2023
DOI: 10.2174/1381612829666221213104945
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Renal Stem Cells, Renal Resistive Index, and Neutrophil Gelatinase Associated Lipocalin Changes After Revascularization in Patients With Renovascular Hypertension and Ischemic Nephropathy

Abstract: Background: Percutaneous transluminal renal angioplasty (PTRA) with or without stenting is the gold standard therapy in patients with atherosclerotic renal artery stenosis (aRAS). However, therapeutic success depends on the correct timing of revascularization and the reversibility of the renal damage. Materials and Methods: We report a case series of patients treated with PTRA for renovascular hypertension and ischemic nephropathy. We measured bilateral renal resistive index (RRI), circulating renal stem cel… Show more

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Cited by 5 publications
(2 citation statements)
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“…In AKI, NGAL is not only a serum/urinary marker of its severity but also a central effector of progressive renal tissue damage [ 45 ]. In renovascular disease, NGAL is predictor of outcome after revascularization especially in patients with increased RRI [ 46 ]. In our study, we did not find any difference in FGF-23, Klotho and NGAL serum levels between SSc patients with increased RRI compared to SSc patients with normal RRI.…”
Section: Discussionmentioning
confidence: 99%
“…In AKI, NGAL is not only a serum/urinary marker of its severity but also a central effector of progressive renal tissue damage [ 45 ]. In renovascular disease, NGAL is predictor of outcome after revascularization especially in patients with increased RRI [ 46 ]. In our study, we did not find any difference in FGF-23, Klotho and NGAL serum levels between SSc patients with increased RRI compared to SSc patients with normal RRI.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, the elevated risk of unfavorable renal outcomes after revascularization probably starts with even lower RI values. Based on the case series, Cianci et al suggested that RI > 0.75 at baseline and the absence of NGAL reduction after percutaneous renal artery angioplasty were associated with worsening renal function [ 31 ]. By showing an independent negative association of renal RI with kidney perfusion, we support a clear explanation for declining renal function in elevated RI circumstances.…”
Section: Discussionmentioning
confidence: 99%