Post operative analgesic actions of flunixin in the cat

Fonda, D.

doi:10.1111/j.1467-2995.1996.tb00288.x

Cited by 8 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ketoprofen is a non‐specific cyclooxygenase inhibitor, that is, it inhibits both COX‐1 and COX‐2 (Landoni and others 1995, Landoni and Lees 1996) and should, therefore, be given only in the postoperative period. Flunixin is another NSAID that is a non‐specific cyclooxygenase inhibitor (Lees and others 1987, McKellar and others 1989, Taylor and others 1994) and although it has been shown to be an effective analgesic in the cat (Fonda 1996) it is rarely used because of the risk of renal side effects, and it is not licensed for use in the cat. Carprofen is a NSAID with a mode of action unlikely to involve cyclooxygenase inhibition (McKellar and others 1994, Delatour and others 1996, Taylor and others 1996) and it is therefore safe to use preoperatively.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat

1998

View full text Add to dashboard Cite

Sixty cats which underwent an ovariohysterectomy were randomly allocated into four treatment groups. One group (controls) received no analgesics postoperatively, and the others received either a single dose of buprenorphine (0.006 mg/kg) intramuscularly, or pethidine (5 mg/kg) intramuscularly, or ketoprofen (2 mg/kg) subcutaneously. The analgesia obtained after each treatment was assessed by three measures. There were significant differences between the groups both for the requirement for intervention analgesia (P = 0.0008) and for the overall clinical assessment (P = 0.0003) with ketoprofen requiring least intervention analgesia and having the best overall clinical assessment, followed by buprenorphine then pethidine. The control group required the most intervention analgesia and had the worst overall clinical assessment. Visual analogue scale scoring for pain produced significant differences between the groups from one hour after the operation, with the cats which were given ketoprofen tending to have lower pain scores than the other groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat

1998

View full text Add to dashboard Cite

show abstract

“…Its half life of 1e1.5 h was actually shorter in the cat than in the dog and it may be more suitable for use in cats than dogs. Fonda (1996)reported that intravenous flunixin (1 mg/kg) provided postoperative analgesia as good as pethidine for at least the first 90 min and no toxic effects were seen. Phenylbutazone was used historically for chronic pain management in many cats prior to market authorisation of carprofen, and although there are only anecdotal reports, toxicity was rarely reported.…”

Section: Nsaidsmentioning

confidence: 99%

Pain management in cats—past, present and future. Part 2. Treatment of pain—clinical pharmacology

Robertson

Taylor

2004

Journal of Feline Medicine and Surgery

141

132

View full text Add to dashboard Cite

Opioids have an unjustified reputation for causing mania in cats, but with refinements in dosing they are now used successfully in this species. The mu-opioid agonists are generally considered the best analgesics. Morphine (0.1-0.3 mg/kg) is effective in a clinical setting. Methadone (up to 0.5 mg/kg) has a similar profile to morphine. Pethidine (Demerol, meperidine; 2-5 mg/kg) is a useful analgesic with a faster onset but shorter duration of action than morphine. Oxymorphone and hydromorphone (0.05-0.1 mg/kg) are widely used in the USA. These opioids are more potent (up to 10 times), and longer acting than morphine in cats. Butorphanol (0.1-0.4 mg/kg) is a mu-opioid antagonist that produces its analgesic actions through kappa agonist activity. It rapidly reaches a ceiling effect, is short acting and is a weaker analgesic than pure mu opioids. Buprenorphine (0.01-0.02 mg/kg), a partial mu-agonist, is the most popular opioid used in small animal practice in the UK, other parts of Europe, Australia and South Africa. In clinical studies it has produced better analgesia than several other opioids and appears to be highly suitable for perioperative pain management in cats. NSAIDs are also used in cats for pain management, although cats metabolise these differently from other species. With appropriate dosing, carprofen (1-4 mg/kg) and meloxicam (0.3 mg/kg) have proved highly effective with few side effects. The use of ketoprofen (2 mg/kg), tolfenamic acid (4 mg/kg) and vedaprofen (0.5 mg/kg) has been reported in cats. Other less traditional analgesics such as ketamine, medetomidine and local anaesthetics are also used for clinical pain management. The transmucosal, transdermal and epidural routes offer novel methods for administration of analgesic drugs and have considerable potential for improving techniques in feline pain management.

show abstract

Newer Analgesics

Taylor

1999

Veterinary Clinics of North America: Small Animal Practice

View full text Add to dashboard Cite

Post operative analgesic actions of flunixin in the cat

Cited by 8 publications

References 18 publications

Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat

Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat

Pain management in cats—past, present and future. Part 2. Treatment of pain—clinical pharmacology

Newer Analgesics

Contact Info

Product

Resources

About