Renal tubular sodium and water reabsorption in the isotonic sodium chloride-loaded rat

Landwehr, DM; Klose, RM; Giebisch, Gerhard

doi:10.1152/ajplegacy.1967.212.6.1327

Cited by 96 publications

(49 citation statements)

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“…The mean nephron GFR in the absence of clamping in the moderate infusion group was about 20% higher, presumably reflecting the effect of extracellular fluid (ECF) volume expansion. A higher filtration rate also was seen in the whole kidney, a finding previously noted by others (17,18,13). In the rapid infusion group, the mean nephron GFR was 74 nl/min, a value about 70% higher than that found in rats receiv- t7) (7) (7) (7) (7) (7) (7) (7)…”

Section: CDsupporting

confidence: 63%

The relationship between glomerular filtration rate and sodium reabsorption by the proximal tubule of the rat nephron

Brenner¹,

Bennett²,

Berliner³

1968

J. Clin. Invest.

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We have tested two of the hypotheses proposed to explain the adjustment in sodium reabsorption in the proximal tubule that follows a change in the rate of glomerular filtration (glomerulotubular balance). Using the recollection micropuncture technique, we were able to measure the immediate and late changes in reabsorptive rate after an acute alteration in filtration rate produced by aortic constriction and release of constriction. It was found that fractional reabsorption, as measured by the inulin tubule fluid to plasma (TF/P) ratio, increased after aortic constriction and decreased after release, but that in most instances, absolute reabsorptive rate changed in parallel to glomerular filtration rate. The change was similar whether the collections were made less than 1 or more than 5 min after the change in blood pressure. dence against an intrarenal humoral feedback mechanism.In the same experiments we measured the (TF/P) ,, transit time, and flow rate of fluid in single nephrons before and during aortic constriction or release of aortic constriction. The change in reabsorptive rate and the simultaneous change in calculated cross-sectional area of the tubule lumen were rarely proportional, i.e., C/irr2 was not constant. In other experiments, these same measurements were made before and during periods of increased ureteral pressure. Despite large increments in calculated cross-sectional area, the absolute rate of reabsorption either remained relatively unchanged or fell in proportion to the change in filtration rate. It is concluded that under these conditions, reabsorptive rate is. governed by some factor other than tubule geometry.

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Section: CDsupporting

confidence: 63%

The relationship between glomerular filtration rate and sodium reabsorption by the proximal tubule of the rat nephron

Brenner¹,

Bennett²,

Berliner³

1968

J. Clin. Invest.

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“…Infusions of isotonic saline or Ringer's solution produce a decrease in reabsorption in the proximal tubule with a prolongation of the split-droplet halftime (8,27,28). The present experiments establish that the reabsorptive capacity of the proximal tubule is powerfully influenced by the volume of the extracellular fluid over the entire spectrum of bodily hydration (8).…”

Section: Discussionsupporting

confidence: 63%

Accelerated reabsorption in the proximal tubule produced by volume depletion

Weiner¹,

Weinman²,

Kashgarian³

et al. 1971

J. Clin. Invest.

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A B S T R A C T The renal response to chronic depletion of extracellular volume was examined using the techniques of micropuncture. Depletion of salt and water was produced by administration of furosemide to rats maintained on a sodium-free diet. There was a marked fall in body weight, plasma volume, and glomerular filtration rate. The intrinsic reabsorptive capacity of the proximal tubule, measured by the split-droplet technique, was greatly enhanced. The acceleration of proximal fluid reabsorption could not be accounted for by changes in filtration rate, tubular geometry, or aldosterone secretion. The half-time of droplet reabsorption in the distal tubule was not altered by sodium depletion.An increase in the reabsorption of fluid in the proximal tubule, as demonstrated directly in the present experiments, provides an explanation for a variety of clinical phenomena associated with volume depletion. INTRODUCTIONIt is now well established that expansion of the extracellular fluid leads to renal excretion of salt and water in large part through the mechanism of decreased reabsorption in the proximal tubule. It is also well-known that depletion of extracellular volume regularly induces retention of salt and water, but the mechanism is not so precisely established. There is reason to think that, in addition to a fall in glomerular filtration rate, there is an accelerated reabsorption of sodium in the proximal tubules resulting in decreased delivery of filtrate to the distal nephron. Thus far, however, the evidence has been

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“…Expansion of extracellular fluid volume reduces fractional proximal tubular reabsorption (see e.g. Landwehr, Klose & Giebisch, 1967); this may be responsible for the change occurring in late-pregnant animals, as the reduced haematocrit (Table 1) confirms the reported increase in extracellular fluid volume (Atherton & Pirie, 1981).…”

Section: Discussionmentioning

confidence: 61%

Fluid reabsorption by the proximal convoluted tubule of the kidney in lactating rats.

Arthur¹,

Green²

1986

The Journal of Physiology

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SUMMARY1. Using free-flow micropuncture techniques, the rate of reabsorption from the proximal convoluted tubules was measured in virgin, 19-day-pregnant and 6-to 7-day-lactating Sprague-Dawley rats.2. In separate groups of animals proximal convoluted tubules were filled with silicone rubber, dissected out and their lengths measured.3. Single nephron glomerular rate was increased in pregnant and lactating animals. 4. The rate of reabsorption per unit length of the proximal convoluted tubule was decreased in pregnant animals but similar in virgins and lactating rats.5. The proximal convoluted tubule was increased in length in pregnant and lactating animals. As a result the total reabsorption by the proximal convoluted tubule was similar in virgin and pregnant animals but increased in lactating animals.6. The amount reabsorbed by the loop of Henle and distal parts of the nephron is greater in pregnant and lactating animals than in virgins.

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Renal tubular sodium and water reabsorption in the isotonic sodium chloride-loaded rat

Cited by 96 publications

References 0 publications

The relationship between glomerular filtration rate and sodium reabsorption by the proximal tubule of the rat nephron

The relationship between glomerular filtration rate and sodium reabsorption by the proximal tubule of the rat nephron

Accelerated reabsorption in the proximal tubule produced by volume depletion

Fluid reabsorption by the proximal convoluted tubule of the kidney in lactating rats.

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