Repeatability of automated vessel density measurements using optical coherence tomography angiography

Al-Sheikh, Mayss; Tepelus, Tudor; Nazikyan, Tigran; Sadda, Srinivas R.

doi:10.1136/bjophthalmol-2016-308764

Cited by 144 publications

(144 citation statements)

References 26 publications

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“…Overall, we observed that the repeatability of vessel density measurements was higher for the superficial plexus than the deep plexus, similar to previous work,21 and is likely the result of higher resolution of the superficial plexus compared with the deep plexus on the instrument used for this study. We also noted the presence of significant variation in vessel density in our study population, which was comparable to that reported previously, although our study included a group of patients at older age compared with previous studies 23.…”

Section: Discussionsupporting

confidence: 88%

Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Fenner

Tan

et al. 2017

Br J Ophthalmol

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Section: Discussionsupporting

confidence: 88%

Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Fenner

Tan

et al. 2017

Br J Ophthalmol

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“…Macular quantitative parameters vary across different instruments and techniques (i.e., manual versus automatic assessment); however, several studies demonstrated that they have a good inter-and intraoperator reliability in case of same machine, acquisition and postprocessing protocols. [7][8][9]11,12,23 Measurement at the superficial plexus is highly reliable, while manual demarcation at the deep plexus may be not easy due to less definite contours.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported that these parameters have high intraand interoperator reproducibility both in eyes with and without retinal diseases, for the same scan type and for the same machine. [7][8][9][10][11][12][13] In a study by Dong and coworkers, 14 a good agreement between 3 3 3-and 6 3 6-mm angiocubes was found for choriocapillary vessel density and for FAZ area at all retina vasculatures; conversely, reliability for retinal vessel density was weak. However, scan interchangeability has been only tested for small angiocubes and it remains uncertain for wider size scans (e.g., 12 3 12 mm).…”

mentioning

confidence: 99%

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Rabiolo

Gelormini

Marchese

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the macular quantitative parameters interchangeability of three different optical coherence tomography angiography (OCT-A) angiocubes (i.e., 3 3 3, 6 3 6, and 12 3 12 mm) on healthy subjects and patients affected by diabetic retinopathy (DR) and to assess the interrater reliability of such indices across the different scan protocols. METHODS.Retrospective study involving 20 eyes of healthy subjects and 20 eyes with DR. All eyes underwent swept-source OCT-A with 3 3 3-, 6 3 6-, and 12 3 12-mm angiocubes centered on the fovea. Foveal avascular zone (FAZ) area and vessel density on 3 3 3-, 6 3 6-, and 12 3 12-mm macular scans were calculated by three independent operators at all retina, superficial, deep, and choriocapillary vascular layers. Interchangeability and interrater reliabilities were estimated using intraclass correlation coefficient (ICC).RESULTS. Interscan reproducibility of FAZ area was very strong (ICC > 0.85) at every plexus. On the contrary, vessel density values significantly varied across different scan sizes (ICC < 0.51). Intrascan interrater reliability was high for all retina and superficial FAZ areas, while it was satisfactory at deep capillary plexus only for 3 3 3-mm scan.CONCLUSIONS. FAZ area at all plexuses is a robust parameter even if calculated on angiocubes with different size. However, interrater reliability is higher when measured in smaller scans. Conversely, vessel density results depend on the size of angiocube, although their interrater reliability is extremely high. Studies involving OCT-A should take into consideration that scan size may influence macular perfusion parameters and interrater reliability.

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“…The image information signal is proportional to the blood flux and can be used to reflect the microcirculation. Split-spectrum amplitude decorrelation angiography algorithm has the advantage of reducing the interference signals and eye motions and is used to measure the avascular zone and superficial retinal vessel density in the macular zone with higher reliability [10, 11]. However, the reliability of vessel density measurement in the peripapillary retina is not clear.…”

Section: Introductionmentioning

confidence: 99%

Reliability of Vessel Density Measurements in the Peripapillary Retina and Correlation with Retinal Nerve Fiber Layer Thickness in Healthy Subjects Using Optical Coherence Tomography Angiography

She

Guo

et al. 2018

Ophthalmologica

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Purpose: To evaluate the reliability of vessel density measurements in the peripapillary retina using optical coherence tomography angiography (OCT-A) and to analyze the correlation with retinal nerve fiber layer (RNFL) thickness in healthy subjects. Method: Thirty-five healthy volunteers were recruited in the study. The optic disc region was scanned three times with spectral-domain OCT (SD-OCT) and split-spectrum amplitude decorrelation angiography by two skilled examiners. Vessel density of the peripapillary retina was automatically calculated by the software RTVue-XR (version 2015.1.1.98). The RNFL thickness on the optic nerve head was measured by SD-OCT. The coefficient of variation (CV), coefficient of repeatability, and intraclass correlation coefficients (ICC) were calculated for intraobserver repeatability. The Bland-Altman analysis was used to determine interobserver reproducibility. Correlations between peripapillary retinal vessel density and RNFL thickness were analyzed using a multivariable linear regression. Results: The mean age of the volunteers was 47.0 ± 29.7 years. The intraobserver repeatability in different sectors of the peripapillary retina was good with a high coefficient of repeatability, low CV (< 0.2%), and high ICC (0.847–0.952). The interobserver reproducibility was also good in different sectors, but should be interpreted with caution due to the difference bias caused by different observers in some quadrants. There was a significant positive correlation between vessel density and RNFL thickness; optic disc rim area and disc area were negatively related to vessel density (p = 0.008 and p = 0.001, respectively). Conclusion: Vessel density measurements showed good repeatability and reproducibility by OCT-A in the peripapillary retina, the vessel density was positively related to RNFL thickness and negatively related to optic disc area and rim area.

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Repeatability of automated vessel density measurements using optical coherence tomography angiography

Cited by 144 publications

References 26 publications

Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Reliability of Vessel Density Measurements in the Peripapillary Retina and Correlation with Retinal Nerve Fiber Layer Thickness in Healthy Subjects Using Optical Coherence Tomography Angiography

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