Renal tubular dysfunction in primary Sjögren's syndrome: Clinical studies in 27 patients

Abstract

Kidney involvement in Sjögren's syndrome (SS) including renal tubular disorders are well recognized but little is known about frequency and extent of such dysfunction in the general population of patients with primary SS, due to a lack of group studies. We studied 27 patients with primary SS and without other possible causes of tubular dysfunction. Increased urinary beta 2M excretion, due to proximal tubular dysfunction, was present in 26% of patients. Inadequate urine acidification after oral NH4 Cl, proving distal tubular dysfunction, was found in 12% of the patients studied. Concentrating ability, tested by thirst, was decreased in 44% of patients studied. Abnormal renal tubular tests correlated with presence of ANA (p = 0.05) but not with other clinical parameters. In conclusion demonstrable renal tubular dysfunctions occur in over half the patients with primary SS. Literature concerning this subject is discussed.

Subclinical renal tubular acidosis in patients with primary and secondary Sjögren's syndrome: a possible marker of disease progression

“…24,25 With respect to the proximal tubular dysfunction, urinary 2 -m excretion is reported to be abnormal in 26% of primary SS patients with a higher prevalence than that of RTA (12%) in a group of patients. 26 Our results also demonstrated that mean 2 -m excretion in the urine was apparently higher in patients with subclinical RTA. Eleven of 17 patients with subclinical RTA showed abnormal excretion.…”

Frequency and predictive value of the clinical manifestations in Sjögren’s syndrome

“…There is also an increased incidence of urinary tract infection in patients with Sjögren's syndrome (16). Renal tubular dysfunction was reported in approximately 50% of patients with SS (17). Other renal involvement includes increased incidence of interstitial nephritis, glomerulonephritis, and ostemalacia as a result of renal tubular dysfunction (18,19).…”

Hypokalemic Quadriparesis in a female-The marker for Sjogren′s syndrome

“…[2][3][4][5][6][7][8][9][10] Hypokalemic paralysis due to type 1 renal tubular acidosis in SS has been reported worldwide. [11][12][13][14][15][16][17][18][19] It may precede the sicca symptoms or it may be the first presentation of SS despite long duration of exocrine gland involvement.…”