Renal Papillary Necrosis in Two Domestic Cats and a Tiger

Wolf, Douglas C.; Lenz, Stephen D.; Carlton, William W.

doi:10.1177/030098589102800113

Cited by 16 publications

(16 citation statements)

References 5 publications

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“…4 In addition, RPN has been seen in 2 domestic cats and 1 tiger; 1 cat and the tiger were treated with NSAIDs. 20 In the current study, RPN was seen in leopards, clouded leopards, cougars, and tigers but not in any of the lions, bobcats, Canadian lynx, snow leopards, cheetahs, ocelots, or the jaguar. All 5 cats with RPN that had received NSAIDs in the past 2 months were treated with meloxicam, which was also used in 5 of the 6 NSAID-treated cats that did not develop RPN; the sixth cat (case No.…”

Section: Discussioncontrasting

confidence: 50%

Renal Lesions of Nondomestic Felids

et al. 2010

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To comprehensively evaluate the occurrence of renal lesions in a variety of nondomestic felids, necropsy cases from 1978 to 2008 were reviewed from a municipal zoo and a large cat sanctuary for those in which the kidneys were examined histologically. Seventy exotic felids were identified (25 tigers, 18 lions, 6 cougars, 5 leopards, 3 snow leopards, 3 clouded leopards, 3 Canadian lynx, 2 ocelots, 2 bobcats, 2 cheetahs, 1 jaguar), and their histologic renal lesions were evaluated and compared. The most common lesion was tubulointerstitial nephritis (TIN); 36 of 70 (51%) cats were affected to some degree. Lymphocytic interstitial nephritis was the most common lesion in the tigers (9 of 25, 36%) and was rarely seen in other species. Although the renal pelvis was not available for all cats, 28 of 47 (60%) had some degree of lymphocytic pyelitis. There was no significant association between the presence of pyelitis and that of TIN. Only 1 cat had pyelonephritis. Renal papillary necrosis was present in 13 of 70 (19%) cats and was significantly associated with historical nonsteroidal anti-inflammatory drug treatment (odds ratio, 7.1; 95% confidence interval, 1.9 to 26.8). Only 1 cat (lion) had amyloid accumulation, and it was restricted to the corticomedullary junction. Primary glomerular lesions were absent in all cats. Intraepithelial pigment was identified in many of the cats but was not correlated with severity of TIN. Despite several previous reports describing primary glomerular disease or renal amyloidosis in exotic felids, these lesions were rare to absent in this population.Keywords exotic felid, kidney, leopard, lion, nephritis, Panthera, tiger Chronic kidney disease is the most common disease affecting older domestic cats. 15 The reported prevalence of kidney disease in domestic cats ranges from 1.6 to 31%.2,15 Despite numerous reports of renal disease in exotic felids, 1,3,8,14,16,19 we could find no reports that describe and compare the occurrence of renal lesions across multiple species of exotic felids.Previous reports of renal lesions in exotic felids have focused mainly on renal AA amyloid deposition in association with systemic AA amyloidosis. 14,16,19 Large studies have reported glomerulosclerosis in captive cheetahs 1 and glomerulonephritis in the Iberian lynx (Lynx pardinus).8 Renal papillary necrosis (RPN) has been reported in 3 lions and a tiger, 3 and there is a single case report of pyelonephritis in a Siberian tiger (Panthera tigris altaica). Materials and MethodsNecropsy records from the University of Tennessee's pathology service were searched for submissions of exotic felids from a municipal zoo and a large cat sanctuary from January 1978 through December 2008. All the cats in this study were housed at a municipal zoo or a large cat sanctuary at the time of their death. Most of the animals were similarly housed, in earth-floored enclosures, and fed all-meat diets. The large cat sanctuary serves as a rescue organization, so the prior history of many of these cats is unknown. Cases we...

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Section: Discussioncontrasting

confidence: 50%

Renal Lesions of Nondomestic Felids

et al. 2010

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“…Parton et al [ 25 ] administered carprofen to healthy cats intravenously and reported that the intravenous administration of carprofen did not cause bleeding or ulceration of the gastric mucosa or change the biochemical and hematological parameters. NSAIDs have not been indicated in renal disease in cats unless impaired renal blood flow occurs [ 33 ]. Differently from the study of Parton et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of Surgical Wound Infiltration with Bupivacaine on Postoperative Analgesia in Cats Undergoing Bilateral Mastectomy

Yılmaz

Toydemir

Kırşan

et al. 2014

The Journal of Veterinary Medical Science

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The analgesic effect of wound infiltration with bupivacaine was evaluated in cats undergoing bilateral mastectomy. Twenty-one female cats with mammary gland tumors were anesthetized with propofol and oxygen-isoflurane anesthesia following premedication with atropine. In the trial group (Group I; n=11), 30 ml of saline containing 2 mg/kg of bupivacaine was infiltrated topically into the surgical wound right after removal of the mammary glands, whereas only saline solution was infiltrated in the control group (Group II; n=10). At the same time, carprofen (4 mg/kg) was also administered subcutaneously in both groups. Behavioral signs of pain were monitored during the recovery period after general anesthesia. In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation. According to the owners’ anwers to the questionnaire, a pain score was specified using a “numerical rating scale” for each cat. Although some cats showed mild to moderate pain, the pain score recorded at 4 hr after the operation was significantly lower in Group I (P<0.001). No significant difference was found at 10 hr after the operation between the groups. The incidence of vocalization, aggression and convulsion within 2 hr after the operation was also lower in Group I. In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

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“…There is only one report of FLX toxicity in feline species (Wolf et al 1991) although, as in the dog, FLX should not be given to any patient at potential risk of renal ischaemia (Smithermann 1992). Other contraindications to the use of FLX in the dog have also been reported, namely interactions with gallamine and methoxyflurane (Mathews et al 1990), with halothane and trimethoprim-sulphadiazine (McNeil 1992), with other steroids (Butterworth and Weaver 1992) or other non-steroidal anti-inflammatory drugs (Elwood et al 1992).…”

Section: Discussionmentioning

confidence: 99%

Post operative analgesic actions of flunixin in the cat

Fonda

1996

Journal of Veterinary Anaesthesia

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Renal Papillary Necrosis in Two Domestic Cats and a Tiger

Cited by 16 publications

References 5 publications

Renal Lesions of Nondomestic Felids

Renal Lesions of Nondomestic Felids

Effects of Surgical Wound Infiltration with Bupivacaine on Postoperative Analgesia in Cats Undergoing Bilateral Mastectomy

Post operative analgesic actions of flunixin in the cat

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