Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats

Abdelrahman, Rehab S.; Abdelmageed, Marwa E.

doi:10.1016/j.cbi.2019.108863

Cited by 30 publications

(20 citation statements)

References 55 publications

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“…On the contrary, activation of NF-κB can induce the expression of many proinflammatory genes, including COX-2, TNF-α, IL-6 and iNOS 38 . Previous studies have shown that GM can induce severe inflammatory reactions, including activation of NF-κB and iNOS, and the production of TNF-α 39 . In this study, GM exposure significantly increased NF-kB protein expression and increased TNF-α and IL-6 levels (Fig.…”

Section: Discussionmentioning

confidence: 99%

Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway

Wang

Wang³

et al. 2020

Sci Rep

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Although gentamicin is widely used as an antibiotic in clinical practice, it also has some side-effects, such as acute kidney injury, which is a common condition caused by the abuse of gentamicin. Sika deer antler protein (SDAPR) can antagonize drug-induced AKI. Since SDAPR is recognized as an effective part of velvet antler, its components were further separated. Two components named SDAP1 and SDAP2 were obtained. The protective effects of SDAPR, SDAP1 and SDAP2 on GM-induced cytotoxicity to HEK293 and its potential mechanisms were studied. MTT and xCELLigence Real-Time cell analysis showed that SDAPR, SDAP1 and SDAP2 could protect HEK293 cells from GM toxicity. Similarly, SDAPR, SDAP1 and SDAP2 can reduce ROS level, reduce oxidative stress and improve inflammation Further studies have shown that SDAPR, SDAP1 and SDAP2 upregulate the Nrf2/HO-1 pathway by increasing the expression of Nrf2 and HO-1, and down-regulate the NF-κB pathway by reducing the protein expression of NF-κB. Annexin V/PI flow cytometry and Hoechst 33258 staining showed that SDAPR, SDAP1 and SDAP2 inhibited GM-induced apoptosis in HEK293 cells. Western blot analysis showed SDAPR, SDAP1 and SDAP2 decreased expression level of Bax and Cleaved-caspase-3, and increased the expression level of Bcl-2. In addition, we examined the feasibility of SDAP1 and SDAP1 to avoid kidney injury in a GM mouse model. In conclusion, SDAPR, SDAP1 and SDAP2 can be used to prevent GM-induced HEK293 cytotoxicity, probably because they have strong anti-oxidative stress, anti-inflammatory and anti-apoptotic effects. And SDAP1 and SDAP2 can inhibit GM-induced acute kidney injury in mice.

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Section: Discussionmentioning

confidence: 99%

Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway

Wang

Wang³

et al. 2020

Sci Rep

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“…The separate sera were sucked into clean dried weatherman tubes by automatic pipette and re‐centrifuged for 5 min at 2,146.56 g . The serum samples were used for measurement of biochemical analyses of serum alanine aminotransferases (ALT), aspartate aminotransferase (AST) activities according to the procedure applied by Reitman and Frankel () and Primus, Akoolo, Schlachter, and Parveen (), uric acid (mg/dl) and creatinine (mg/dl) measured regarding to the method described by Bartels, Böhmer, and Heierli () and Abdelrahman and Abdelmageed (). by spectrophotometric technique, using commercial kits obtained from Vitro Scient Co., Germany.…”

Section: Methodsmentioning

confidence: 99%

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Elgeddawy¹,

Shaheen

El‐Sayed

et al. 2020

Animal Physiology Nutrition

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We evaluated the effect of prebiotic or probiotic as feed additives on florfenicol kinetic in broilers feed. Unsexed two hundred, thirty‐five‐day‐old broiler chickens, were put in four equal groups (n = 50). The first group was administrated florfenicol intravenous at 30 mg/kg body weight (BW) only once dosage without pre‐ or probiotic administration to determine the bioavailability. While, the second group was administrated florfenicol (intracrop routes; a dosage of 30 mg/kg BW for five progressive days) without pre‐ or probiotic co‐administration. The third and the fourth groups were administrated the same dose of florfenicol (intracrop route) for five successive days, followed by 10 days of prebiotic or probiotic treatment respectively. The plasma florfenicol % was identified by high‐pressure liquid chromatography (HPLC) after the first florfenicol administration (intravenous or intracrop routes) in all groups. Then, the residual levels of florfenicol were determined in liver, kidney and muscle tissues from the second, third and fourth groups which were exposed to florfenicol orally. Our results demonstrated that broilers pre‐treated with prebiotic or probiotic significantly increased Cmax, AUC0–t, AUC0–inf as well as AUMC values, while significant drop was recorded in V/F and CL/F. Prebiotic or probiotic influenced the cumulative effect of florfenicol in liver and kidney tissues of treated birds.

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“…Such a disorder can cause increased levels of MDA in the blood serum and tissues. In 2020, Abdelrahman et al showed that GM induced oxidation of lipids in renal and hepatic tissues and increased serum levels of MDA 21 . In a recent study, GM also induced an increase in serum MDA.…”

Section: Discussionmentioning

confidence: 98%

Human umbilical cord blood serum attenuates gentamicin‐induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats

Mirazi

Baharvand

Moghadasali

et al. 2020

Basic Clin Pharma Tox

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is an aminoglycoside antibiotic. Despite its clinical effects, its application has been restricted due to adverse side effects. The application of this antibiotic is a prevalent cause of acute renal failure in about 10 to 20% of the consumers. 1 Apart from the renal effects, GM also has hepatic effects that induce apoptosis and increase the activity of the reactive oxygen species (ROS). 2 Acute hepatic deficiencies caused by medication are associated with the rapid loss of hepatic function as well as high mortality rate. Currently, for the advanced conditions of the disease, the only alternative is the liver transplantation which due to the shortage of donors and rejection problems presents itself as a huge challenge. 3 However, in recent years, cell therapies utilizing stem cells-due to their inherent ability to repair damaged tissues and organs-have shown remarkable progress in advancing the recovery of damage and disability of organs and tissues. 4 Having said that, the use of stem cells and their administration to patients entail serious risks and side effects such

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Renoprotective effect of celecoxib against gentamicin-induced nephrotoxicity through suppressing NFκB and caspase-3 signaling pathways in rats

Cited by 30 publications

References 55 publications

Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway

Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway

Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken

Human umbilical cord blood serum attenuates gentamicin‐induced liver toxicity by restoring peripheral oxidative damage and inflammation in rats

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