Repair of Radiation Damage to Rat Thyroid Cells<i>in Vivo</i>: A Highly-differentiated System

Malone, J. F.; Hooper, L. A.; Orr, J. S.; Greig, W. R.

doi:10.1080/09553007214550581

Cited by 13 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 and 4 is the degree to which they correspond with previously reported values obtained in vivo (Table I) using a method which in principle measured a different endpoint. The in vivo data presented by Greig et al (1970) and Malone et al (1972;1974a) were referred to as cell-survival measurements, but are not directly comparable with those reported here. In essence, the in vivo data measure the net increase in gland weight after maximal goitrogenic stimulation.…”

Section: Discussionmentioning

confidence: 85%

The radiobiological response of the thyroid. Part II: Response of sheep thyroid cell in vitro to single doses of X rays

O’Connor¹,

Malone²,

Moriarty³

et al. 1980

BJR

View full text Add to dashboard Cite

The response of sheep thyroid cells in culture to single doses of X or gamma rays is described. In the absence of cellular proliferation the cells are unusually radioresistant, showing little sign of interphase death at doses up to 9 krad. The follicular morphology characteristic of thyroid cells in vivo is also very radioresistant. Iodide trapping is reduced to 50% of the control value by doses of the order of 2 krad. When proliferation is induced the cells may be assayed for postirradiation survival using a clonogenic endpoint. The survival curves are sigmoid with a Do of 410 rad and a very low extrapolation number.

show abstract

Section: Discussionmentioning

confidence: 85%

The radiobiological response of the thyroid. Part II: Response of sheep thyroid cell in vitro to single doses of X rays

O’Connor¹,

Malone²,

Moriarty³

et al. 1980

BJR

View full text Add to dashboard Cite

show abstract

“…Split-dose recovery has been described in several cell systems and is at least partly due to the repair of single and double stranded DNA breaks (Elkind and Sutton 1959; Elkind et al 1967; Hall 2000; Utsumi and Elkine 2001). Other hypotheses such as repair pool replenishment have been suggested (Orr et al 1966a; Orr et al 1966b; Malone et al 1971; Laurie et al 1972; Malone et al 1972; Orr 1984). Inducible defenses such as those seen in classical adaptive response experiments have been suggested to be involved in split dose recovery as well (Seymour and Mothersill 1989; Mothersill and Seymour 1993).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Non-Linear Adaptive Responses and Split Dose Recovery Induced by Ionizing Radiation in Three Human Epithelial Derived Cell Lines

Ryan¹,

Seymour²,

Mothersill³

2009

Dose-Response

View full text Add to dashboard Cite

Two almost completely exclusive fields in radiobiology deal with splitting doses of radiation and comparing the effect to a similar total dose given in one exposure. In radiotherapy, dose "fractionation" is used to "spare" normal tissue and in the low dose field, the adaptive response is well documented as a phenomenon where a small "priming" dose administered before the larger "challenge" dose reduces the effect of the large dose. There have been very few studies where these fields overlap, thus it is not possible to ascertain whether common or distinct mechanisms underlie both phenomena but this is certainly an interesting question and relevant to our understanding of high and low dose radiobiology. This paper presents data for three human cell lines with varying p53 status and radiation responses, treated at a range of times between first and second dose and for 3 different first doses (0.1, 0.5 and 2Gy). The data show that time between doses is critical. Protective (adaptive) effects were seen in each cell line but most prominently in the malignant HT 29 cell line. Surprisingly none of the cell lines showed pronounced split dose recovery. This suggests different mechanisms may underlie the two phenomena.

show abstract

Effects of Ionizing Radiation on Mammalian Cells

Little

Williams

1977

Comprehensive Physiology

View full text Add to dashboard Cite

The sections in this article are: Physical and Chemical Events Development of Radiation Injury The Target Theory Direct and Indirect Effects, Radiation Chemistry Effects on Cell Division Division Delay Mitotic Inhibition (Reproductive Failure) Radiation Sensitivity in Different Phases of the Life Cycle Chromosomal Damage Interphase Death Nonlethal Heritable Changes Biological Variation in Radiation Sensitivity Mechanisms Modification of Radiation Effects Physical Factors Chemical Radiation Protection and Sensitization Oxygen Effect Intracellular Recovery Processes Repair of Potentially Lethal Damage Repair of Sublethal Damage (Split‐Dose Recovery) Molecular Repair Processes Damage Observed in DNA Cellular Repair Systems for DNA Damage Repair Activities in Mammalian Cells Correlation of DNA Repair with Biological Effects Concluding Remarks Addendum

show abstract

Repair of Radiation Damage to Rat Thyroid Cellsin Vivo: A Highly-differentiated System

Cited by 13 publications

References 10 publications

The radiobiological response of the thyroid. Part II: Response of sheep thyroid cell in vitro to single doses of X rays

The radiobiological response of the thyroid. Part II: Response of sheep thyroid cell in vitro to single doses of X rays

Investigation of Non-Linear Adaptive Responses and Split Dose Recovery Induced by Ionizing Radiation in Three Human Epithelial Derived Cell Lines

Effects of Ionizing Radiation on Mammalian Cells

Contact Info

Product

Resources

About