Renewed selection for heat loss in mice: Direct responses and correlated responses in feed intake, body weight, litter size, and conception rate1

McDonald, J. M.; Nielsen, Marie Vejrup

doi:10.2527/jas.2006-465

Cited by 17 publications

(21 citation statements)

References 18 publications

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“…Selection continued until the 16th generation, and the line was maintained until the 41st generation. McDonald and Nielsen () extended breeding for an additional nine generations, the 42nd to the 51st. They reported that the difference in FI/BW during 8–11 weeks of age between the MH and ML mice was approximately 27% of the MC mean, with the MH mice consuming more feed than the ML mice.…”

Section: Discussionmentioning

confidence: 99%

“…Selection continued until the 16th generation, and the line was maintained until the 41st generation. McDonald and Nielsen (2007) Hong et al (2013) reported that the L line was significantly superior to the H line in FCR at the eighth and ninth generations. Furthermore, Hong et al (2015) confirmed that the FCR of individual feeding of the L-line mice was significantly greater than that of H-line mice at the 11th generation.…”

Section: Discussionmentioning

confidence: 99%

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Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Darhan

Kikusato

Toyomizu

et al. 2016

Animal Science Journal

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Maintenance energy requirements (MER) of mice selected for high (H) or low (L) oxygen consumption (OC) were compared. Forty-four mice from H and L OC lines were weaned at 3 weeks and divided into four experimental groups: group A were sacrificed at 4 weeks; group B were fed ad libitum, and groups C and D were fed 2.8 and 2.4 g/day, respectively, from 4 to 8 weeks of age. Groups B-D were sacrificed at 8 weeks. Chemical components were estimated for all groups. MER was estimated using a model that partitioned metabolizable energy intake into that used for maintenance, and protein and fat deposition. The feed conversion ratio for the B group was significantly higher in the H than in the L line. Feed intake for metabolic energy content per metabolic body size was significantly also higher in the H line, whereas accumulated energy content per metabolic body size was significantly higher in the L line. MER of the H line was greater than that of the L line (P < 0.10). These results suggest that selection for H or L OC produced differences in chemical components, feed efficiency, and MER between the H and L lines.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Darhan

Kikusato

Toyomizu

et al. 2016

Animal Science Journal

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“…We measured OC by mouse as an indirect index of maintenance energy requirement and conducted selection for high and low OC in this study. McDonald and Nielsen (2007) extended breeding for an additional nine generations from the 42nd to the 51st generation. Furthermore, the present study confirmed that the FCR of the individual feeding of L line mice was significantly superior to that in H line mice at the 11th generation.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, lowering the feed cost is an important objective in animal breeding. McDonald and Nielsen (2007) continued to select these lines for an additional nine generations from G42 through G51. Therefore, control of the energy utilized for maintenance influences production efficiency.…”

Section: Introductionmentioning

confidence: 99%

Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice

Ardiyanti

Kikusato

et al. 2015

Animal Science Journal

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Selection for high (H) and low (L) oxygen consumption (OC) as an indirect estimation of maintenance energy requirement was determined. Feed intake and body weight were measured and feed conversion ratio (FCR) of 4-8-week-old mice was calculated. Respiratory activity of hepatic mitochondria was measured at 12 weeks. Total feed intake (H: 103.74 g, L: 97.92 g, P < 0.01), daily feed intake (H: 3.70 g/day, L: 3.50 g/day, P < 0.01) and FCR (H: 18.79, L: 15.50, P < 0.01) were significantly different between lines. The line by sex interaction was significant for FCR. No line differences were observed in males; and the FCR of the H line was greater than in the L line in females. H line mice had the highest hepatic mitochondrial respiratory activity in state 2 (P < 0.01), the highest uncoupled respiratory rate of mitochondria in the presence of an uncoupling agent (P < 0.001), and the mitochondrial proton leak. The adenosine diphosphate/ O ratio was highest in the L line (P < 0.05). This suggests that the selection for high and low OC induced differences in basal mitochondrial respiration and basal metabolism, resulting in difference in FCR between H and L lines.

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“…Further support for the HDL theory comes from comparisons of the reproductive performance of mice selectively bred to enhance their capacity to dissipate heat (Nielsen et al, 1997a;Nielsen et al, 1997b;Kgwatalala et al, 2004;McDonald and Nielsen, 2006). These mice have elevated milk production and raise heavier litters (McDonald and Nielsen, 2007). …”

Section: New Ideas On Limits To Sustained Energy Intakementioning

confidence: 99%

Limits to sustained energy intake. XIII. Recent progress and future perspectives

Speakman

Król

2011

Journal of Experimental Biology

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Summary Several theories have been proposed to explain limits on the maximum rate at which animals can ingest and expend energy. These limits are likely to be intrinsic to the animal, and potentially include the capacity of the alimentary tract to assimilate energy – the ‘central limitation’ hypothesis. Experimental evidence from lactating mice exposed to different ambient temperatures allows us to reject this and similar ideas. Two alternative ideas have been proposed. The ‘peripheral limitation’ hypothesis suggests that the maximal sustained energy intake reflects the summed demands of individual tissues, which have their own intrinsic limitations on capacity. In contrast, the ‘heat dissipation limit’ (HDL) theory suggests that animals are constrained by the maximal capacity to dissipate body heat. Abundant evidence in domesticated livestock supports the HDL theory, but data from smaller mammals are less conclusive. Here, we develop a novel framework showing how the HDL and peripheral limitations are likely to be important in all animals, but to different extents. The HDL theory makes a number of predictions – in particular that there is no fixed limit on sustained energy expenditure as a multiple of basal metabolic rate, but rather that the maximum sustained scope is positively correlated with the capacity to dissipate heat.

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Renewed selection for heat loss in mice: Direct responses and correlated responses in feed intake, body weight, litter size, and conception rate1

Cited by 17 publications

References 18 publications

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Selection for high and low oxygen consumption‐induced differences in maintenance energy requirements of mice

Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice

Limits to sustained energy intake. XIII. Recent progress and future perspectives

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