Repair of erosions in patients with rheumatoid arthritis treated with etanercept: magnetic resonance imaging findings after 1 year of follow-up

Lisbona, MP; Maymó, Joan; Solano, A.; Almirall, Míriam; Navallas, María; Ares, Jesús; Carbonell, Jordi

doi:10.3109/03009742.2013.776104

Cited by 9 publications

(8 citation statements)

References 27 publications

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“…The OMERACT Subcommittee on Repair states that although SDC values are too large to be useful for determining repair at an individual patient level, using the SDC is currently appropriate . Previous reports revealed that a very small number of RA patients show negative changes in MRI erosion scores that exceed the SDC during therapy with biologic agents, that is, only 3.4% of patients treated with etanercept and 6% of patients treated with adalimumab therapy . On the other hand, we found that over 10% of patients showed definite regression of the MRI erosion scores.…”

Section: Discussioncontrasting

confidence: 40%

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Efficacy of abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands

et al. 2017

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Section: Discussioncontrasting

confidence: 40%

“…Second, there was no control group. Third, the observation period was limited in duration for ideal assessment of erosion repair …”

Section: Discussionmentioning

confidence: 99%

Efficacy of abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands

et al. 2017

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“…Radiographically, erosion healing in RA patients treated with disease-modifying anti-rheumatic drugs (especially biologic agents) occurs in 7-11% of patients [72,73] and in approximately 4% of affected joints [74]. MRI studies demonstrate decreased size in a minority (17%) of erosions in RA patients managed with these agents at 1 year, with partial repopulation of the affected bone by marrow fat at 6 years [75,76]. However, in individual patients, if there is any partial erosion repair, progression and development of new erosions typically occur simultaneously [73].…”

Section: Erosionsmentioning

confidence: 99%

MRI and ultrasound of the hands and wrists in rheumatoid arthritis. I. Imaging findings

Rubin

2019

Skeletal Radiol

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The management of patients with rheumatoid arthritis (RA) has rapidly evolved with the development of newer diseasemodifying drugs and the recognition that long-term damage can be mitigated by an earlier and more-informed use of these medications. Historically, radiographs were the mainstay of imaging in RA patients, but radiographic joint narrowing and erosions are late and insensitive findings in the disease. MRI (with intravenous contrast agent) and ultrasound (with power Doppler interrogation) of the hands and wrists are able to demonstrate erosions earlier and with greater sensitivity than radiographs. More importantly, these imaging studies also depict synovitis and active soft-tissue inflammation, which represents a precursor to structural damage. Additionally, MRI can show inflammation within the bones (osteitis), which is proving to be the most important prognosticator of an aggressive disease course. Part I of this review discusses the imaging techniques, pitfalls, definitions, and comparative studies of MRI and ultrasound for identifying and quantifying erosions, synovitis, and osteitis. Part II will demonstrate how these imaging findings influence the clinical management of RA patients throughout their disease course, from presentation through clinical remission.

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“…for the treatment of rheumatoid, juvenile rheumatoid and psoriatic arthritis [9,10]. Recent clinical data have indicated that Etanercept also has beneficial effects on preventing bone erosions in rheumatoid arthritis and psoriasis [11,12]. Given the emerging evidence that TNF-α plays a similar and central pathogenetic role in prosthetic loosening and rheumatoid arthritis, we proposed that Etanercept has the ability to inhibit wear debris induced osteolysis.…”

Section: Introductionmentioning

confidence: 99%

Etanercept Inhibits Pro-inflammatory Cytokines Expression in Titanium Particle-Stimulated Peritoneal Macrophages

Chen¹,

Zhan²,

Lü³

et al. 2015

Trop. J. Pharm Res

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Purpose: To investigate the inhibitory role of Etanercept in pro-inflammatory cytokines such as (34.79 ± 7.83 pg/mL, p > 0.05), 21.06 % at 100 ng/mL (28.98 ± 4.81 pg/mL, p < 0.01) and 29.83 % at 1000 ng/mL (25.76 ± 5.23 pg/ml, p < 0.001), and IL-6 release by 38.69 % at 10 ng/mL (256.8 ± 99.56 pg/mL, p < 0.01), by 42.13 % at 100 ng/mL (242.4 ± 33.26 pg/mL, p < 0.01) and 53.4 % at 1000 ng/ml (195.2 ± 48.82 pg/mL, p < 0.001). Conclusion: Etanercept has potent ability to prevent wear debris-induced osteolysis and may be valuable as a therapeutic agent for the treatment of prosthetic loosening in humans.

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Repair of erosions in patients with rheumatoid arthritis treated with etanercept: magnetic resonance imaging findings after 1 year of follow-up

Abstract: Etanercept combined with DMARDs stopped the progression of erosions, as measured by the RAMRIS, in 82.8% of our RA patients and occasional repair of bone erosions occurred after 1 year of treatment.

Cited by 9 publications

References 27 publications

Efficacy of abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands

Efficacy of abatacept in patients with rheumatoid arthritis, as assessed by magnetic resonance imaging of bilateral hands

MRI and ultrasound of the hands and wrists in rheumatoid arthritis. I. Imaging findings

Etanercept Inhibits Pro-inflammatory Cytokines Expression in Titanium Particle-Stimulated Peritoneal Macrophages

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