Renal manifestations of sarcoidosis: from accurate diagnosis to specific treatment

Correia, Filipe A Saliba C; Marchini, Giovanni Scala; Torricelli, Fábio César Miranda; Danilovic, Alexandre; Vicentini, Fábio Carvalho; Srougi, Miguel; Nahas, William C.; Mazzucchi, Eduardo

doi:10.1590/s1677-5538.ibju.2019.0042

Cited by 36 publications

(18 citation statements)

References 28 publications

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“…Hypercalcemia in sarcoidosis is secondary to an uncontrolled synthesis of 1,25-dihydroxy vitamin D3 by macrophages present in granulomas. The increased 1,25 dihydroxyvitamin D3 leads to increased intestinal absorption of calcium that leads to increased resorption of calcium in the bone ( 139 , 140 ). The most common manifestation of abnormal calcium metabolism is hypercalciuria which is prevalent in ~40–62% ( 119 ).…”

Section: Abnormal Calcium Metabolismmentioning

confidence: 99%

Sarcoidosis: Pitfalls and Challenging Mimickers

Narula

Iannuzzi

2021

Front. Med.

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Sarcoidosis, a systemic granulomatous disease of unknown etiology, may mimic other conditions at presentation often resulting in delayed diagnosis. These conditions include infections, neoplasms, autoimmune, cardiovascular, and drug-induced diseases. This review highlights the most common sarcoidosis mimics that often lead to pitfalls in diagnosis and delay in appropriate treatment. Prior to invasive testing and initiating immunosuppressants (commonly corticosteroids), it is important to exclude sarcoid mimickers.

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Section: Abnormal Calcium Metabolismmentioning

confidence: 99%

Sarcoidosis: Pitfalls and Challenging Mimickers

Narula

Iannuzzi

2021

Front. Med.

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“…Hypercalcemia indicating a possible kidney involvement ( 26 ) or infrequently bone marrow sarcoidosis ( 27 ), was present in 6% of the tested patients. However, none of the patients in our cohort suffered from renal or bone marrow sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical and laboratory characteristics of patients with cutaneous sarcoidosis: A single-center retrospective cohort study

et al. 2022

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BackgroundCutaneous sarcoidosis is a relatively rare disease whose clinical manifestations include red-brown macules, plaques, papules and subcutaneous nodules. The skin changes may also be restricted to pre-existing scars. Cutaneous sarcoidosis can be associated with systemic organ involvement.ObjectivesAim of this retrospective study was to longitudinally investigate clinical and laboratory findings in patients with cutaneous sarcoidosis.MethodsPatients (>18 years) with histologically confirmed cutaneous sarcoidosis between January 2014 and December 2020 were included. Patient demographics, clinical features, laboratory and radiological findings, management, clinical outcomes and co-morbidities associated with cutaneous sarcoidosis were analyzed.ResultsThirty-seven patients with cutaneous sarcoidosis were identified, of whom 57% were female. The most common clinical phenotype of cutaneous sarcoidosis was papular sarcoidosis (n = 16), while plaques and nodules were present in 9 patients. In contrast, subcutaneous (n = 1) and scar-associated sarcoidosis (n = 1) were rare. Of patients with systemic disease, the cutaneous disease followed, preceded, and coincided with the development of systemic sarcoidosis in 2, 9, and 12 patients, respectively. Levels of soluble interleukin (IL)-2 receptor, angiotensin converting enzyme (ACE), and C-reactive protein (CRP) were elevated, in 76%, 21%, and 50% of the tested patients respectively and predicted systemic involvement. Hypercalcemia was present in 6% of patients. Female sex and younger age (<54 years) were significantly associated with systemic manifestations.ConlcusionsCutaneous sarcoidosis was frequently associated with additional systemic involvement, particularly when present in young females. 24 % of patients with cutaneous sarcoidosis developed additional organ involvement during follow-up.

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“…Uno de los principales diagnósticos diferenciales en el presente caso clínico, sería la sarcoidosis con compromiso renal. En esta entidad se describe que la lesión renal clásica es nefritis intersticial granulomatosa no caseificante, asociada a hipercalciuria, hipercalcemia, nefrocalcinosis y nefrolitiasis, con compromiso frecuente de otros órganos como pulmón y piel (7). En la paciente descrita se solicitó tomografía pulmonar de alta resolución, y en ella no se demostró lesiones sugestivas de sarcoidosis.…”

Section: Discussionunclassified