Repair of long intercalated rib defects using porous beta-tricalcium phosphate cylinders containing recombinant human bone morphogenetic protein-2 in dogs

Current trends and future perspectives of bone substitute materials – From space holders to innovative biomaterials

“…It belongs to the transforming growth factor super family (TGF-b), inducing growth and differentiation of stem cells into different specific tissue cells. Human rhBMP-2 is a very promising composite, with beta-TCP having osteogenicity and efficiency even for repairing large bone defects (Hoshino et al, 2006). The synthetic biodegradable polymer/ interconnected-porous calcium HA ceramics composite (IP-CHA) is an excellent combination carrier/scaffold delivery system for recombinant bone morphogenetic protein-2 (rhBMP-2), that strongly promotes the clinical effects of rhBMP-2 in bone tissue regeneration.…”

Incorporation of RANKL promotes osteoclast formation and osteoclast activity on β-TCP ceramics

“…However, pure calcium phosphate ceramics are not suitable to reconstruct large bone defects because these bone substitute materials are not replaced by authentic bone completely. Due to the brittleness of the material incomplete material turnover results in unstable union of the materialhost bone junction and compromises long-term mechanical stability [7][8][9]. Furthermore, the degradation process and the formation of new bone are not coordinated because calcium phosphate ceramics do not possess intrinsic triggers to initiate resorption and they do not provide signals to couple resorption to bone formation.…”

“…However, in large bone defects, the substitution of the material by authentic bone is incomplete [6,7]. Due to the brittleness of the material and unstable union of the material-host bone junction incomplete material turnover may compromise mechanical stability of the reconstructed bone [7][8][9]. Previously, osteoinductive growth factors such as the bone morphogenetic proteins (BMP) have been used to improve bone defect healing with calcium phosphate based biomaterials [10][11][12][13].…”

Repairing Defect and Preventing Collapse of Canine Femoral Head Using Titanium Implant Enhanced by Autogenous Bone Graft and rhBMP-2

“…Some of studies have confirmed the potential for growth and differentiation factors to effect more healing and filling of defects with biomechanically competent and viable bone [7,[27][28][29]. The enhancement of healing could shorten the period of restricted weight-bearing, ensure better compliance, and lead to more successful outcomes.…”