Renoprotective Effect of Egyptian Cape Gooseberry Fruit (Physalis peruvianaL.) against Acute Renal Injury in Rats

Abstract

This study aimed to evaluate the renoprotective effect of Physalis peruviana L. extract (PPE) on acute renal injury in rats. Adult male rats (n = 36) were divided into six groups that were fed with basal diet throughout the experiment (33 days). The first group was normal group, the second and the third groups were administered orally with 100 and 150 mg PPE/kg body weight (BW) respectively, the fourth group was injected intraperitoneally with 5 mg/kg BW cisplatin once on the 28th day to induced ARI, and the fifth and sixth groups were treated like the second and the third groups and were injected with cisplatin on the 28th day. Many bioactive compounds were found in PPE. PPE did not cause any changes in the second and third groups compared to normal control group. Administration of PPE prior to cisplatin injection caused significant reduction in relative kidney weight, serum creatinine, urea, blood urea nitrogen, and significant increments in body weight, feed intake, total protein, albumin, and total globulin compared to cisplatin group. Pretreatment with PPE improved kidney histology and diminished the level of thiobarbituric acid reactive substances and enhanced other antioxidant enzymes in kidney homogenate compared to cisplatin group.

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

“…According to the results, the administration of a single dose of Streptozotocin (50 mg/kg weight body) increased water consumption. Other studies have shown that diabetes mellitus is characterized by classical symptoms such as polyphagia, and polydipsia which are exhibited in HFD-STZ diabetic rats and this may be attributed to the impaired glucose homeostasis as a result of insulin inefficiency (Akbarzadeh et al, 2007). Water consumption was inversely related to food intake, this was an indication that the decrease in food intake in diabetic animals was linked to the significant amount of sugars in the blood that had an impact on the index of satiety.…”

“…A phytochemical screening in regeneration plant, callus from seed, leaf and fruits from mother plants of P. peruviana, showed the present of alkaloids, glycosides, cardiac glycosides, saponins, phenol, sterol, tannins, flavonoids and diterpene (Lashin and Elhaw, 2016). A phytochemical investigation of the crude ethanolic extract of P. peruviana L. revealed the presence of phenols, flavonoids, phytosterols, glycosides, sterols, saponins, tannins and alkaloids (Ahmed, 2014). Previous phytochemical studies have isolated a number of compounds from P. peruviana, such as ticloidine, withanolides, phenolics and phytosterols (Gautam et al, 2015).…”

“…franchetii (Yu et al, 2013). Withanolides are natural steroidal lactones produced mainly by plants in the Solanaceae that often have many health benefits such as antiinflammatory activity (Ahmed, 2014). Physalis (L.) species contains various carbohydrates, lipids, minerals, vitamins and phytosteroles (Sharma et al, 2015).…”

“…The animal experiment protocols was carried out in accordance with the guidelines of the ICH on preclinical pharmaceutical testing in mouse (OECD, 2001;Akbarzadeh et al, 2007).…”

Comprehensive two-dimensional gas chromatography and three-dimensional fluorometry for detection of volatile and bioactive substances in some berries

“…The consumption of berries has been linked to the prevention of some chronic and degenerative diseases. The term 'berry fruits' encompasses the so-called 'soft fruits', enhanced other antioxidant enzymes in kidney homogenate compared to cisplatin group [15]. The mechanism of the consumption of the berries and their influence on metabolism were not studied.…”