In recent years, an increasing interest in geothermal energy has been registered in both the scientific community and industry. The present work aims to analyse the energy performance and the economic viability of an innovative high-efficiency geothermal-driven integrated system for a combined heat and power (CHP) application. The system consists of a heat exchanger (HEX) and a transcritical organic Rankine cycle (ORC) that work in parallel to exploit a high-temperature geothermal source (230 °C) and satisfy the energy demand of a commercial centre located in Southern Italy. The ORC and HEX sub-units can operate at partial load to increase the system flexibility and to properly react to continuous changes in energy request. A lumped model was developed to find the proper operating conditions and to evaluate the energy production on an hourly basis over the whole year. In particular, a multi-variable optimisation was implemented to find the most suitable configuration and a 101.4 kWel ORC was selected while the HEX nominal power was 249.5 kWth. The economic viability of the integrated system was evaluated in terms of net present value and payback period and different operating strategies were compared: thermal-driven, electric-driven, and a mixed strategy. The latter turned out to be the best solution according to both energy and economic criteria, with electric and thermal self-consumptions larger than 90%, with no heat dumping and a payback time close to five years.