Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol

Nakazawa, Tomomi; Kasahara, Ken-ichiro; Ikezaki, Shinichiro; Yamaguchi, Yuko; Edamoto, Hiroshi; Nishimura, Nobuo; Yahata, Megumi; Tamura, Kazutoshi; Kamata, Eiichi; Ema, Makoto; Hasegawa, Ryuichi

doi:10.1293/tox.22.125

Cited by 10 publications

(14 citation statements)

References 23 publications

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“…3). Consistent with the high nuclear density, PCNA immunohistochemistry was strongly positive in the cystic epithelium as compared to the adjacent tubules 8 . However, no polypoid or papillary proliferation was noted, and the hyperplastic lining epithelium remained in a cuboidal to columnar form within a simple monolayer.…”

supporting

confidence: 71%

“…They are associated with a wide spectrum of chemical groups, including pcumylphenol (PCP), a chemical used as lubricants, surfactants, insecticides and phenolic resins 7 . A previous investigation focused on morphologically characterizing cystic kidneys induced in rat neonates when dosed with PCP for 18 days from postnatal day (PND) 4 revealed that treatment with PCP resulted in the sequential formation of cystic tubules in rat neonates 8 . A follow-up investigation was carried out to determine the critical dosing period for PCP to develop cystic kidneys in rat neonates.…”

mentioning

confidence: 99%

“…1). The dose level and dosing schedule of PCP were designed in reference to the results obtained from the previous study where histopathological examinations on PND 8, 12, 19, and 22 revealed that the development of cystic kidneys was confined to PND 19 and thereafter following daily PCP dosing from PND 4 at 300 mg/kg/day 8 . All the animals were housed in an environmentally controlled room and were allowed free access to a sterilized basal diet (CRF-1, Oriental Yeast Co. Ltd., Tokyo, Japan) and tap water.…”

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confidence: 99%

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A possible critical dosing period of p-cumylphenol for development of cystic kidneys in rat neonates

et al. 2022

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In accordance with a previous report on cystic kidneys induced in rat neonates when dosed with p-cumylphenol (PCP) for 18 days from postnatal day (PND) 4, 3 rat neonates were dosed with PCP once a day for 14 days, either from PND 14, 21, 28, 35, or 42 as W2, W3, W4, W5, and W6 groups, respectively, to investigate whether dosing periods in different PNDs influenced the development of cystic renal tubules.The lesion was striking in the W2 group and at a lesser magnitude in the W3 group, whereas either kidney was unaffected when dosing was initiated beyond PND 28. These findings, together with the results from the previous study, suggested that PND 14-28 is a critical dosing period for PCP to develop cystic kidneys in rat neonates. The lining epithelium of the cystic tubules was immunohistochemically positive for AQP2. This finding and the anatomical location indicated that the cystic tubules were of collecting duct origin.Either obstruction, fluid accumulation, or reparative hyperplasia of the lining epithelium was unlikely to be involved in the formation of cystic tubules lined with a monolayer of cuboidal or columnar epithelium with a high nuclear density. Thus, the follow-up investigation on PCP suggested a critical dosing period of PND 14-28 in rat neonates for the development of cystic dilation of renal collecting ducts. This study further supports that additive hyperplasia of the lining epithelium is a fundamental basis of this unique lesion.

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confidence: 71%

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confidence: 99%

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A possible critical dosing period of p-cumylphenol for development of cystic kidneys in rat neonates

et al. 2022

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“…In addition, the 1/2Nx rats showed renal tubular dilatation 84 days later, but there was no evidence of progression of marked fibrosis or glomerular lesions. An increase in the number of PCNA-positive cells has been shown to correlate with renal tubular regeneration and cystic formation [38,39]. Therefore, the increased number of PCNA-positive epithelial cells in DEK-DM is considered to reflect the increased number of renal tubules and the progression of tubular dilation.…”

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confidence: 99%

Characterization of Enlarged Kidneys and Their Potential for Inducing Diabetes in DEK Rats

Domon

Katayama

Yamada

et al. 2021

Biology

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The kidneys participate in the regulation of systemic glucose metabolism via gluconeogenesis, insulin degradation, and the tubular reabsorption of glucose. The present study characterized rats from a strain of a novel type 2 diabetes model with enlarged kidneys (DEK). Histological and biochemical analyses of DEK rats were performed to assess the relationships between their kidneys and hyperglycemia. The kidney weight of diabetic DEK (DEK-DM) gradually increased over time from the onset of diabetes, with the glomerular number being higher in DEK-DM than in normal DEK (DEK-cont). A positive correlation between blood glucose level and kidney weight was observed in DEK-DM. The similar glomerular size and single glomerular creatinine clearance in DEK-cont and DEK-DM indicated that glomerular hypertrophy and hyperfiltration were not involved in the renal enlargement. Uninephrectomy (1/2Nx) in DEK-DM resulted in a reduction in blood glucose level at 7–28 post-operation days, with this concentration remaining lower than in Sham group until 84 days post-operation. 1/2Nx also improved systemic conditions, including reduced body weight gain, polyuria, polydipsia, and hyperphagia. Plasma concentrations of Na, total cholesterol, albumin, and total protein were higher, and urinary excretion of glucose, urea nitrogen, and proteins were lower, in the 1/2Nx than in the Sham group. Remnant kidney weight was two-fold higher in the 1/2Nx than in the Sham group 84 days later. In addition, 1/2Nx resulted in renal tubular dilatation but not in the progression of fibrosis or glomerular lesions. Taken together, these findings indicate that enlarged kidneys were associated with the onset of diabetes and with the resistance to diabetic nephropathy in DEK-DM.

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“…Our study was concord with Tootian et al [15,25] that demonstrated high percent of creatinine, blood urea nitrogen, alkaline phosphatase which consider waste products of protein metabolism that excreted by the kidney and give indicators of kidney destruction. In other study was Conducted on rat reveal that nitrophenol compound cause deformity in the shape of mitochondria with dense deposits in the basement membranes of the glomeruli was noted in electron microscope [15,27,28].…”

Section: Discussionmentioning

confidence: 99%

Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

MJ¹,

Mohamed²,

Ghusoon³

2016

Anat Physiol

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Atonik is a synthetic bio stimulant consist of three phenolic compounds used as stimulant plant growth and development, farmers used atonik with high abuse for enhancements of fruit maturity so study done to detect the harmful effect of atonik in laboratory animal.Eight female rabbits of weighting (1.4-1.6) kg were obtained from animal house in college of Veterinary Medicine, animal housed two weeks before beginning study and all laboratory condition was taking into consideration. Animal randomly divided in to two main groups: Control group still without treatment at all period of study, Atonik group: each rabbits orally received 0.1 mg/kg /three time weekly (TIDW). Our result disturbance of hematological parameters specially WBCS, RBCS, HB and lymphocyte. Moreover histopathological section showing dilation of the central vein and filled with fluid and granuloma beside it, with vaculation of hypatocyte. Kidney reveals coagulative necrosis of renal tubules with distraction of glomerular tuft. Uterus of rabbits treated with 0.1 mg/kg bw atonik for 8 weeks showing necrosis of unrein glands. Ovary showed increase in the numbers of attratic follicles. Our result concluded that atonik has very harmful effect for reproduction, liver, and kidney.

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Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol

Cited by 10 publications

References 23 publications

A possible critical dosing period of p-cumylphenol for development of cystic kidneys in rat neonates

A possible critical dosing period of p-cumylphenol for development of cystic kidneys in rat neonates

Characterization of Enlarged Kidneys and Their Potential for Inducing Diabetes in DEK Rats

Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

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