Renal-protective effect of non-depressor dose of cicletanine in streptozotocin diabetic rats

Kohzuki, Masahiro; Xuemin, Wu; Kamimoto, Masahiro; Yoshida, Kazunori; Watanabe, Minro; Hashimoto, Mika; Kanazawa, Masayuki; Saito, Takao; Yasujima, Minoru; Sato, Tokutaro

doi:10.1097/00004872-199917050-00014

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…The degree of sclerosis in each glomerulus was subjectively graded on a scale of 0 to 4 as follows: Grade 0, no change; Grade 1, sclerotic area less than or equal to 1/4 of the glomerulus or the presence of distinct adhesion between the capillary tuft and Bowman's capsule; Grade 2, sclerosis of 1/4 to 1/2 of the total glomerular area; Grade 3, non-global sclerosis of more than 1/2 of the glomerulus; Grade 4, global sclerosis. The index of glomerular sclerosis (IGS) was calculated using the following formula (21)(22)(23):…”

Section: Methodsmentioning

confidence: 99%

Combination Therapy with an Angiotensin-Converting Enzyme (ACE) Inhibitor and a Calcium Antagonist: Beyond the Renoprotective Effects of ACE Inhibitor Monotherapy in a Spontaneous Hypertensive Rat with Renal Ablation.

Kanazawa¹,

Kohzuki²,

Yoshida³

et al. 2002

Hypertens Res

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Section: Methodsmentioning

confidence: 99%

Combination Therapy with an Angiotensin-Converting Enzyme (ACE) Inhibitor and a Calcium Antagonist: Beyond the Renoprotective Effects of ACE Inhibitor Monotherapy in a Spontaneous Hypertensive Rat with Renal Ablation.

Kanazawa¹,

Kohzuki²,

Yoshida³

et al. 2002

Hypertens Res

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Renal-protective effect of nondepressor dose of cicletanine in diabetic rats with hypertension

Kohzuki

Kamimoto

et al. 2000

American Journal of Hypertension

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We assessed the renal and cardiac benefits of cicletanine (CIC), a furopyridine derivative drug with diuretic and antihypertensive properties, in diabetic spontaneously hypertensive rats with renal impairment. Uninephrectomized streptozotocin (STZ)-diabetic spontaneously hypertensive Izmo rats (SHRIzm) (10 weeks old) were randomly assigned to receive vehicle or CIC (100 mg/kg/day, orally), and age-matched, uninephrectomized STZ diabetic Wistar-Kyoto Izmo rats (WKYIzm) were assigned to receive vehicle for up to 12 weeks. Blood pressure increased progressively in diabetic SHRIzm but not in diabetic WKYIzm. Urinary albumin excretion increased significantly in both diabetic SHRIzm and diabetic WKYIzm throughout the experiment. The antihypertensive effect of CIC was not significantly observed in diabetic SHRIzm. However, the subdepressor doses of CIC significantly decreased urinary albumin excretion, serum creatinine, and blood urea nitrogen in diabetic SHRIzm. These results were confirmed by morphological analysis of kidneys in each group of rats. The index of focal glomerular sclerosis (FGS) in diabetic SHRIzm was significantly higher than that in diabetic WKYIzm. The CIC treatment significantly and effectively protected against an increase in the index of FGS in diabetic SHRIzm. Moreover, CIC treatment significantly attenuated the increase in the heart weight to body weight ratio in diabetic SHRIzm. Treatment with CIC did not affect urinary and blood glucose concentrations at this dose. These results suggest that CIC has a renal-protective action, which is not related to improvement of diabetes or improvement of high blood pressure in diabetic rats with hypertension. The action might be due to the reduction of intraglomerular capillary pressure or protection of the renal glomerular vascular endothelial cell injury and mesangial cell injury through stimulation of PGI2 generation or elimination of free radicals, although the mechanism remains to be further investigated.

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Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure

Kohzuki

Kamimoto

et al. 2001

Journal of Hypertension

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Renal-protective effect of non-depressor dose of cicletanine in streptozotocin diabetic rats

Abstract: These results suggest that CIC has a renal-protective action, which is not related to improvement of diabetes or of high blood pressure in this model. The action might be due to the reduction of intraglomerular capillary pressure, although the mechanism remains to be further investigated.

Cited by 4 publications

References 24 publications

Combination Therapy with an Angiotensin-Converting Enzyme (ACE) Inhibitor and a Calcium Antagonist: Beyond the Renoprotective Effects of ACE Inhibitor Monotherapy in a Spontaneous Hypertensive Rat with Renal Ablation.

Combination Therapy with an Angiotensin-Converting Enzyme (ACE) Inhibitor and a Calcium Antagonist: Beyond the Renoprotective Effects of ACE Inhibitor Monotherapy in a Spontaneous Hypertensive Rat with Renal Ablation.

Renal-protective effect of nondepressor dose of cicletanine in diabetic rats with hypertension

Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure

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