2018
DOI: 10.1186/s12871-018-0509-5
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Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

Abstract: BackgroundThere is increasing interest in whether anesthetic agents affect the risk or progression of Alzheimer’s disease (AD). To mitigate many of the methodological issues encountered in human retrospective cohort studies we have used a transgenic model of AD to investigate the effect of propofol on AD pathology.MethodsSix month-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic AD mice and control mice were exposed to 3 doses of propofol (200 mg/kg) or vehicle, delivered at monthly intervals.Re… Show more

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Cited by 8 publications
(3 citation statements)
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“…Propofol is another widely used general anesthesia that can induce GABAergic activities in the CNS [ 52 ]. Previous reports showed that minimal impact on behavior and pathological changes were observed in Alzheimer’s disease mice with propofol treatment [ 53 , 54 ]. These findings, together with our data, suggest that propofol may be used as an alternative of sevoflurane for patients with pre-existing pathological background.…”
Section: Discussionmentioning
confidence: 99%
“…Propofol is another widely used general anesthesia that can induce GABAergic activities in the CNS [ 52 ]. Previous reports showed that minimal impact on behavior and pathological changes were observed in Alzheimer’s disease mice with propofol treatment [ 53 , 54 ]. These findings, together with our data, suggest that propofol may be used as an alternative of sevoflurane for patients with pre-existing pathological background.…”
Section: Discussionmentioning
confidence: 99%
“…As is well known, amyloid plaques formation within the brain caused by the aggregation of β-amyloid (Aβ) polypeptides is one of the pathological hallmarks of AD. Considerable literature has demonstrated that APP/PS1 mice just begin to show occasional Aβ deposits at 6 month of age [37,38], with severe astrocytosis developing in parallel with plaque deposition [39]. At the age of 9 month, abundant plaques appear in the hippocampus and cortex of the transgenic mice, and more neuronal loss is observed adjacent to plaques than in more distal areas [40].…”
Section: Discussionmentioning
confidence: 99%
“…This is so alternative anesthetics may be used for patients with AD neuropathological signs. In this context, propofol is a general intravenous anesthetic drug which has proven to have a minimal impact on behavior and pathological changes in AD mouse models [47,48].…”
Section: Anesthetic Neurotoxicitymentioning
confidence: 99%