Renoprotective effect of <i>Corallocarpus epigaea</i> in Nephropathy in Wistar Rats

The research study designed to investigate the nephroprotective efficiency of Calotropis gigantea stem bark extract. Streptozotocin (60 mg/kg/ i.p) diabetes model was used to evaluate the Nephropathy potential of Calotropis gigantea in animals. After single administration of STZ nephropathic complication develops within four weeks. Nephropathy was assessed by blood urea nitrogen, increasing serum creatinine level, microproteinuria, lipid alteration and high renal oxidative stress. Calotropis gigantea stem bark extract shows prominent nephroprotective effect at high dose (500 mg/kg p.o) as compared to low dose treatment (200 mg/kg p.o) in experimentally induced diabetic nephropathy in rats. The present study indicated the plant having of medicinally significant bioactive constituents that shows tremendous nephroprotective effect. It is concluded that stem bark extract of Calotropis gigantea had a role in diabetes control and impedes the continuation of diabetes-induced experimental nephropathy.

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Plant Calotropis gigantea: Management of Diabetic Nephropathy in Experimentally Induced Diabetes in Rats

Kumar

Sharma

Vasudeva

2022

RJPT

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Delayed Structure – function alterations in Pancreas and Liver of Rodent Diabetic Model treated with Salacia oblonga.

Bhat

Raghuveer

D’Souza

et al. 2023

RJPT

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Salacia oblonga (S. oblonga) is a component of several antidiabetic medications in alternative and folklore medicine. An evaluation of the hydroalcoholic root extract of S.oblonga (SOE) on the hepatocellular and pancreatic environment in the diabetic (Streptozotocin) rodent model was designed. SOE was fed in two doses for a period of 16 weeks. Regeneration of endocrine pancreas, significant increase in hepatic and pancreatic Vitamin C, reduced Glutathione (GSH), Protein thiols (PT) and decrease in Malondialdehyde (MDA measured as TBARS) and Carbonyl proteins (CP) were observed on treatment with SOE. Conversely, there was also an increase in alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT). Corroborating the above findings, histopathological examination of the liver and pancreatic tissue showed disrupted architecture in treated rats. It may be suggested that SOE has a sustained hepatic antioxidant effect and improved β-cell structure and function in diabetic rats, but the higher dose was mildly toxic to hepatocytes necessitating an exercise of caution in using SOE for therapy for prolonged periods.

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Evaluation of Nephroprotective effect of Ubiquinol on Ifosfamide Induced Nephrotoxicity in Albino Wistar Rats

Anuhya,

Mohanbabu Vittalrao,

Kamalkishore

et al. 2024

RJPT

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To determine nephroprotective activity of ubiquinol on ifosfamide induced renal damage by measuring the oxidative stress, biochemical parameters and histopathological examination. Thirty-six rats were divided into 6 groups, Group 1 rats were treated with 2ml of corn oil (vehicle) p.o., Group 2 and 3 received only ubiquinol of 10mg/kg/day and 50mg/kg/day respectively. Ubiquinol was prepared as oral suspensions with 2ml of corn oil. Group 4 received ifosfamide 80mg/kg/day, i.p. for 3 days. Groups 5 and 6 also received ubiquinol 10mg/kg/day and 50mg/kg/day respectively p.o. for 14 days. Then, we added ifosfamide to both the groups and dosed concomitantly along with ubiquinol from 8th -10th day. Ubiquinol proved to be an effective renoprotectant by decreasing the kidney to body weight ratio in ubiquinol treated IFO groups as compared to IFO group (p<0.05). Biochemical tests done on day 9 revealed that there was no significant difference in levels of Sr.Creatinine and total protein, but the levels of BUN were found to be significantly higher in IFO treated groups as compared to corn oil group (p<0.05). On day 15, it was seen that significant improvement in Sr.Creatinine, BUN and total protein levels of ubiquinol treated IFO groups as compared to IFO group (p<0.01). The levels of MDA and GSH were reversed in ubiquinol treated IFO groups as compared to IFO group (p<0.01). Histopathological examination supported that ubiquinol preserved the normal architecture of kidney in ubiquinol treated IFO groups. Ubiquinol proved to be an effective nephroprotective agent against ifosfamide induced nephrotoxicity.

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Renoprotective effect of Corallocarpus epigaea in Nephropathy in Wistar Rats

Cited by 5 publications

References 0 publications

Plant Calotropis gigantea: Management of Diabetic Nephropathy in Experimentally Induced Diabetes in Rats

Plant Calotropis gigantea: Management of Diabetic Nephropathy in Experimentally Induced Diabetes in Rats

Delayed Structure – function alterations in Pancreas and Liver of Rodent Diabetic Model treated with Salacia oblonga.

Evaluation of Nephroprotective effect of Ubiquinol on Ifosfamide Induced Nephrotoxicity in Albino Wistar Rats

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