2004
DOI: 10.4190/jjvc2001.27.1
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Renal Malformation in the Calves with Weak Calf Syndrome

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“…Calves with abnormal development caused by Claudin-16 (CL-16) deficiency, which is known to cause hereditary renal failure [7, 12-15, 18, 19, 28, 29], non-CL-16 deficiency nephritis, which genotyping is not CL-16 deficiency in spite of similarity to CL-16 deficiency in its clinical symptoms, hematological aspects, and pathological findings [21,22], renal dysplasia, which is suspected to be a hereditary disease [23], neonatal weak calf syndrome [15], hypogenesis syndrome, and other defects are frequently seen in Japanese Black cattle. It has been suggested that neonatal weak calf syndrome is associated with asiderotic anemia and immunodeficiency [16], and that hypogenesis syndrome is associated with growth hormone (GH) deficiency [17], insulin like growth factor-1 (IGF-1) deficiency in contrast with hypersecretion of GH [5,6,11,26], primary or secondary underactive thyroid function [5,6,24,30] and other factors.…”
mentioning
confidence: 99%
“…Calves with abnormal development caused by Claudin-16 (CL-16) deficiency, which is known to cause hereditary renal failure [7, 12-15, 18, 19, 28, 29], non-CL-16 deficiency nephritis, which genotyping is not CL-16 deficiency in spite of similarity to CL-16 deficiency in its clinical symptoms, hematological aspects, and pathological findings [21,22], renal dysplasia, which is suspected to be a hereditary disease [23], neonatal weak calf syndrome [15], hypogenesis syndrome, and other defects are frequently seen in Japanese Black cattle. It has been suggested that neonatal weak calf syndrome is associated with asiderotic anemia and immunodeficiency [16], and that hypogenesis syndrome is associated with growth hormone (GH) deficiency [17], insulin like growth factor-1 (IGF-1) deficiency in contrast with hypersecretion of GH [5,6,11,26], primary or secondary underactive thyroid function [5,6,24,30] and other factors.…”
mentioning
confidence: 99%