Renal insufficiency induced by cisplatin in rats is ameliorated by cyclosporin A

Campbell, Philip I.; Al-Nasser, I. A.

doi:10.1016/s0300-483x(96)03411-7

Cited by 17 publications

(6 citation statements)

References 16 publications

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“…The increase in serum creatinine and urea levels in the rats after the intraperitoneal administration of cisplatin (group II) shows that cisplatin induced mild kidney dysfunction which is in accordance with previous studies 19 . This damage to the kidney was further experienced with the depletion in the levels of GSH and catalase in the kidney.…”

Section: Discussionsupporting

confidence: 91%

“…The calyces of Hibiscus sabdariffa are rich in vitamin C, hence the reduction in the liver and kidney damages may be ascribed partly to this natural antioxidant which also functions in the conversion of α-tocopheroxy radical to αtocopherol 23 . The extract may also reduce the involvement of Ca 2+ dependent permeabilisation of renal cortex mitochondria as it has been shown that there is a possible involvement of Ca 2+ dependent permeabilisation of renal cortex mitochondria in cisplatin nephrotoxicity 19 . Anthocyanins are ubiquitous in the calyces of the plant thus this property of the extract may be attributed partly to these flavonoids which are known to be potent antioxidants and free radical scavengers 25 .…”

Section: Discussionmentioning

confidence: 99%

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The effect of <i>Hibiscus sabdarriffa</i> calyx extraction cisplatin-induced tissue damage in rats

Okoko¹,

Oruambo²

2009

International Journal of Natural and Applied Sciences

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The effect of Hibiscus sabdariffa calyx extract on cisplatin-induced tissue damage was studied. A total of twenty rats were used for the study and split into four groups of five rats per group-group I, II, III, and IV. Tissue damage was induced in rats of groups II, III, and IV by a single intraperitoneal administration of cisplatin (5 mg/kg b.w.). Four days later, rats in groups III and IV were given 200 mg/kg b.w. and 300 mg/kg b.w respectively of the Hibiscus sabdariffa calyx extract once daily for another five days. Rats in group I were untreated controls. Tissue damage was later assessed in sera by measuring the levels of alanine aminotransferase, aspartate aminotransferase, urea, and creatinine. Thiobarbituric acid reactive species, catalase, and reduced glutathione levels were also measured in the livers and kidneys. The results reveal that the administration of cisplatin alone resulted to a significant increase in the levels of the serum markers over controls (p < 0.05). Cisplatin also caused a significant decrease in catalase activity, and also caused a significant reduction in the levels of reduced glutathione in the liver and kidney over controls (p < 0.05). Cisplatin also caused a significant increase in the levels of thiobarbituric acid reactive species in the liver (p < 0.05). All the markers assessed were brought to near control levels when the Hibiscus sabdariffa extract was given to the rats with the dose of 300 mg/kg b.w. possessing a higher activity. The results show that the Hibiscus sabdariffa extract ameliorated cisplatin-induced tissue damage in rats which may be dose-dependent.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The effect of <i>Hibiscus sabdarriffa</i> calyx extraction cisplatin-induced tissue damage in rats

Okoko¹,

Oruambo²

2009

International Journal of Natural and Applied Sciences

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“…In addition, calyces of Hibiscus sabdariffa contain potent antioxidant components including vitamin C and tocopherol. This explains the protective effect of this plant as it functions in the conversion of α -tocopheroxy radical to α -tocopherol or reduction of Ca +2 dependent permeabilization of renal cortex mitochondria [27–29]. On the other hand, antioxidant and radical scavenger of these calyces are related to the presence of flavonoids known as anthocyanins [27, 30, 31].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Potential Nephroprotective and Antimicrobial Effect ofCamellia sinensisLeaves versusHibiscus sabdariffa(In VivoandIn VitroStudies)

Ibrahim

Al-Badani

2014

Advances in Pharmacological Sciences

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Green tea and hibiscus are widely consumed as traditional beverages in Yemen and some regional countries. They are relatively cheap and the belief is that they improve health state and cure many diseases. The aim of this study was to evaluate the potential protective and antibacterial activity of these two famous plants in vitro through measuring their antibacterial activity and in vivo through measuring nonenzymatic kidney markers dysfunction after induction of nephrotoxicity by gentamicin. Gram positive bacteria like MRSA (methicillin resistant Staphylococcus aureus) were isolated from hospitalized patients' different sources (pus and wound) and Gram negative bacteria including E. coli and P. aeruginosa were used in vitro study. In addition, the efficacy of these plants was assessed in vivo through measuring nonenzymatic kidney markers including S. creatinine and S. urea. Green tea was shown antimicrobial activity against MRSA with inhibition zone 19.67 ± 0.33 mm and MIC 1.25 ± 0.00 mg/mL compared with standard reference (vancomycin) 18.00 ± 0.00 mg/mL. Hibiscus did not exhibit a similar effect. Both Hibiscus- and green tea-treated groups had nephroprotective effects as they reduced the elevation in nonenzymatic kidney markers. We conclude that green tea has dual effects: antimicrobial and nephroprotective.

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“…Mitochondrial dysfunction is a common consequence of ischemia-reperfusion, drug, and toxicant-induced renal injury (Campbell and al-Nasser, 1996;Feldkamp et al, 2005;Honda et al, 2005). It is interesting to note that oxidantinduced mitochondrial dysfunction recovers spontaneously in primary cultures of renal proximal tubular cells (RPTC) in culture, demonstrating the presence of an endogenous mechanism to promote the recovery of mitochondrial function (Nowak et al, 1998;Rasbach and Schnellmann, 2007b).…”

mentioning

confidence: 99%

5-Hydroxytryptamine Receptor Stimulation of Mitochondrial Biogenesis

Rasbach

Funk²,

Jayavelu³

et al. 2009

J Pharmacol Exp Ther

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Mitochondrial dysfunction is both a cause and target of reactive oxygen species during ischemia-reperfusion, drug, and toxicant injury. After injury, renal proximal tubular cells (RPTC) recover mitochondrial function by increasing the expression of the master regulator of mitochondrial biogenesis, peroxisomeproliferator-activated-receptor-␥-coactivator-1␣ (PGC-1␣). The goal of this study was to determine whether 5-hydroxytryptamine (5-HT) receptor agonists increase mitochondrial biogenesis and accelerate the recovery of mitochondrial function. -193). In addition, DOI accelerated the recovery of mitochondrial function after oxidant-induced injury in RPTC. This is the first report to demonstrate 5-HT receptor-mediated mitochondrial biogenesis, and we suggest that 5-HT-agonists may be effective in the treatment of mitochondrial and cell injury.

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Renal insufficiency induced by cisplatin in rats is ameliorated by cyclosporin A

Cited by 17 publications

References 16 publications

The effect of <i>Hibiscus sabdarriffa</i> calyx extraction cisplatin-induced tissue damage in rats

The effect of <i>Hibiscus sabdarriffa</i> calyx extraction cisplatin-induced tissue damage in rats

Evaluation of the Potential Nephroprotective and Antimicrobial Effect ofCamellia sinensisLeaves versusHibiscus sabdariffa(In VivoandIn VitroStudies)

5-Hydroxytryptamine Receptor Stimulation of Mitochondrial Biogenesis

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