Renal osteodystrophy in children undergoing continuous ambulatory peritoneal dialysis

Hewitt, Ian K.; Stefanidis, Constantinos J.; Reilly, Bernard J.; Kooh, Sang Whay; Balfe, J. Williamson

doi:10.1016/s0022-3476(83)80466-1

Cited by 24 publications

(5 citation statements)

References 24 publications

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“…This was an encouraging observation, since conventional radiographs have shown deteriora tion of previously existent or emergence of new bone lesions in some children on CAPD [31]. It is interesting that remineralization took place despite peritoneal losses of vitamin D metabolites as well as modest amounts of calcium.…”

Section: Discussionmentioning

confidence: 81%

Minerals and Bone-Modulating Hormones in Children on Continuous Ambulatory Peritoneal Dialysis

Freundlich

Zilleruelo

Abitbol

et al. 1985

Nephron

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Peritoneal fluxes of minerals and bone-modulating hormones and their impact on corresponding serum levels and bone mineralization in 7 children on continuous ambulatory peritoneal dialysis (CAPD) were studied. Most mass transfer studies revealed modest losses of calcium into peritoneal effluents. Peritoneal losses of phosphorus and magnesium, although substantial, were not sufficient to normalize hyperphosphatemia and hypermagnesemia in most patients. Parathormone and vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) were readily detectable in peritoneal effluents. Improved bone mineral content, by sequential densitometries, was associated with amelioration of hyperparathyroidism. These data suggest that CAPD in children induces an overall improvement of disturbed mineral metabolism; nevertheless, peritoneal losses of calcium and vitamin D metabolites must be considered and replenished appropriately.

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Section: Discussionmentioning

confidence: 81%

Minerals and Bone-Modulating Hormones in Children on Continuous Ambulatory Peritoneal Dialysis

Freundlich

Zilleruelo

Abitbol

et al. 1985

Nephron

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“…Radiographs of hands, wrists, and knees were examined at both the outset and the end of this study. The radiographs were evaluated according to the presence of subperiosteal erosion of the cortices of long bones and phalanges for the diagnosis of ROD, or increased thickness or fraying of the radiolucent zone in the region of the growth plates for the diagnosis of rickets [3]. The bone age was evaluated according to the atlas of Greulich and Pyle [7], and this bone age was determined by the following formula: Percent bone age = Observed bone age/Chronological bone age X 100.…”

Section: Methodsmentioning

confidence: 99%

“…Continuous ambulatory peritoneal dialysis (CAPD) has been reported to be effective in controlling the progression of ROD in adults [2] and in children [3,4]. Paunier et a1 [4], Salusky et a1 [5], and Fine et a1 [6] reported that ROD improved in children on CAPD if the serum total calcium value was raised to 10.5 to 1 1.5 mg/dl by increasing the vitamin D dosage in order to suppress the serum parathyroid hormone secretion.…”

Section: Introductionmentioning

confidence: 99%

Renal Osteodystrophy in Patients on Continuous Ambulatory Peritoneal Dialysis

Hisano

Yamane

Ueda

et al. 1990

Pediatrics International

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Twelve patients on continuous ambulatory peritoneal dialysis (CAPD) were studied in order to evaluate the progression of renal osteodystrophy (ROD). All patients received doses of 0.01 ‐ 0.02 μg/kg of 1 alpha vitamin D3(1α ‐ D3) and 0.1 ‐ 0.15 g/kg of calcium carbonate for 12 ‐ 18 months. Serum total protein, total calcium (Ca), creatinine, inorganic phosphate alkaline phosphatase (ALP), and n‐terminal parathyroid hormone were measured regularly. The radiological bone appearance for ROD or rickets and the height standard deviation score were compared between the outset and the end of this study. An increase of Ca values and a decrease of ALP values correlated with a suppression of hyperparathyroidism, and the hyperphosphatemia was controlled in the majority of our patients throughout this study. Two patients had ROD and rickets at the outset of this study, and all patients but one had neither ROD nor rickets at the end of this study. Growth retardation improved or remained stable in 10 patients. Our results indicate that adequate doses of 1α ‐ D3 and calcium carbonate are effective in the prevention of ROD and rickets in patients on CAPD.

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“…19). insb esondere in dem sekundäre n Hype rpa rath yreo id isrnus (13 ). welc her in Form der O steiti s fibrosa de n hä ufigste n histo logischen Befund bei de r ren alen Os teopa thie de s Kindes dar stellt (17.…”

Section: Disku Ssionunclassified

Die Epiphysenfuge bei Hämodialyse, Peritonealdialyse und nach Nierentransplantation

Fink

Schneider²,

Wilcke³

et al. 2008

Z Orthop Ihre Grenzgeb

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We evaluated growth, maturity of the skeleton and formation of skeletal deformities and epiphysiolysis of the femoral head in 22 children with end-stage renal failure undergoing haemodialysis, CAPD (continuous ambulatory peritoneal dialysis) and after kidney transplantation. We found growth retardation and disturbances of skeletal maturity in 64% of the children and skeletal deformities in 45%. Children undergoing haemodialysis showed a higher rate of retardation in growth and skeletal maturity than those undergoing CAPD and kidney transplantation. A high level of cortisone and frequent rejections after renal transplantation also lead to poorer growth and skeletal maturity. Children suffering from congenital renal dysfunction showed a higher rate of skeletal deformities. During haemodialysis the level of PTH (parathyroid hormone) was significantly higher than during CAPD and after renal transplantation. Epiphysiolysis capitis femoris lenta was found in 3 children, two of which occurred on both sides. These children had a significantly higher average level of PTH than the other 19.

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Renal osteodystrophy in children undergoing continuous ambulatory peritoneal dialysis

Cited by 24 publications

References 24 publications

Minerals and Bone-Modulating Hormones in Children on Continuous Ambulatory Peritoneal Dialysis

Minerals and Bone-Modulating Hormones in Children on Continuous Ambulatory Peritoneal Dialysis

Renal Osteodystrophy in Patients on Continuous Ambulatory Peritoneal Dialysis

Die Epiphysenfuge bei Hämodialyse, Peritonealdialyse und nach Nierentransplantation

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