Reoxygenierung humaner koronarer glatter Muskelzellen inhibiert die HIF-1α-Genexpression und steigert die radiogene Wachstumsverzögerung und Apoptose

Abstract

Reoxygenation of coronary smooth muscle cells should be considered an option to increase efficacy of coronary brachytherapy. This could be used to reduce radiation dose and associated late side effects.

Age-dependent changes in oxygen tension, radiation dose and sensitivity within normal and diseased coronary arteries–Part C: Oxygen effect and its implications on high- and low-LET dose

“…The O 2 and OER models developed predict that the biological effectiveness of irradiated individuals with CVD can be smaller by up to 51% than the radiation dose alone implies, due to hypoxia in diseased avascular walls. An undesirable example of the oxygen effect is where radioisotopes are incorporated into intracoronary stents and the biological effect of the dose has been experimentally shown to be less than expected when treating diseased coronary arteries (Grumann et al 2006). The results determined analytically here are in agreement with the experimental studies showing underdosing by low-LET gamma-and beta-radioactive stents.…”

“…Gamma emitting ( 166 Ho,192 Ir) and beta-emitting ( 32 P, 90 Sr) intracoronary stents have led to a significant reduction in restenosis (Li et al 2000). Experimental studies by Grumann et al (2006) found that restenosis may be reduced by accounting for the underdosing that can result from deploying a radioactive stent under hypoxic conditions.…”

HLA Class II Alleles and the Presence of Circulating Epstein-Barr Virus DNA in Greek Patients with Nasopharyngeal Carcinoma

“…Using nested PCR [15,45], Lin et al detected EBV-DNA in peripheral whole blood in 71% of NPC patients (88/124), but only in 14% of healthy volunteers (16/114) [27]. Several other groups have also reported the detection of cell-free EBV-DNA in the serum or plasma of NPC patients and healthy controls, with highly variable detection rates from 31% to 96% for NPC patients and from 0% to 14% for healthy controls [30,35,43].…”

The Role of Survivin for Radiation Therapy

“…Causing irreparable cellular damage triggering apoptosis is a key mechanism by which chemotherapy and ionizing radiation kill tumor cells [6,20,62]. Alterations in the expression of apoptosis-related proteins, like the inhibitor of apoptosis (IAP) protein family, however, influence the response to anti-cancer treatment.…”