Repair of oronasal fistulas with human amniotic membrane in minipigs

Kesting, Marco; Loeffelbein, Denys J.; Classen, M; Slotta‐Huspenina, Julia; Hasler, Rafael Johannes; Jacobsen, Frank; Kreutzer, Kilian; Al-Benna, Sammy; Wolff, Klaus‐Dietrich; Steinstraesser, Lars

doi:10.1016/j.bjoms.2009.04.025

Cited by 37 publications

(51 citation statements)

References 25 publications

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“…Two of the three fistulas closed with the HAM were successful and offered a promise as a simple and effective technique for tension-free closure of such fistulas [8].…”

Section: Discussionmentioning

confidence: 93%

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Effectiveness of Human Amnion as a Graft Material in Lower Anterior Ridge Vestibuloplasty: A Clinical Study

Sharma

Maria

Kaur

2011

J. Maxillofac. Oral Surg.

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Objective The aim of this study is to evaluate the clinical use of amnion as a biodegradable graft material for lower anterior ridge vestibuloplasty. Study Design Ten patients who had been referred for preprosthetic surgery underwent mandibular anterior ridge vestibuloplasty using Clark's technique and amniotic membrane as a graft material. Preoperative vestibular depth was measured. Fresh amniotic membrane was placed in the surgical site and sutured with 4-0 vicryl. In all ten cases suction catheter stent was used and was secured in the depth of the vestibule by using 1-0 mersilk percutaneous sutures. Results Vestibular depths were measured using a divider and a scale. Post operative measurements were taken at the end of 10th day, 1st month and 3rd month. And an average gain of 4-6 mm in the depth of the labial vestibule was noted. Conclusion Amniotic membrane can be a favorable graft material for vestibuloplasty, promoting healing and preventing relapse. It is easily available and preserved and a cost effective material.

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“…Two of the three fistulas closed with the HAM were successful and offered a promise as a simple and effective technique for tension-free closure of such fistulas [8].…”

Section: Discussionmentioning

confidence: 93%

“…The probable mechanism of amnion's anti-adhesive characteristic is contact with healthy tissue that induces an arrest in tissue proliferation. In addition, the amniotic membrane transplant may also function as an anatomical barrier to fibrous tissue proliferation [8].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Human Amnion as a Graft Material in Lower Anterior Ridge Vestibuloplasty: A Clinical Study

Sharma

Maria

Kaur

2011

J. Maxillofac. Oral Surg.

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“…According to Fontenla et al to Schwanet al 6 , the use of AM began with De Rotth in 1940 in ophthalmology, the specialty in which AM is currently most heavily researched. Studies have described its application in varicose ulcers 7 , burns 8 , neovaginal reconstruction 9 , urinary bladder reconstruction 10 , nerve damage 11 , oral wounds 12 , skin trauma 13 , ocular injuries 14 , adhesion control, and peritoneal structure scarring 15 .…”

Section: Introductionmentioning

confidence: 99%

Amniotic membrane as a biological dressing in infected wound healing in rabbits

Duarte

Duval-Araujo

2014

Acta Cir. Bras.

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PURPOSE:To investigate amniotic membrane as a biological dressing in infected wound healing in rabbits. METHODS:The use of preserved amniotic membranes (AMs) was examined using 15 rabbits with experimentally induced wound infections on their backs. Healing was histologically evaluated during different phases including inflammation, granulation, epithelialization, and fibroplasia. The animals were distributed into three groups for histological study at seven, 14, 21, and 28 days postwound induction. Group A did not receive treatment: the wound was left exposed and dry; Group B received a daily exposure treatment with collagenase; and Group C received one AM, which also remained exposed. RESULTS:A marked reduction of the inflammatory phase was observed in Group C at 21 days, and the granulation phase of this healing increased at 14 days. Epithelialization was similar among the three groups, and fibroplasia was more pronounced in Group C at 14 days. Furthermore, gradual collagen organization also began for the animals in Group B at 14 days. CONCLUSION:The amniotic membrane did not significantly alter the inflammation, epithelialization, or fibroplasia phases but did increase angiogenesis up to Day 14 compared with the dry dressing and collagenase treatments.

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“…Fontenla et al 2 and del Campo et al 4 , report that in 1995, Kim and Tseng reintroduced the use of amniotic membrane in the treatment of ocular lesions, ophthalmology being the specialty where more research is made on the use of amniotic membrane today. There are other studies on its use for burns 5,6 , varicose ulcers 5,7 , neovagina reconstruction 5,8 , urinary bladder 5,9 , nerve damage 5,10 , mouth sores 5,11 , adhesions control and early healing of peritoneal lesions 5,12 , among others. The study of clinical use of amniotic membrane is of increasing importance due to its low antigenicity, antimicrobial activity, ability to decrease exudate and adhesions, to accelerate epithelization, reducing the local pain, actingas a substrate for tissue growth, among many other actions 5 .…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats

Barbuto

Araújo

Bonomi³

et al. 2015

Rev. Col. Bras. Cir.

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Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene mesh in rats mesh in rats mesh in rats mesh in rats mesh in rats Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos Objective Objective: to evaluate the efficacy of the amniotic membrane used with polypropylene mesh against the formation of adhesions and its influence on healing. Methods Methods Methods Methods Methods: twenty five female Wistar rats were anesthetized for creating a parietal defect in the anterior abdominal wall. Its correction was made with polypropylene mesh alone and associated with amniotic membrane. In the control group (n=11), the screen was inserted alone. In group A (n=7) we interposed the amniotic membrane between the screen and the abdominal wall. In group B, the amniotic membrane was placed on the mesh, covering it. After seven days, the animals were euthanized for macroscopic and microscopic evaluation of healing. Results Results ResultsResults Results: adhesions were observed in all animals except one in the control group. Severe inflammation was observed in all animals in groups A and B and in three of the control group, with significant difference between them (A and B with p=0.01). Pronounced angiogenic activity was noted in one animal in the control group, six in group A and four in group B, with a significant difference between the control group and group A (p=0.002) and group B (p=0.05). The scar collagen was predominantly mature, except in five animals of the control group, with significant difference between the control group and group A (p=0.05) and group B (p=0.05). Conclusion Conclusion Conclusion Conclusion Conclusion: The amniotic membrane did not alter the formation of adhesions in the first postoperative week. There were also pronounced inflammation, high angiogenic activit...

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Repair of oronasal fistulas with human amniotic membrane in minipigs

Cited by 37 publications

References 25 publications

Effectiveness of Human Amnion as a Graft Material in Lower Anterior Ridge Vestibuloplasty: A Clinical Study

Effectiveness of Human Amnion as a Graft Material in Lower Anterior Ridge Vestibuloplasty: A Clinical Study

Amniotic membrane as a biological dressing in infected wound healing in rabbits

Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats

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