Renal response to anaphylaxis in anesthetized rats and isolated perfused rat kidneys: roles of nitric oxide

Mukai, Kiyotaka; Kuda, Yuhichi; Shibamoto, Toshishige; Tanida, Mamoru; Kurata, Yasutaka; Yokoyama, Hitoshi

doi:10.1007/s12576-017-0583-3

Cited by 8 publications

(12 citation statements)

References 36 publications

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“…Excitation of efferent sympathetic nerves causes vasoconstriction in the innervated vascular beds and a consequent reduction in the relevant blood flow. Consistently, in kidney and skeletal muscle, renal and lumbar sympathoexcitation (24,25) was observed in accord with increases in renal and femoral vascular resistance, respectively, along with reductions in renal and femoral blood flow during anaphylactic hypotension (16,25). However, in this study, the antigen-induced increase in ef-GSNA we observed was not associated with an increased gastric vascular resistance, as previously observed in the same rat anaphylaxis model (12): ef-GSNA increased at the early phase (1-10 min after ovalbumin antigen injection), whereas the gastric vascular resistance increased at the late phase, 9 -40 min after antigen injection in the present study ( Fig.…”

Section: Discussionmentioning

confidence: 53%

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Kuda

Tanida

et al. 2019

American Journal of Physiology-Regulatory, Integrative and Comp

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Systemic anaphylaxis is a life-threatening and allergic reaction that affects various organs. We previously reported that, in the stomach, gastric vasoconstriction occurring at the late phase (15–55 min after injection of ovalbumin antigen) was observed in anesthetized rats sensitized with ovalbumin. In addition, anaphylaxis enhances gastric motility and delays emptying. However, the role of extrinsic autonomic nervous system on antigen-induced gastric alterations was not known. Thus, using the same rat anaphylaxis model, we aimed to determine the changes in the efferent and afferent autonomic nerve activities in the stomach during anaphylactic hypotension. The findings showed that injection of ovalbumin antigen caused substantial systemic hypotension in all sensitized rats. The efferent gastric sympathetic nerve activity (ef-GSNA), but not the efferent vagal nerve activity, increased only at the early phase (1–10 min after injection of ovalbumin antigen) and showed baroreceptor reflex, as evidenced by a stimulatory response to sodium nitroprusside-induced hypotension. In general, excitation of ef-GSNA could induce pylorus sphincter contraction and gastric vasoconstriction. In the present study, we found that sympathectomy attenuated the anaphylaxis-induced decrease in gastric flux but not the increase in gastric vascular resistance. Thus, the increase in ef-GSNA may cause anaphylactic pylorus sphincter contraction but not anaphylactic gastric vasoconstriction. On the other hand, the afferent gastric vagal nerve activity, but not the afferent sympathetic nerve activity, increased during the early phase of anaphylactic hypotension. However, vagotomy produced no effects on the anaphylactic gastric dysfunction. In conclusion, the gastric sympathetic nerves partly modulate stomach function during systemic anaphylaxis.

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Section: Discussionmentioning

confidence: 53%

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Kuda

Tanida

et al. 2019

American Journal of Physiology-Regulatory, Integrative and Comp

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“…When the abdomen was opened, the kidneys were revealed. The artery and vein of the left kidney were separated and renal blood flow (RBF) was measured for 30 min using a flow meter equipped with a special probe (T402, America) and blood flow was recorded as a chart [19,20].…”

Section: Methodsmentioning

confidence: 99%

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

et al. 2019

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Background Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats. Methodology Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion. Results NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation. Conclusions The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.

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“…13,14 The rats were anesthetized and a longitudinal cut was created in the abdomen with a blade. After separation of the artery and vein of the left kidney, after stabilization of amount of blood flow, the renal blood flow (RBF) was recorded for 30 min by using flow meter of Power Lab instrument (T402, America) 15,16 and the mean of blood flow was measured for 30 min. The blood sample was taken from the abdominal aorta by syringe of cold heparin.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

2019

J. contemp. med. sci.

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Objective Renal ischemia-reperfusion (I-R) induces acute kidney injury (AKI). In this study, the effect of hydralazine was investigated on the renal injury induced by the I-R in rats. Methods AKI was induced with bilateral obstruction of the renal artery and vein for 20 min following 24 h of reperfusion. Hydralazine (5mg/ kg) was injected intraperitoneally as post-treatment. Results Hydralazine significantly increased the levels of renal clearance of creatinine and renal blood flow, while they were decreased by I-R. Also, hydralazine significantly improved levels of serum electrolytes (sodium and potassium) that were impaired by I-R. The tissue malondialdehyde levels were significantly suppressed by hydralazine. Conclusion According to the results, the post-treatment of hydralazine had a therapeutic effect on renal I-R because of improved ion reabsorption and excretion and increased renal blood flow and glomerular filtration rate and decreased lipid peroxidation. Key words hydralazine, renal ischemia-reperfusion injury, rat This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

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Renal response to anaphylaxis in anesthetized rats and isolated perfused rat kidneys: roles of nitric oxide

Cited by 8 publications

References 36 publications

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

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