2021
DOI: 10.1101/2021.04.19.440506
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Repair of critical-size porcine craniofacial bone defects using a collagen-polycaprolactone composite biomaterial

Abstract: Regenerative medicine approaches for massive craniomaxillofacial bone defects face challenges associated with the scale of missing bone, the need for rapid graft-defect integration, and challenges related to inflammation and infection. Mineralized collagen scaffolds have been shown to promote mesenchymal stem cell osteogenesis due to their porous nature and material properties, but are mechanically weak, limiting surgical practicality. Previously, these scaffolds were combined with 3D-printed polycaprolactone … Show more

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Cited by 4 publications
(2 citation statements)
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“…The mechanics of low-density open-cell foams dictates that scaffold micromechanics required to support cell activity yields sub-optimal macroscale mechanical performance [52]. As a result, we have separately reported a reinforcement strategy that incorporates macroscale reinforcement mesh architectures into these scaffolds to support surgical practicality [53, 54]. These meshes do not influence scaffold microarchitecture or negatively affect cell activity in scaffolds and were not included in this study as we focused on modification to scaffold composition.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanics of low-density open-cell foams dictates that scaffold micromechanics required to support cell activity yields sub-optimal macroscale mechanical performance [52]. As a result, we have separately reported a reinforcement strategy that incorporates macroscale reinforcement mesh architectures into these scaffolds to support surgical practicality [53, 54]. These meshes do not influence scaffold microarchitecture or negatively affect cell activity in scaffolds and were not included in this study as we focused on modification to scaffold composition.…”
Section: Discussionmentioning
confidence: 99%
“…The healing often fails when the large bone defect exceeds host self-repair capacity, especially for those with trauma, congenital anomalies, and tissue resection due to cancer [ [3] , [4] , [5] ]. Conventional surgical reconstructive procedures using autograft or allograft bone tissues may repair the defects to some degree in anatomical and functional outcomes [ 6 , 7 ]. But these treatment options occasionally bring with some considerable risks to the patients [ [8] , [9] , [10] , [11] ].…”
Section: Introductionmentioning
confidence: 99%