Renal Pelvis and Ureter

An Extremely Rare Kidney Tumor: Primary Intraparenchymal Squamous Cell Carcinoma

“…The histologic features of squamos carcinoma are keratotic cellular debris, pearl formation and intercellular bridges. However, if there is a keratinized squamous metaplasia on the adjacent urothelial surface, especially if dysplasia accompanies, these findings support the diagnosis of the tumor as primary renal pelvis SCC (8,9).…”

Primary Squamous Cell Carcinoma of Renal Pelvis Associated With Renal Calculus and Recurrent Pyonephrosis

“…Histologic presentation reveals tumors with extensive squamous differentiation, and the landmarks are pearl formation, intercellular bridges, and keratotic cellular debris and the conspicuous presence of keratinizing squamous metaplasia of the adjacent flattened urothelium, especially if associated with dysplasia, supports a diagnosis of primary SCC of the renal pelvis which is rare. [6,7] Existing literature and previous studies reveal that metastasis is sporadic and is usually a sign of end stage disease with a poor prognosis as Nativ, et al in their study have divided renal SCC in three groups, reported 1 and 2 year survival rates of locally invasive renal SCC 33% and 22% respectively. [8] The current modality of treatment of RSCC is primarily by Nephrectomy, [1,8,9] to rephrase Nephrectomy with or without ureterectomy even in the presence of distant metastasis.…”

“…[1] Women are affected more frequently than men, predominant age group being 50-70 years. [7] It is presumed that long standing renal calculi (usually staghorn calculus) causes inflammation and infection of the foci that leads to development of pyelonephritis inevitably developing squamous metaplasia and leucoplakia. [6] Other factors are exogenous and endogenous chemicals, vitamin A deficiency, schistosomiasis, smoking; [8] chronic analgesic abuse [4] and phenacetin consumption.…”

Primary Intraparenchymal Squamous Cell Carcinoma of the Kidney: A Rare and Unique Entity

“…In the presence of an identifiable urothelial dysplastic element including urothelial CIS (carcinoma in situ), the tumor should be classified as primary urothelial carcinoma with squamous differentiation. However, the conspicuous presence of keratinizing squamous metaplasia of the adjacent flattened urothelium, especially if associated with dysplasia, supports a diagnosis of primary SCC of the renal pelvis which is rare [ 5 , 6 ]. No such dysplastic urothelial component or metaplastic and/or dysplastic squamous lining of urothelium was found in this case.…”