2015030234
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Renal Hemodynamics in AKI

Abstract: Novel therapeutic interventions are required to prevent or treat AKI. To expedite progress in this regard, a consensus conference held by the Acute Dialysis Quality Initiative was convened in April of 2014 to develop recommendations for research priorities and future directions. Here, we highlight the concepts related to renal hemodynamics in AKI that are likely to reveal new treatment targets on investigation. Overall, we must better understand the interactions between systemic, total renal, and glomerular he… Show more

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Cited by 89 publications
(65 citation statements)
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“…Renal haemodynamics, including macrovascular and microvascular blood flow, are responsible for the correct supply of nutrients and oxygen and therefore are essential to regeneration. Promising haemodynamic‐based therapeutic pathways to treat AKI were recently identified, namely targeting global renal blood flow, glomerular haemodynamics, peritubular microcirculation or vascular integrity . Metabolic reprogramming has emerged as another potential player in septic AKI .…”
Section: Other Important Playersmentioning
confidence: 99%
See 1 more Smart Citation
“…Renal haemodynamics, including macrovascular and microvascular blood flow, are responsible for the correct supply of nutrients and oxygen and therefore are essential to regeneration. Promising haemodynamic‐based therapeutic pathways to treat AKI were recently identified, namely targeting global renal blood flow, glomerular haemodynamics, peritubular microcirculation or vascular integrity . Metabolic reprogramming has emerged as another potential player in septic AKI .…”
Section: Other Important Playersmentioning
confidence: 99%
“…Promising haemodynamic-based therapeutic pathways to treat AKI were recently identified, namely targeting global renal blood flow, glomerular haemodynamics, peritubular microcirculation or vascular integrity. 98 Metabolic reprogramming has emerged as another potential player in septic AKI. 99 It consists of the ability of the host to reprogram metabolic signalling pathways, increasing both its immunologic resistance to microbial burden and its tolerance to inflammation-induced tissue damage.…”
Section: Other Important Playersmentioning
confidence: 99%
“…It was elemental in elucidating the pathophysiology of ischemic and nephrotoxic AKI in the past, but limited information in sepsis-AKI is available. Recent publication by the Acute Dialysis Quality Initiative (ADQI) workgroup [8] has urged that a better understanding of the interactions between systemic, total renal, and glomerular hemodynamics, including the role of tubuloglomerular feedback (TGF) in AKI is needed. Better imaging techniques that would allow direct visualization of renal macro and microvasculature and tissue oxygenation are needed to provide new insights into AKI.…”
Section: Renal Oxygenation and Hemodynamicsmentioning
confidence: 99%
“…Elucidating the efficacy of renoprotective strategies is essential en route to novel treatment options and effective prophylactic regimens for acute kidney injury (AKI) and chronic kidney diseases (CKD) . Current AKI and CKD therapies and prevention strategies are largely experience driven . Today's options for targeted and stratified measures are disappointingly sparse .…”
Section: Introductionmentioning
confidence: 99%