Natural medicines for acute renal failure: A review

Boozari, Motahareh; Hosseinzadeh, Hossein

doi:10.1002/ptr.5943

Cited by 34 publications

(25 citation statements)

References 93 publications

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“…Natural medicines are widely employed in the prevention and treatment of various diseases (Boozari & Hosseinzadeh, 2017;Hoenders et al, 2018;Li et al, 2018). MS is considered to be the most helpful tool to bridge the gap between herbal medicines and modern molecular biology.…”

Section: Drug Metabolism and Mechanisms Of Actionmentioning

confidence: 99%

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Wang

Ren

Zhang

et al. 2019

Mass Spectrometry Reviews

103

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Current evidence shows that herbal medicines could be beneficial for the treatment of various diseases. However, the complexities present in chemical compositions of herbal medicines are currently an obstacle for the progression of herbal medicines, which involve unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, non‐specific features for drug metabolism, etc. To overcome those issues, metabolomics can be a great to improve and understand herbal medicines from the small‐molecule metabolism level. Metabolomics could solve scientific difficulties with herbal medicines from a metabolic perspective, and promote drug discovery and development. In recent years, mass spectrometry‐based metabolomics was widely applied for the analysis of herbal constituents in vivo and in vitro. In this review, we highlight the value of mass spectrometry‐based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, and to enhance their biomedical value in biomedicine, to shed light on the aid that mass spectrometry‐based metabolomics can offer to the investigation of its active ingredients, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. © 2019 Wiley Periodicals, Inc. Mass Spec Rev

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Section: Drug Metabolism and Mechanisms Of Actionmentioning

confidence: 99%

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Wang

Ren

Zhang

et al. 2019

Mass Spectrometry Reviews

103

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“…These results are supported based on the well-established use of antioxidant substances to prevent oxidative stress and concomitant inflammation [12]. Natural products and phytochemical compounds with inhibitory effects on antioxidant mechanisms have shown beneficial influence in models of IR-induced AKI [13–15].…”

Section: Introductionmentioning

confidence: 96%

Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats

Oyarzábal-Yera

Rodríguez-Salgueiro

Merino-García

et al. 2019

Kidney Res Clin Pract

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BackgroundAcute kidney injury (AKI) induced by renal ischemia/reperfusion (IR) is associated with enhanced production of reactive oxygen species in renal tissues. D-005, a lipid extract obtained from Acrocomia crispa fruit, has previously shown antioxidant effects. The aim of this work was to evaluate the effects of D-005 on renal IR-induced AKI in rats.MethodsRats were randomized into seven groups including a negative control group (vehicle) without AKI and six groups with renal IR-induced AKI as follows: a positive control (vehicle); D-005 treatment at 25, 100, 200, or 400 mg/kg; and dexamethasone at 3 mg/kg. All treatments were orally administered as single doses 1 hour before AKI induction. Biomarkers (serum creatinine, urea, and uric acid concentrations), oxidative variables, and histopathological AKI changes were evaluated in blood and kidney tissues.ResultsAll D-005 doses protected against IR-induced AKI in rats by significantly decreasing biomarkers and histopathological AKI changes as assessed by reduced serum concentrations of creatinine, urea, and uric acid. In addition, all D-005 doses decreased tubular damage, as shown by fewer detached cells and casts in the tubular lumen. D-005 reversed oxidation disturbance markers by decreasing malondialdehyde and sulfhydryl group concentrations in plasma and in kidney homogenates and by increasing kidney catalase activity. Dexamethasone, the reference substance, protected against IR-induced AKI in rats by reducing biochemical and histological variables of renal damage in a similar manner.ConclusionAdministration of single oral doses of D-005 markedly and significantly protected against renal IR-induced AKI, possibly due to its known antioxidant effects.

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“…Renal ischemia is commonly seen in patients with cardiovascular surgery, trauma, shock, burn, and organ transplantation [ 1 , 2 ]. The ischemia-reperfusion (I/R) injury causes molecular and cellular inflammatory response within the kidney, such as activation of inflammatory-relevant transcription factor, nuclear factor-κB (NF-κB) which plays an important role in pathogenesis of I/R injury [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

Zhang

Tang

et al. 2018

Renal Failure

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The present study aimed to explore the protective mechanism of curcumin-precondition in renal ischemia-reperfusion (I/R) injury. Thirty male SD rats were randomly equally divided into Sham, IRI, and Curcumin groups (n = 10). The model of IRI was induced by clamping the left renal artery for 45 min followed by 24 h reperfusion with the contralateral nephrectomy. ELISA was used to examine the expression of Cr, BUN, IL-8, TNF-α, and IL-6 in the serum; RT-PCR was used to detect the mRNA level of IL-8,TNF-α, and IL-6 in the kidney; The morphology of kidney was examined by Periodic Acid-Schiff stain (PAS). The expression of JAK2, p-JAK2, STAT3, p-STAT3, p65, and p-p65 in kidney were detected by Western blotting. The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-α, IL-6, and p-p65. In addition, Curcumin can attenuate the kidney pathological injury and have no effect on the expression of JAK2, STAT3, and p65. Our findings showed the protective effect of Curcumin in I/R injury is associated with suppressing NF-κB mediating inflammation by activating JAK2/STAT3 signal pathway.

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Natural medicines for acute renal failure: A review

Cited by 34 publications

References 93 publications

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats

The anti-inflammatory effects of curcumin on renal ischemia-reperfusion injury in rats

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