Renin secretion in essential and accelerated hypertension

Hollenberg, Norman K.; Epstein, Murray; Basch, Richard I.; Couch, Nathan P.; Hickler, Roger B.; Jp, Merrill

doi:10.1016/0002-9343(69)90200-9

Cited by 55 publications

(16 citation statements)

References 9 publications

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“…Therefore, in the present data 'renin secretion' represents the rate of renin addition to the blood leaving the kidney and not the rate at which renin is actually liberated from the juxtaglomerular apparatus. Despite these limitations the results obtained in different clinical settings are comparable (Hollenberg, Epstein, Basch, Merrill & Hickler, 1969). In our normotensive transplanted patients mean renal venous PRA was 30'5% higher than mean arterial PRA.…”

Section: Discussionmentioning

confidence: 47%

“…Similarly, Hollenberg et al (1969) have shown that in patients with chronic glomerulonephritis and pyelonephritis a significant reduction in cortical perfusion was not associated with an increase in net renin secretion. In contrast a negative correlation between the percentage of cortical blood flow and the renin secretion was found in patients with essential and accelerated hypertension (Hollenberg et al, 1969;Blaufox, Fromowitz, Lee, Meng & Elkin, 1970).…”

Section: Discussionmentioning

confidence: 86%

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Permanent Hypertension after Renal Homotransplantation in Man

et al. 1975

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1. In forty-one patients who underwent renal homotransplantation the following measurements were made: (a) blood flow and its distribution in the transplanted kidney as measured by the 85-Kr washout method; (b) renin release in the renal vein of the transplant; (c) arteriovenous difference in plasma renin activity (PRA) of the recipient's remaining left kidney. 2. Eleven transplanted patients were normotensive. Renal haemodynamic data were comparable with those obtained in potential kidney donors. 3. Three hypertensive patients had chronic rejection. The mean renal blood flow and the percentage flow in the first component of the washout curve were reduced. Renin release from the transplant, however, was normal. 4. Ten hypertensive patients had transplant artery stenosis. In eight of them renin release from the grafts as well as peripheral PRA were within normal range. This result is similar to experimental data obtained in Goldblatt renovascular hypertension. The two patients with the tightest artery stenosis had an elevated renin release from the transplant. 5. Thirteen hypertensive patients had elevated arteriovenous difference in PRA of the recipient's own left kidney. Peripheral PRA was significantly higher than in normotensive patients. Left nephrectomy relieved hypertension in ten of them; three have not so far undergone nephrectomy. 6. In four other cases hypertension was also relieved by removal of the patient's own kidney; however, the arteriovenous difference in PRA of that kidney fell within normal range.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 86%

Permanent Hypertension after Renal Homotransplantation in Man

et al. 1975

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“…Merrill conceived and initiated seminal studies that delineated the pathogenesis of renoprival hypertension and demonstrated the importance of sodium retention in its pathogenesis (27)(28)(29)(30)(31)(32). Collectively, his studies helped to establish hypertension as an integral and substantive part of the multidimensional specialty of nephrology (29 -32).…”

Section: Hypertensionmentioning

confidence: 99%

John P. Merrill

Epstein¹

2009

Clinical Journal of the American Society of Nephrology

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“…Those pathophysiologic states in which the intrarenal distribution of blood flow has been studied adequately include hemorrhagic hypotension (18), renal transplantation (21), acute renal failure (19), hepatorenal syndrome, and malignant hypertension (22). In each of these conditions, there has also been ample documentation that there is increased renin activity as well as cortical ischemia.…”

Section: Renin Activity Vs Component II the Corticomedullary Distrimentioning

confidence: 99%

Renal Blood Flow and Renin Activity in Renal Venous Blood in Essential Hypertension

Blaufox

Fromowitz

Lee

et al. 1970

Circulation Research

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The intrarenal distribution of blood flow measured by the 183 xenon washout method and the renin activity of renal venous blood were determined in 16 patients with early essential hypertension. None of the patients had evidence of systemic disease except for the elevation in blood pressure (> 150/100 mm Hg). Fifteen of the subjects received a controlled sodium diet during 7 to 9 days before study, at the time of renal angiography. An inverse relationship was noted between the cortical component of the renal blood flow and renin activity of renal venous blood (r = 0.64, P <0.02). Renin secretion rates were also calculated in 12 patients confirming the inverse relationship between cortical distribution of blood flow and renin secretion (r = 0.763, P<0.01). The cortical renal blood flow in 10 patients on a low salt intake was 79.6% ± 2.6 (SE) of the total renal blood flow. The cortical blood flow in five patients on a high salt diet was 87.6%±1.9 (SE); the statistical difference between the two groups is significant (P<0.05). A direct relationship was noted between cortical blood flow and the logarithm of the 24-hour urinary sodium excretion from the day preceding the study (r = 0.54, P<0.05). Renin secretion rate and renin in renal venous blood were directly correlated (r = 0.813, P<0.01). Changes in corticomedullary distribution of flow were inversely related to the changes in cortical distribution. The degree of reduction of cortical renal blood flow correlated with the degree of increase in renin secretion and in renin activity in renal venous blood. Our data are compatible with reduced cortical renal blood flow mediating renin release or vice versa. Either mechanism would result in more efficient conservation of salt and water by the kidney. ADDITIONAL KEY WORDSrenin release human hypertension low salt intake sodium excretion xenon washout cortical blood flow corticomedullary blood flow• The majority of pathologic conditions which are accompanied by consistent alterations in renal blood flow are also associated with changes in peripheral renin activity. Renovascular hypertension (1), acute renal failure (2), and hemorrhagic hypotension (3) are each associated with increased peripheral renin activity and with a reduction in the total

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Renin secretion in essential and accelerated hypertension

Cited by 55 publications

References 9 publications

Permanent Hypertension after Renal Homotransplantation in Man

Permanent Hypertension after Renal Homotransplantation in Man

John P. Merrill

Renal Blood Flow and Renin Activity in Renal Venous Blood in Essential Hypertension

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