Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant

Yoneda, Masahiro; Terai, Hidetomi; Imai, Yuuki; Okada, Takao; Nozaki, Kazutoshi; Inoue, Harumi; Miyamoto, Shimpei; Takaoka, Kunio

doi:10.1016/j.biomaterials.2005.01.054

Cited by 94 publications

(66 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, it is known that dense materials without pores exhibit little degradation, preventing suitable matrix deposition and mineralization, a structure with interconnections or porous (Komaki et al). In the case of β-TCP, these present porous that permit the infiltration of osteogenic cells and angiogenesis: in addition, the porosity of the β-TCP is crucial to its rapid degradation, facilitating contact with host cells and resulting increased contact of osteoclastic cells with the material; the ability of these cells to penetrate and reabsorb the β-TCP contributes to the replacement of the biomaterial for bone tissue (Yoneda et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study

et al. 2017

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study

et al. 2017

View full text Add to dashboard Cite

“…[20][21][22] . However, little is known about the molecular basis for the incorporation process of β-TCP into the healing of the bone tissue.…”

Section: Microfibrils Have Clinical Significance As Mutations In the mentioning

confidence: 99%

Involvement of MAGP1 in ^|^beta;-TCP Enhanced Bone Regeneration

Lin

Bhawal

Watanabe

et al. 2012

J. Hard Tissue Biology.

View full text Add to dashboard Cite

Microfibril-associated glycoprotein-1 (MAGP1) is a small molecular weight, ubiquitous component of the fibrillin-rich microfibrils that found in the extracellular matrix. Inactivation of MAGP1 results in a bleeding diathesis and an altered wound healing response in bone and skin. Beta-tricalcium phosphate (β-TCP) is widely used in clinical orthopedic surgery due to its high biodegradability, osteoconductivity, easy manipulation and lack of histotoxicity. In this study, we aimed to understand the differential expression of MAGP1 in bone tissue implanted with β-TCP. Following the extraction of premolars and subsequent bone healing,β-TCP was implanted into the artificial osseous defect of dog mandibles. Bone tissue specimens were collected at 4 and 7 days after implantation. Total RNA was isolated from bone tissue, and gene expression profiles were analyzed using microarray technology. MAGP1 mRNA was up-regulated at days 4 and 7 in β-TCP-implanted tissues compared to the controls. Real-time PCR was used to confirm the mRNA levels. Immunohistochemical analysis revealed a higher expression in MAGP1 protein at day 7 in b-TCP-implanted tissues compared to the control. These results suggest that MAGP1 might be involved in the early stage of β-TCP enhanced bone regeneration.

show abstract

“…β-TCP is routinely used as bone replacement, especially in the field of oral and craniofacial surgery, in the form of granules and rods [14,15] or as filler in polymeric scaffolds [16]. In bulk, β-TCP bioceramics have mechanical properties too poor to be used in load-bearing clinical applications [17][18][19], which has been attributed to the difficulties in fully densifying β-TCP powders [18,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Densification and Mechanical Behavior of β-Tricalcium Phosphate Bioceramics

Mehdikhani

Borhani

2014

ILCPA

View full text Add to dashboard Cite

Nano-size β-tricalcium phosphate powders with average grain size of 80 nm were prepared by the wet chemical precipitation method with calcium nitrate and di-ammonium hydrogen phosphate as calcium and phosphorus precursors, respectively. The precipitation process employed was also found to be suitable for the production of sub-micrometre β-TCP powder in situ. The sinterability of the nano-size powders, and the microstructure, mechanical strength of the prepared β-TCP bioceramics were investigated. Bioceramic sample characterization was achieved by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), and density measurements. Powders compacted and sintered at 800, 900, 1000 and 1100 °C showed an increase in relative density from 70 % to 93 %. The results revealed that the maximum hardness of 240 H V was obtained for β-TCP sintered at 1100 °C.

show abstract

Repair of an intercalated long bone defect with a synthetic biodegradable bone-inducing implant

Cited by 94 publications

References 21 publications

Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study

Evaluation of Decellularized Matrix and ß-Tricalcium Phosphate as Biomaterials for Bone Neoformation: In vivo Study

Involvement of MAGP1 in ^|^beta;-TCP Enhanced Bone Regeneration

Densification and Mechanical Behavior of β-Tricalcium Phosphate Bioceramics

Contact Info

Product

Resources

About