Repairing injured peripheral nerves: Bridging the gap

Deumens, Ronald; Bozkurt, Ahmet; Meek, Marcel F.; Marcus, Marco A. E.; Joosten, Elbert A.J.; Weis, Joachim; Brook, Gary

doi:10.1016/j.pneurobio.2010.10.002

Cited by 445 publications

(420 citation statements)

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“…Peripheral nerve injuries (PNIs) are a major cause of morbidity, especially as in most cases the upper limbs are affected (Deumens et al., 2010; Kouyoumdjian, 2006). In 10.2% of all hand injuries, a peripheral nerve reconstruction is required, whereas in two third of the cases, the digital nerves are damaged (Renner, Cserkuti, & Hankiss, 2004).…”

Section: Introductionmentioning

confidence: 99%

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

2017

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IntroductionThe rat median nerve injury and repair model gets increasingly important for research on novel bioartificial nerve grafts. It allows follow‐up evaluation of the recovery of the forepaw functional ability with several sensitive techniques. The reflex‐based grasping test, the skilled forelimb reaching staircase test, as well as electrodiagnostic recordings have been described useful in this context. Currently, no standard values exist, however, for comparison or comprehensive correlation of results obtained in each of the three methods after nerve gap repair in adult rats.MethodsHere, we bilaterally reconstructed 7‐mm median nerve gaps with autologous nerve grafts (ANG) or autologous muscle‐in‐vein grafts (MVG), respectively. During 8 and 12 weeks of observation, functional recovery of each paw was separately monitored using the grasping test (weekly), the staircase test, and noninvasive electrophysiological recordings from the thenar muscles (both every 4 weeks). Evaluation was completed by histomorphometrical analyses at 8 and 12 weeks postsurgery.ResultsThe comprehensive evaluation detected a significant difference in the recovery of forepaw functional motor ability between the ANG and MVG groups. The correlation between the different functional tests evaluated precisely displayed the recovery of distinct levels of forepaw functional ability over time.ConclusionThus, this multimodal evaluation model represents a valuable preclinical model for peripheral nerve reconstruction approaches.

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Section: Introductionmentioning

confidence: 99%

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

2017

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“…Short gaps (few mm), can be repaired by direct suture of the proximal and the distal stumps with end-to-end coaptation and epineural suturing. The most common treatment for longer nerve gaps is surgical repair using autologous nerve grafts (autografts) (Deumens et al, 2010;Kandenwein, Kretschmer, Engelhardt, Richter, & Antoniadis, 2005). Autografts have shown high efficacy in inducing nerve regeneration because they provide to the regenerating axons a natural guidance channel with SC surrounded by their basal lamina, allowing appropriate alignment of outgrowing axons (Deumens et al, 2010).…”

Section: Nrg1 To Promote Nerve Repair Peripheral Nerve Injury and Repairmentioning

confidence: 99%

“…The most common treatment for longer nerve gaps is surgical repair using autologous nerve grafts (autografts) (Deumens et al, 2010;Kandenwein, Kretschmer, Engelhardt, Richter, & Antoniadis, 2005). Autografts have shown high efficacy in inducing nerve regeneration because they provide to the regenerating axons a natural guidance channel with SC surrounded by their basal lamina, allowing appropriate alignment of outgrowing axons (Deumens et al, 2010). However, there are some drawbacks in using autografts: donor site morbidity and sensory loss, scarring, neuroma formation and limited length of available graft material encouraging the search of alternatives for nerve gap reconstruction.…”

Section: Nrg1 To Promote Nerve Repair Peripheral Nerve Injury and Repairmentioning

confidence: 99%

“…However, there are some drawbacks in using autografts: donor site morbidity and sensory loss, scarring, neuroma formation and limited length of available graft material encouraging the search of alternatives for nerve gap reconstruction. On the other hand, current techniques and artificial nerve conduit devices available to support regeneration across large lesion gaps have limited success (Deumens et al, 2010;Steed, Mukhatyar, Valmikinathan, & Bellamkonda, 2011). Allografts have been used, but immunosuppression is required and this technique results in poor success rates (Mackinnon & Dellon, 1990).…”

Section: Nrg1 To Promote Nerve Repair Peripheral Nerve Injury and Repairmentioning

confidence: 99%

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Neuregulin 1 Role in Schwann Cell Regulation and Potential Applications to Promote Peripheral Nerve Regeneration

Gambarotta

Fregnan

Gnavi

et al. 2013

International Review of Neurobiology

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Neuregulin 1 (NRG1) is a multifunctional and versatile protein: its numerous isoforms can signal in a paracrine, autocrine or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury. Accordingly, the use of NRG1 in vivo has already yielded encouraging results.The aim of this review is to focus on the role played by the different NRG1 isoforms during peripheral nerve regeneration and remyelination and to identify good candidates to be used for the development of tissue engineered medical devices delivering NRG1, with the final goal to promote better nerve repair.

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“…Peripheral nerve damage due to trauma, tumour surgery or dis-ease represents a relevant social and economical problem [1][2][3]. Unlike the central nervous system, the peripheral nerve has a strong potential for regeneration [4].…”

Section: Introductionmentioning

confidence: 99%

Neuregulin1 administration increases axonal elongation in dissociated primary sensory neuron cultures

Audisio

Mantovani

Raimondo

et al. 2012

Experimental Cell Research

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Neuregulin1 is a family of growth and differentiation factors involved in various functions of both peripheral and central nervous system including the regenerative processes that underlie regeneration of damaged peripheral nerves. In the present study we tested in vitro the effect of Neuregulin1 administration on dissociated rat dorsal root ganglion (DRG). Activity of neuregulin1 was compared to the activity of nerve growth factor in the same in vitro experimental model. Results showed that neurite outgrowth is enhanced by the addition of both neuregulin1 and nerve growth factor to the culture medium. While neuregulin1 was responsible for the growth of longer neurites, DRG neurons incubated with nerve growth factor showed shorter and more branched axons. Using enzyme-linked immunosorbent assay we also showed that the release of nerve growth factor, but not of brain derived neurotrophic factor is improved in DRG neuron treated with neuregulin1. On the other hand, the assay with growth factor blocking antibody, showed that effects exerted by neuregulin1 on neurite outgrowth is only partially due to the release of nerve growth factor. Taken together the results of this study provide a better understanding on the role of neuregulin1 in sensory neurons.

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Repairing injured peripheral nerves: Bridging the gap

Cited by 445 publications

References 272 publications

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

Neuregulin 1 Role in Schwann Cell Regulation and Potential Applications to Promote Peripheral Nerve Regeneration

Neuregulin1 administration increases axonal elongation in dissociated primary sensory neuron cultures

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