Reparative reactions of the skeletal muscles in early aging OXYS rats with toxic metabolic injuries caused by bupivacaine

Abstract

Comparative analysis of reparative reactions in the anterior tibialis muscles of OXYS and Wistar rats after intramuscular injections of bupivacaine was carried out for eva, luating the regeneratory potential of skeletal muscles under conditions of chronic disorders of oxidative metabolism. Lumpy degradation of lesion foci and mononuclear cell infiltration predominated on day 1; after 3 days myoblast proliferation and fusion processes were maximally pronounced; after 7 days maturing myotubules created groups of fibers with central nuclei. At the ultrastructural level, regeneration of the muscle fibers was associated with signs of activation of their nuclei and of satellite cell nuclei. Lesser (in comparison with the control) mean cross-section areas of the muscle fibers on day 14 after the start of the experiment indicated that the regeneration processes were not completed by this term. The proliferative potential of myogenic precursor cells was retained in hereditary dysfunction of mitochondria in OXYS rats.

miR-205 Regulates the Fusion of Porcine Myoblast by Targeting the Myomaker Gene

“…Bupivacaine is considered one of the most toxic drugs in the skeletal muscle [ 30 , 31 , 32 ], and the Burn team first discovered that local anesthetics cause changes in muscle histomorphology [ 33 ]. Gergin et al demonstrated that 0.5% bupivacaine causes the most serious damage to muscle tissue [ 34 ].…”