Repair of subtotal tympanic membrane perforations with Seprafilm^®

Abstract

These results suggest that Seprafilm may be a possible first choice (before the decision to operate) in subtotal perforations, considering its easy application and patient follow-up.

Orbital Wall Fracture Repair Using Seprafilm

“…Its use in other surgical arenas has expanded, both clinically and experimentally, including prevention of postoperative pelvic/gynecological and thoracic/ pericardial adhesions, prevention of peritendinous adhesions after flexor tendon injury, prevention of poststrabismus surgery adhesions, and in the repair of subtotal tympanic membrane perforations and retinal breaks. [2][3][4][5][6][7][8][9][10][11][12][13] Seprafilm is composed of hyaluronic acid and carboxymethylcelluose that have been modified to increase their persistence in the body. Hyaluronate, a glycosoaminoglycan made of repeating disaccharide units of glucuronic acid and N-acetylglucosamine, is a normal constituent of extracellular matrix, connective tissue, synovial fluids, umbilical cord, and vitreous humor.…”

“…14 Clinical and experimental studies suggest that Seprafilm is safe and noninflammatory. [2][3][4][5][6][7][8][9][10][11][12][13] Bülbüller et al 17 demonstrated that Seprafilm prevented postoperative adhesions without affecting injury recovery. Otake et al 18 showed that polymorphonuclear neutrophil function is not altered by Seprafilm.…”

“…[2][3][4][5][6][7][8][9][10] It has also been studied in the repair of subtotal tympanic membrane perforation and retinal breaks. 11,12 In the ophthalmic literature, Seprafilm has been shown to significantly reduce postoperative Accepted for publication November 10, 2008 . This 24-year-old man also had repair of a nasoethmoidal fracture through a modified Lynch incision; he was excluded from our study, but he had successful recovery with full ocular motility postoperatively.…”

Biodegradable Films in Trauma and Orthopedic Surgery

“…Also, one study reported Seprafilm to be superior to Goretex ® in the prevention of peridural fibrosis in an animal rabbit model [34]. Other applications were adhesion prophylaxis in congenital cardiac surgery [35] and the repair of subtotal tympanic membrane perforations [36] in a study conducted in rats.…”

Development of water‐insoluble chitosan patch scaffold to repair traumatic tympanic membrane perforations

“…11 Several scaffolds that could stimulate tympanic regeneration, guide eardrum growing, or replace the perforated defects have not been introduced until recently. The biocompatible scaffolds such as hydrogels, 12 collagen, 13 Seprafilm 1 (hyaluronic acid and carboxymethylcellulose), 14 or calcium alginate 15 were tested for closure of TM perforations. However, most of these studies lacked analysis regarding the biomechanical properties of new materials from a biomaterial perspective and were limited to small animal studies from a clinical perspective.…”