Renewal of DNA in non-dividing cells and ageing

Pelc, S. R.

doi:10.1016/0531-5565(65)90005-7

Cited by 17 publications

(1 citation statement)

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“…The age-dependent changes discussed by Pyhtila and Sherman (1969), Tsien and Wattiaux (1971), Pelc(1965), Bozcuk (1972), Orgel (1963Orgel ( ), M edvedev (1972 in protein, DNA, RNA and at the transcriptional level are difficult to correlate with the present results but they imply that non-random variation in information states can be passed from one generation to another through ova or both ova and sperm. Such changes are presumably responses to changes in the internal environment at~d some known examples may be relevant to the present study.…”

Section: Discussioncontrasting

confidence: 54%

The Lansing effect and age-mediated changes in genetic parameters

Beardmore

Shami

1985

Genetica

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The influence of variation in age of grandparents upon the heritability of two metric characters has been studied in the guppy (Poecilia reticulata) and Drosophila melanogaster. In both cases effects on heritability paralleling those already demonstrated to occur with variation in parental age were found and may be regarded as examples of Lansing effects.Analysis of components of variance of sternopleural bristle number in Drosophila suggest that the genotypic variance for this character is increased in the progenies of older parents, largely as a consequence of an increase in additive genetic variance. It appears probable that this results from age mediated changes in mechanisms of gene control.Both the effects described seem likely to be reflections of fundamental aspects of ageing processes in biological systems.

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Section: Discussioncontrasting

confidence: 54%

The Lansing effect and age-mediated changes in genetic parameters

Beardmore

Shami

1985

Genetica

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Regeneration of crushed mammalian skeletal muscle and effects of steroids

Sloper

Pegrum

1967

J. Pathol.

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The biological activity of Odontomyces viscosus, which has been reported to cause periodontal disease in hamsters, was examined. The microorganism was cultured anaerobically in Brain Heart Infusion broth, and the cells were harvested. The washed cells were injected intradermally into the abdomen of rabbits. After 72 hr, a well-defined, firm, raised nodule (about 1.0 by 1.5 cm) with an erythematous border was seen at the injection site. Suspensions of cell wall and cytoplasmic material were injected intradermally, and the lesions appeared only at the site of cell wall injection. The cell walls, which were then treated with trypsin, pepsin, and ribonuclease, again produced the characteristic lesion. These nodular dermal lesions persisted for a minimal time of 10 days. The enzymatically treated cell walls were then hydrolyzed with 1 n HCl, and such hydrolysis up to 1 hr failed to alter the toxic activity of the cell walls. Similar dermal nodular lesions were obtained by injection of enzymatically treated cell walls of strains of Staphylococcus aureus, Streptococcus groups B, C, E, F, K, Lactobacillus casei, and Actinomyces israelii. Treatment with hot and cold trichloroacetic acid solutions and proteolytic enzymes, or with formamide, yielded insoluble fractions which produced the characteristic nodular lesions. The size of the lesion resulting from injection of these fractions was proportional to the amount of the injected material. The active fraction, which does not appear susceptible to hydrolysis by lysozyme, is thought to be cell wall mucopeptide. Histological studies showed skin abscesses due to the toxic reaction; however, in addition to the acute inflammatory reaction, there was local eosinophilia.

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