Renoprotective Effects of <i>Origanum majorana</i> Methanolic L and Carvacrol on Ischemia/Reperfusion‐Induced Kidney Injury in Male Rats

Gheitasi, Izadpanah; Azizi, Arash; Omidifar, Navid; Doustimotlagh, Amir Hossein

doi:10.1155/2020/9785932

Cited by 18 publications

(19 citation statements)

References 34 publications

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“…Our results indicated that plasma PCO, as an early index of protein oxidation, markedly elevated in the I/R group in contrast to SC rats, while SP extract (500 mg/kg) significantly reduced it. In agreement with previous studies [ 11 , 35 ], protein oxidation happens in I/R-induced renal damage. Kang et al (2006) observed that ROSs play a vital role in the pathogenesis of I/R damage [ 6 ].…”

Section: Discussionsupporting

confidence: 93%

“…In previous studies, the protective impact of Malva sylvestris L. [ 10 ], Origanum majorana L. [ 11 ], and Salvia miltiorrhiza [ 12 ] have been explored on the I/R-induced damage. Stachys pilifera Benth ( SP ) is one of genera in the family of Lamiaceae, and the genus Stachys is distributed in the tropical and subtropical regions [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats

Moslemi

Gheitasi

Doustimotlagh

2021

Journal of Toxicology

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Background. Renal ischemia-reperfusion (I/R) has a pivotal role in the progression of acute renal failure. Reactive oxygen species are considered the major constituents involved in the biochemical and pathophysiological changes that were shown during kidney I/R. The purpose of this study was to examine the renoprotective effects of Stachys pilifera ethanolic extract on oxidant-antioxidant status in renal I/R-injuries in male rats. Material and methods. Twenty-one male Wistar rats were arbitrarily distributed into 3 groups: sham control (SC), I/R, and I/R + Stachys pilifera ethanolic extract (500 mg/kg). The artery and vein of the right kidney were completely blocked, and the right kidney was completely removed in all groups. Then, the left kidney artery was blocked with suture thread for 30 minutes in only I/R and I/R + SP extract groups. Kidney function indices, oxidative stress markers, and hematoxylin and eosin staining were investigated in the plasma and kidney tissues. Results. It was shown that the urine Na and K, fractional excretion of Na and K, and protein carbonyl content markedly increased in the merely I/R group as compared to SC rats, while the administration of SP extract markedly reduced these indices ( P < 0.05 ). Also, glomerular filtration rate and total thiol meaningfully reduced in the I/R rats in contrast to the SC group, while the treatment with SP extract markedly augmented these indices ( P < 0.05 ). However, in agreement with renal function tests, SP extract had no significant effects on histopathological examinations. Conclusion. It seems that SP extract employs renoprotective effects on renal damage induced by I/R, possibly by improving of oxidant-antioxidant status in favor of the antioxidant system.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats

Moslemi

Gheitasi

Doustimotlagh

2021

Journal of Toxicology

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“…The harmful effects of ROS can be explained by several mechanisms; they may produce cellular injury including peroxidation of membrane lipids, protein denaturation, and DNA damage [ 45 – 47 ]. The most sensitive compounds against oxidative stress are lipids.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Hydroalcoholic Extract of Rosa canina Fruit on Vancomycin-Induced Nephrotoxicity in Rats

Sadeghi

Karimizadeh

Sadeghi

et al. 2021

Journal of Toxicology

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Vancomycin-induced nephrotoxicity (VIN) has been reported to occur in 5–35% of recipient patients. The aims of the study were to evaluate protective effects of Rosa canina (RC) on VIN in rats. Rats were randomly divided into five groups as follows: control group I, group II (received VAN 400 mg/kg/day, every 12 h at doses of 200 mg/kg/day, for 7 consecutive days), group III (VAN + RC 250 mg/kg/day, for 7 consecutive days), group IV (VAN + RC 500 mg/kg/day, for consecutive days), and group V (received RC 500 mg/kg/day, for consecutive 7 days). On the eighth day after anesthetizing the animals, blood samples were taken from the heart, and then, the kidneys were removed to investigate kidney function, oxidative stress, and histopathological marker. Also, the chemical composition of RC extract was identified by GC-MS analysis. Oral dose of 500 mg/kg RC extract significantly reduced the serum levels of blood urea nitrogen (BUN), creatinine (Cr), malondialdehyde (MDA), and nitric oxide (NO) and also the kidney tissue MDA, protein carbonyl, and NO metabolites (nitrite) levels compared to the VAN-treated group ( P < 0.05 ). Based on histopathological analysis, RC extract at the dose of 500 mg/kg inhibited the destructive effects of VAN on kidney tissues. GC-MS analysis indicated that the main compositions were found to be lactose (21.96%), 3-t-butyloxaziridine (20.91%), and 5-oxymethylfurfurole (16.75%). The results indicated that oral administration of RC was able to reduce VAN-induced nephrotoxicity in rats, possibly through antioxidant pathways.

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“…Different factors can affect cell senescence and the progression of age-related diseases ( Figure 1 ). Oxidative stress is one of the key factors involved in cell damage or injury [ 5 , 6 ]. Endogenous or exogenous agents could induce tissue or organ damage via oxidative stress [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Trends in Natural Nutrients for Oxidative Stress and Cell Senescence

Omidifar

Moghadami

Mousavi

et al. 2021

Oxidative Medicine and Cellular Longevity

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Due to the increase in the aged population and increased life expectancy, the underlying mechanisms involved in the aging process and cell senescence and the ways for modulating these processes in age-related diseases become important. One of the main mechanisms involved in aging and cell senescence, especially in the diseases related to aging, is the oxidative stress process and the following inflammation. Hence, the effects of antioxidants are highlighted in the literature due to their beneficial impacts on inhibiting telomere shortening or DNA damage and other processes related to aging and cell senescence in age-related diseases. Dietary components, foods, and dietary patterns rich in antioxidants can modulate the aging process and delay the progression of some chronic diseases such as cardiovascular diseases, diabetes, and Alzheimer’s disease. Foods high in polyphenols, vitamin C, or carotenoids, olive oil, seeds, nuts, legumes, dietary supplements such as CoQ10, and some other dietary factors are the most important nutritional sources that have high antioxidant contents which can positively affect cell senescence and disease progression. Plant dietary patterns including Mediterranean diets can also inhibit telomere shortening following oxidative damages, and this can delay cell aging and senescence in age-related diseases. Further, olive oil can inhibit protein aggregation in Alzheimer’s disease. It can be concluded that nutrition can delay the process of cell senescence in age-related diseases via inhibiting oxidative and inflammatory pathways. However, more studies are needed to better clarify the underlying mechanisms of nutrition and dietary components on cell senescence, aging, and disease progression, especially those related to age.

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Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion‐Induced Kidney Injury in Male Rats

Cited by 18 publications

References 34 publications

Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats

Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats

Protective Effects of Hydroalcoholic Extract of Rosa canina Fruit on Vancomycin-Induced Nephrotoxicity in Rats

Trends in Natural Nutrients for Oxidative Stress and Cell Senescence

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