Renal metastasis from papillary carcinoma thyroid detected by whole body iodine scan: A case report and review of the literature

Nair, Lekha; Anila, KR; Sreekumar, A; Pradeep, V. M.

doi:10.4103/0972-3919.183618

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…The prevalence in clinical series is lower and varies between 0.47%87 and 5.3% 6. Multiple case reports have been published in the literature26,88–99 and in general, metastatic renal tumors from thyroid primaries are multiple, bilateral, and usually accompanied by metastatic disease to other sites 85…”

Section: Primary Tumor Sitesmentioning

confidence: 99%

“…The prevalence in clinical series is lower and varies between 0.47% 87 and 5.3%. 6 Multiple case reports have been published in the literature 26,[88][89][90][91][92][93][94][95][96][97][98][99] and in general, metastatic renal tumors from thyroid primaries are multiple, bilateral, and usually accompanied by metastatic disease to other sites. 85 Breast Breast carcinoma represents another potential source for renal metastases, with a prevalence estimated between 4% and 14%.…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

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Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Saeed

Osunkoya²

2022

Advances in Anatomic Pathology

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Metastases to the kidney are rare and were historically described in autopsy series, and the incidence ranged between 2.36% and 12.6%. However, in the contemporary literature with the improvements in imaging modalities (computed tomography scan and magnetic resonance imaging) and other health care screening services, metastatic tumors to the kidney are being diagnosed more frequently in surgical specimens. The utility of needle core biopsies in the primary evaluation of renal masses has also increased the number of sampled metastases, and as a result, only limited histologic material is available for evaluation in some cases and may potentially lead to diagnostic pitfalls. In the last decade, a few large clinical series have been published. In these series, the majority of metastatic tumors to the kidney are carcinomas, with the lung being the most common primary site. A significant number of the various tumor types with metastasis to the kidney are also associated with widespread metastases to other organs, and the renal metastasis may present several years after diagnosis of the primary tumor. The majority of secondary tumors of the kidney are asymptomatic, incidentally discovered, and solitary. There should be a high index of suspicion of metastasis to the kidney in patients with an associated enlarging renal lesion with minimal to no enhancement on imaging and tumor progression of a known high-grade nonrenal malignancy. Secondary tumors of the kidney can be accurately diagnosed by correlating histopathologic features with clinical and radiographic findings and the judicious use of ancillary studies.

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Section: Primary Tumor Sitesmentioning

confidence: 99%

Section: Gastrointestinal Tractmentioning

confidence: 99%

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Saeed

Osunkoya²

2022

Advances in Anatomic Pathology

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“…The particular design of [ 89 Zr]Zr-DFO-Gal3-F(ab') 2 , a protein formed of two F(ab') fragments, results in faster blood clearance and lower liver uptake than traditional mAb-based tracers [125]. The high uptake of [ 89 Zr]Zr-DFO-Gal3-F(ab') 2 in kidneys is due to the urinary excretion [125], which should not be problematic because metastatic TC to the kidney is very rare [126]. For a diagnostic purpose, the dose is usually quite low and so is the nephrotoxicity.…”

Section: Lectin Galactoside-binding Soluble 3 (Lgals3 Galectin-3 or Gal3)-targeting Probesmentioning

confidence: 99%

Next-Generation Molecular Imaging of Thyroid Cancer

Jin

Liu

Younis

et al. 2021

Cancers

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An essential aspect of thyroid cancer (TC) management is personalized and precision medicine. Functional imaging of TC with radioiodine and [18F]FDG has been frequently used in disease evaluation for several decades now. Recently, advances in molecular imaging have led to the development of novel tracers based on aptamer, peptide, antibody, nanobody, antibody fragment, and nanoparticle platforms. The emerging targets—including HER2, CD54, SHP2, CD33, and more—are promising targets for clinical translation soon. The significance of these tracers may be realized by outlining the way they support the management of TC. The provided examples focus on where preclinical investigations can be translated. Furthermore, advances in the molecular imaging of TC may inspire the development of novel therapeutic or theranostic tracers. In this review, we summarize TC-targeting probes which include transporter-based and immuno-based imaging moieties. We summarize the most recent evidence in this field and outline how these emerging strategies may potentially optimize clinical practice.

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“…Although DTC metastases to kidneys are very rare, some cases were indeed reported. On autopsy, 2.5 to 2.7% of all metastases to the kidney originated from thyroid carcinoma [12]. Some of them may be seen on WBS as a result of NIS expression [13].…”

Section: Opis Przypadkumentioning

confidence: 99%

False-positive radioiodine whole-body scan due to a renal cyst

Maciejewski

Czepczyński

Ruchała

2018

Endokrynologia Polska

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Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. A post-therapy whole-body scan allows detection of thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of a 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. On post-therapy wholebody scan, abnormal uptake in the left upper abdomen was found, although stimulated thyroglobulin level was not suggestive for distant metastases of differentiated thyroid carcinoma. Additional SPECT/CT acquisition revealed focal 131 I uptake located at the posterolateral wall of the left kidney corresponding to a round lesion 47 mm in maximal diameter. In order to verify this finding abdominal ultrasound and abdominal contrast-enhanced CT were performed, confirming multiple renal cysts in the left kidney; the largest one was the site of abnormal radioiodine accumulation. Despite the high incidence of renal cysts, especially in the elderly, radioiodine uptake in renal cysts is extremely rare. Different hypotheses on the mechanism of radioiodine uptake in the cyst were proposed, among them active secretion by sodium-iodide symporter or other transporting proteins. We conclude that abnormal radioiodine uptake in renal cysts can be an exceptional finding mimicking a metastasis.

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Renal metastasis from papillary carcinoma thyroid detected by whole body iodine scan: A case report and review of the literature

Abstract: Papillary carcinoma is the most common thyroid malignancy. Usual sites of metastasis include lungs and bone, but renal metastasis is very rare. Here we present a case of a follicular variant of papillary carcinoma with renal and lung metastasis at presentation.

Cited by 4 publications

References 11 publications

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Next-Generation Molecular Imaging of Thyroid Cancer

False-positive radioiodine whole-body scan due to a renal cyst

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