Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents

Šimonytė, Sandrita; Kučienė, Renata; Medžionienė, Jūratė; Dulskienė, Virginija; Lesauskaitė, Vaiva

doi:10.1186/s12881-017-0462-z

Cited by 24 publications

(19 citation statements)

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“…In multiple binary logistic regression analyses (adjusted for age and BMI) and by categorising sleep duration into four groups (≤8 h, 8.1-8.9 h, 9.0-9.9 h, ≥10 h), shorter sleep duration was also shown to be a risk factor for increased BP. There are several studies examining the relationship between increased BP and various environmental conditions, other than sleep duration ( 22 , 23 , 24 , 25 , 26 ). In this present study, the only other significant environmental risk factor identified was location of the school the children or adolescents were attending and this was only true of the girls.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Blood Pressure and Sleep Duration in Turkish Children: A Cross-Sectional Study

Bal

Öztürk

Çiçek

et al. 2018

Jcrpe

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Objective:As in adults, hypertension is also an important risk factor for cardiovascular disease in children. We aimed to evaluate the effect of sleep duration on blood pressure in normal weight Turkish children aged between 11-17 years.Methods:This cross-sectional study was conducted in the primary and secondary schools of the two central and ten outlying districts of Kayseri, Turkey. Subjects were 2860 children and adolescents (1385 boys, 1475 girls). Systolic and diastolic blood pressures were measured according to the recommendations of the Fourth Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. Sleep duration was classified as follows: ≤8 hours, 8.1-8.9 hours, 9.0-9.9 hours or ≥10 hours.Results:For short sleeper boys and girls (participants with a sleep duration ≤8 h) the prevalence of prehypertension and hypertension was 35.0% and 30.8%, respectively. In univariate binary logistic regression analyses (age-adjusted), each unit increment in sleep duration (hours) in boys and girls, decreased the prehypertension and hypertension risk by 0.89 [odds ratio (OR)] [confidance interval (CI); 0.82-0.98] and 0.88 (OR) (CI; 0.81-0.97), respectively (p<0.05). In multiple binary logistic regression analyses [age- and body mass index (BMI)-adjusted] the location of the school and sleep duration categories were shown to be the most important factors for prehypertension and hypertension in both genders, while household income was the most important factor, only in boys.Conclusions:A sleep duration ≤8 h is an independent risk factor for prehypertension and hypertension in Turkish children aged 11-17 years.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Blood Pressure and Sleep Duration in Turkish Children: A Cross-Sectional Study

Bal

Öztürk

Çiçek

et al. 2018

Jcrpe

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“…We selected two polymorphisms in the AGT gene, i.e., rs699 (M235T in exon 2) and rs5050 (A-20C in the promoter region), for detection. The selection of the two functional polymorphisms was based on a thorough evaluation of polymorphisms associated with vasculopathy [22, 25–27]. Genomic DNA was extracted from all KD cases and controls blood using the TIANamp Blood DNA Kit (Qiagen, Dusseldorf, Germany).…”

Section: Methodsmentioning

confidence: 99%

An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease

Liu

et al. 2019

Disease Markers

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Background Kawasaki disease (KD) is an acute vasculitis disease that commonly causes acquired heart disease in children. Coronary artery aneurysm (CAA) is a major complication of KD. However, the pathogenesis of KD remains unclear. The results of a genome-wide association study (GWAS) showed that two functional single-nucleotide polymorphisms (SNPs; rs699A>G and rs5050T>G) in the angiotensinogen (AGT) gene were related to cardiovascular disease susceptibility. The purpose of our study was to estimate the relationship between the two GWAS-identified AGT gene polymorphisms and the risk of CAA in Southern Chinese children with KD. Methods We genotyped the two AGT gene polymorphisms (rs699A>G and rs5050T>G) in 760 KD cases and 972 healthy controls. We used the odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the degree of the associations. Results These two AGT gene polymorphisms were not associated with a risk of KD relative to the controls, but after adjusting for sex and age, the carriers of the rs5050G allele with TG/GG vs TT had an adjusted OR = 1.56, 95% CI = 1.01-2.41, and P = 0.044 relative to the carriers of the rs5050TT genotype. The susceptibility to CAA was more predominant in KD patients younger than 12 months old. Conclusions Our results indicate that the AGT gene polymorphism rs5050T>G may increase the risk of CAA in children with KD, especially those who are younger than 12 months. These results need to be verified by a validation study with a larger sample size.

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“…В недавно проведенном генетическом исследовании 700 литовских детей и подростков S. Simonyte и соавт. доказано влияние полиморфизма I/D гена ACE на формирование АГ у мальчиков -наличие генотипов DD и ID увеличивало риск развития АГ в 2,05 и 1,82 раза в отличие от девочек, у которых подобная ассоциация отсутствовала [26]. В выполненном нами исследовании у мужчин с АГ и носительством генотипа DD АСЕ (I/D) отмечались также более частые ранние ССЗ среди родственников по отцовской линии в сравнении с материнской линией.…”

Section: -96unclassified

Association of the I/D polymorphism of angiotensinconverting enzyme gene with the development of essential hypertension

Павлова

Ogurtsova²,

Ливенцева

et al. 2019

SMJ

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Objective. To determine the impact of the I/D polymorphism of the angiotensin-converting enzyme (ACE) gene on the development of essential hypertension, taking into account gender differences.Material and Methods. Clinical data were assessed and a molecular genetic study was performed in 602 people including 401 patients with essential hypertension and 201 individuals of the control group, representing the Belarusian ethnic group. Genotyping was performed using the method of polymerase chain reaction and restriction fragment length polymorphism.Results. The distribution of genotypes of the I/D polymorphism of the ACE gene did not differ between patients with hypertension and normotensive individuals: II, ID, and DD genotypes were detected in 100 (24.9%), 192 (47.9%), and 109 (27.2%) patients and in 52 (25.9%), 108 (53.7%), and 41 (20.4%) people of the comparison group, respectively. Differences were found between the distribution of DD genotype in men with hypertension and in the control group, where the frequencies were 28.4% and 17.3% (p = 0.04), respectively, in contrast to no differences in women: 25.8% and 23.3% (p = 0.64), respectively. Carrying the DD genotype in men compared with the ID and DD genotypes (recessive model) of the I/D polymorphism of the ACE gene increased the probability of developing essential hypertension by 1.9 times (OR = 1.89; 95% CI = 1.04-3.44). The analysis of the prevalence of risk factors depending on the I/D polymorphism of the ACE gene showed that male patients with the DD genotype more often had burdened heredity in regard to the development of premature cardiovascular diseases (23 patients (37.7%)) compared with the individuals with II and ID genotypes: 13 (21.7%) and 14 (14.9%) patients, respectively (χ2 = 1.16; p = 0.005), and mainly through the paternal line.Conclusions. Development of essential hypertension is associated with the carriership of the mutant DD genotype of I/D polymorphism of the ACE gene in men.

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Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents

Cited by 24 publications

References 60 publications

The Relationship Between Blood Pressure and Sleep Duration in Turkish Children: A Cross-Sectional Study

The Relationship Between Blood Pressure and Sleep Duration in Turkish Children: A Cross-Sectional Study

An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease

Association of the I/D polymorphism of angiotensinconverting enzyme gene with the development of essential hypertension

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