2020
DOI: 10.1016/j.jmb.2019.08.010
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Repair or Lysophagy: Dealing with Damaged Lysosomes

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Cited by 144 publications
(127 citation statements)
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“…Lysosomal membrane permeabilization (LMP) or lysosomal complete rupture is the common form of lysosomal damage, and it is a potential hazard to cell fate and function 73 . Maintaining lysosomal structural integrity and functional homeostasis through LQC favors the physiological functions of cells.…”
Section: Lysosomal Quality Controlmentioning
confidence: 99%
See 1 more Smart Citation
“…Lysosomal membrane permeabilization (LMP) or lysosomal complete rupture is the common form of lysosomal damage, and it is a potential hazard to cell fate and function 73 . Maintaining lysosomal structural integrity and functional homeostasis through LQC favors the physiological functions of cells.…”
Section: Lysosomal Quality Controlmentioning
confidence: 99%
“…When LMP occurs, endogenous protective mechanisms are initiated to repair membrane damage, and prevent the release of lumenal hydrolases 73 . Previous studies documented the protective effects of Hsp70 for maintaining lysosomal integrity, showing that it can stabilize lysosomal membrane by binding to lipid bisphosphonates and enhancing the activity of acidic sphingolipase 78,79 .…”
Section: Lysosomal Repairmentioning
confidence: 99%
“…The damage of intracellular membranes triggered by oxidative stress, internalised extracellular agents and intracellular pathogens is relevant to inflammation and neurodegeneration (Lawrence & Zoncu, ; Papadopoulos et al , ). To protect themselves from the potential detrimental consequences, mammalian cells have several mechanisms to recognise and restrict the damage of endomembranes.…”
Section: Introductionmentioning
confidence: 99%
“…Subsequently, dephosphorylation of the master regulator of lysosomal biogenesis transcription factor EB (TFEB) occurs, causing its translocation to the nucleus, transcriptional activation, and de novo lysosomal biogenesis (30). Concurrently, the damaged lysosomes are removed by lysophagy (36). Thus, the present results indicated that after AZM blocked the autophagic flux, the feedback loop described below may explain the resulting increase in impaired lysosome numbers, leading to LMP and necrosis: LPZ and AZM induced lysosomal damage → lysosomal biogenesis by TFEB → lysosomal accumulation due to AZM blocking lysophagy → a considerable number of lysosomes with LMP → pronounced LMP-mediated necrosis induction.…”
Section: Discussionmentioning
confidence: 52%