Renal toxicity induced by folic acid is associated with the enhancement of male reproductive toxicity of di(n-butyl)phthalate in rats

Tsutsumi, Tomoko; Ichihara, Toshio; Kawabe, Mayumi; Yoshino, Hiroko; Asamoto, Makoto; Suzuki, Shugo; Shirai, Tomoyuki

doi:10.1016/j.reprotox.2003.08.004

Cited by 16 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PEs have a strong potential for human exposure in the work place and home environment (Tsutsumi et al ., 2004) . Extensive studies on PE-induced male reproductive toxicity have been reported since Shaffer et al .…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Short Term Toxicity of Phthalate Diesters and Monoesters in Sprague-Dawley Male Rats

Kwack¹,

Han²,

Park³

et al. 2010

Toxicological Research

View full text Add to dashboard Cite

This study was carried out to investigate the short term toxicity of nine phthalate diesters including di-2 (ethylhexyl) phthalate (DEHP) , di (n-butyl) phthalate (DBP) , di-n-octyl phthalate (DnOP) , diethyl phthalate (DEP) , butylbenzyl phthalate (BBP) , dimethyl phthalate (DMP) , di-isodecyl phthalate (DIDP) , diundecyl phthalate (DUP) , and di-isononyl phthalate (DINP) and five phthalate monoesters including mono- (2-ethylhexyl) phthalate (MEHP) , monobutyl phthalate (MBuP) , monobenzyl phthalate (MBeP) , monoethyl phthalate (MEP) , monomethyl phthalate (MMP) and phthalic acid (PA) in Sprague-Dawley male rats. Animals were administered 250 mg/kg/day (monoesters and PA) or 500 mg/kg/day (diesters) of phthalate for two weeks. All animals were examined for body and organ weights, blood hematology, serum biochemistry, and urine analysis. The body weight gain was significantly lower in rats treated with BBP, DBP, DINP, MEHP, MBuP, and PA than that of control. Liver weights were significantly increased in the DEHP,DBP, DnOP, DIDP, and MEHP groups as compared to the control group. Testes weights were significantly decreased only in the DEHP-, DnOP-, and DIDP-treated groups as compared to the control. Significant differences in hematological changes were not observed in any treatment groups. Significant increases in blood glucose levels were observed in the DEHP, MEHP, and MBeP groups. Aspartate aminotransferase (AST) levels were significantly increased in the DBP, DUP, DINP, MBuP, and MBeP groups, whereas alanine aminotransferase (ALT) levels were significantly increased only in the DEHP and MEHP groups. Serum ALP levels were significantly higher in phthalate diester (500 mg/kg/day) -treated rats as compared to control. However, the total cholesterol level was significantly reduced in the DEHP- and DIDP-treated groups, whereas serum triglyceride (TG) levels were higher in the DINP-, MEHP-, and MBuP-treated groups. These results suggest that short term toxicity of phthalate monoesters produces adverse effects as similar to phthalate diesters in Sprague-Dawley rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of the Short Term Toxicity of Phthalate Diesters and Monoesters in Sprague-Dawley Male Rats

Kwack¹,

Han²,

Park³

et al. 2010

Toxicological Research

View full text Add to dashboard Cite

show abstract

“…Another study was carried out to evaluate the therapeutic effects of curcumin on the di-nbutylphthalate (DBP)-induced testicular damage in rats [125]. Benzenedicarboxylic acid dibutyl ester, also known as butylphthalate or di-n-butylphthalate (DBP), is extensively used as a plasticizer in cellulose plastics, as a solvent for dye, and for a variety of other products [126]. Curcumin may stop peroxidative alteration in the sperm and the testicular membrane which leads to enhancement of sperm motility and decrease in spermatozoa defects [125].…”

Section: Curcumin and Male Reproductive Systemmentioning

confidence: 99%

A Review of Therapeutic Effects of Curcumin

Noorafshan

Ashkani-Esfahani²

2013

CPD

122

View full text Add to dashboard Cite

There is a growing interest in herbal medicine. Scientific studies have demonstrated the beneficial pharmacological effects of curcumin. Curcumin is a bright yellow spice, derived from the rhizome of Curcuma longa Linn. It has been proven that curcumin is a highly pleiotropic molecule which can be a modulator of intracellular signaling pathways that control cell growth, inflammation, and apoptosis. Curcumin might be a potential candidate for the prevention and/or treatment of some diseases due to its anti-oxidant, antiinflammatory activities and an excellent safety profile. We present an updated concise review of currently available animal and clinical studies demonstrating the therapeutic effect of curcumin.

show abstract

“…No adverse effects have been reported when high doses of FA (40 -80 mg/day) are administered for as long as 10 years (67). Only one study reported on the use of FA (300 mg/kg, once a week for 4 wk) in rats as a model for interstitial nephritis (86). However, converting this dose from a rat to a human of 75 kg results in a dose of 22.5 g. The main safety concern lies in the fact that folate can mask the diagnosis of pernicious anemia, because high FA levels correct the anemia but allow the neuropathy to progress undiagnosed to an irreversible degeneration of the spinal cord (73).…”

Section: Pharmacological Considerations Of Famentioning

confidence: 99%

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

Moens

Vrints

Claeys

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Folic acid (FA) is a member of the B-vitamin family with cardiovascular roles in homocysteine regulation and endothelial nitric oxide synthase (eNOS) activity. Its interaction with eNOS is thought to be due to the enhancement of tetrahydrobiopterin bioavailability, helping maintain eNOS in its coupled state to favor the generation of nitric oxide rather than oxygen free radicals. FA also plays a role in the prevention of several cardiac and noncardiac malformations, has potent direct antioxidant and antithrombotic effects, and can interfere with the production of the endothelial-derived hyperpolarizing factor. These multiple mechanisms of action have led to studies regarding the therapeutic potential of FA in cardiovascular disease. To date, studies have demonstrated that FA ameliorates endothelial dysfunction and nitrate tolerance and can improve pathological features of atherosclerosis. These effects appear to be homocysteine independent but rather related to their role in eNOS function. Given the growing evidence that nitric oxide synthase uncoupling plays a major role in many cardiovascular disorders, the potential of exogenous FA as an inexpensive and safe oral therapy is intriguing and is stimulating ongoing investigations.

show abstract

Renal toxicity induced by folic acid is associated with the enhancement of male reproductive toxicity of di(n-butyl)phthalate in rats

Cited by 16 publications

References 17 publications

Comparison of the Short Term Toxicity of Phthalate Diesters and Monoesters in Sprague-Dawley Male Rats

Comparison of the Short Term Toxicity of Phthalate Diesters and Monoesters in Sprague-Dawley Male Rats

A Review of Therapeutic Effects of Curcumin

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

Contact Info

Product

Resources

About