2018
DOI: 10.23893/1307-2080.aps.05612
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Renoprotective and anti-oxidant effects of coleus forskohlii against gentamicin induced nephrotoxicity in albino wistar rats

Abstract: The aim of present study was to evaluate the protective effects of Coleus forskohlii against Gentamicin (GM)-induced nephrotoxicity in male albino wistar rats.Thirty rats were divided into five groups (n=6). Control rats received normal saline. Nephrotoxicity was induced in rats by gentamicin (80mg/Kg, IP) and treated with Silymarin (100mg/Kg, p.o,), aqueous and ethanolic extracts of (500mg/Kg, p.o) C. Forskohlii respectively for 15days. Markers of renal function (urea, uric acid and Creatinine), antioxidant m… Show more

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Cited by 8 publications
(8 citation statements)
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“…This is in agreement with previous studies which reported that forskolin decreased the lipid peroxidation in pre-treated erythrocytes and concluded that the antioxidant effect of forskolin could be compared with the effects of probucol and vitamin E [34]. It has been observed that in vitro forskolin increased the level of the antioxidants [19] Also there is anti-inflammatory effect of forskolin which is related to its antagonistic effect on TNFα and also by decreasing the level of inflammatory mediators as histamine, interleukins (IL-1β,IL-4, IL-6, IL-8), leukotriene (LT-4), antigens [30].…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…This is in agreement with previous studies which reported that forskolin decreased the lipid peroxidation in pre-treated erythrocytes and concluded that the antioxidant effect of forskolin could be compared with the effects of probucol and vitamin E [34]. It has been observed that in vitro forskolin increased the level of the antioxidants [19] Also there is anti-inflammatory effect of forskolin which is related to its antagonistic effect on TNFα and also by decreasing the level of inflammatory mediators as histamine, interleukins (IL-1β,IL-4, IL-6, IL-8), leukotriene (LT-4), antigens [30].…”
Section: Discussionsupporting
confidence: 93%
“…Rats were randomly divided into four groups. Rats in the control group received distilled water orally for 15 days, four days before scarification they received half the dose of saline (10 ml/kg) in each hind limb muscle; rats in the forskolin (FSK) group received 500 mg/kg per day, orally for 15 days [19]; those in the AKI group received half the dose of glycerol (10 ml/kg, 50% v/v in sterile saline) in each hind limb muscle [20]; rats in the FSK + AKI group received forskolin 500 mg/kg/day orally for 12 days before glycerol injection and three days after glycerol injection with a total period for 15 days. Three days after glycerol injection, all rats were sacrificed under general anesthesia using intraperitoneal injection of pentobarbital sodium (150 mg/kg.…”
Section: Experimental Designmentioning
confidence: 99%
“…Experimental animals were divided into 12 groups for testing hepatoprotective activity and 12 groups for testing nephroprotective activity with each group consisting of 10 animals. Table 1 shows the treatment given to each group of experimental animals for 10 days and after 10 days [ 27 ], [ 28 ], [ 29 ], [ 30 ], [ 31 ].…”
Section: Methodsmentioning
confidence: 99%
“…The blood samples obtained were centrifuged at 3000 rotations per minute for 15 minutes. Serum obtained were used for the biochemical analysis with hepatoprotective activity parameters (alanine transaminase and aspartate transaminase) and nephroprotective activity parameters (urea and creatinine) [ 27 ], [ 28 ], [ 29 ], [ 30 ], [ 31 ]. The biochemical analysis of hepatoprotective activity parameters (alanine transaminase and aspartate transaminase) and the biochemical analysis of nephroprotective activity parameters (urea and creatinine) were carried out by the standard method from Sigma Aldrich.…”
Section: Methodsmentioning
confidence: 99%
“…Ma et al 4 determined the anti-inflammatory activity of a Coleus forskohlii extract used for the treatment of asthma and of the upper airways due to the modulation of inflammatory cytokines and concluded that this phytotherapeutic compounds can be potentially applied to the treatment of asthmatic conditions. Other studies indicated that the antioxidant potential and other medicinal properties of Coleus forskohlii extrat may act as renal protectors and preserving agents against the oxidative deterioration induced by degenerative dieases 5 .…”
Section: Introductionmentioning
confidence: 99%