Repeated “all out” interval exercise causes an increase in serum hepcidin concentration in both trained and untrained men

Antosiewicz, Jędrzej; Kaczor, Jan Jacek; Kasprowicz, Katarzyna; Laskowski, Radosław; Kujach, Sylwester; Łuszczyk, Marcin; Radzimiński, Łukasz; Ziemann, Ewa

doi:10.1016/j.cellimm.2013.06.006

Cited by 27 publications

(37 citation statements)

References 33 publications

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“…We speculate that although our data of IL-6 and TNF-α levels did not change significantly, IL-10 levels increased to deal with some type of persistent inflammatory status, and/or to inhibit exacerbated catabolic stimuli, such as glycogenolysis and lipolysis pathways. In addition, Antosiewicz et al (2013) have demonstrated that highintensity interval exercise (three Wingate bouts) promotes increases in IL-6 and IL-10 1 h post-exercise. However, more studies are necessary to better understand the mechanisms involved in HIITs.…”

Section: Discussionmentioning

confidence: 98%

Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise

et al. 2015

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Section: Discussionmentioning

confidence: 98%

Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise

et al. 2015

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“…Recently, we demonstrated that regular training reduced body iron stores in the elderly [10]. Moreover, highly trained young men are characterised by lower body iron stores compared to untrained young men [14]. Why regular training reduces body iron stores is not precisely understood; however, an increase in blood hepcidin may be an important cause.…”

Section: Discussionmentioning

confidence: 99%

“…Why regular training reduces body iron stores is not precisely understood; however, an increase in blood hepcidin may be an important cause. A single exercise session can lead to an increase in blood hepcidin, [14, 22] which can lead to lower intestinal iron absorption because it blocks ferroportin, a protein that exports iron from enterocytes into blood [15]. …”

Section: Discussionmentioning

confidence: 99%

“…Regular exercise reduces body iron stores; therefore, the lack of exercise may be responsible for body iron accumulation [10, 13]. The effect of exercise on iron metabolism may be mediated by an increase in the hepcidin concentration [14]. Hepcidin is a 25 aa peptide that inhibits intestinal iron absorption or its release from storage tissues, such as the liver and other organs [15].…”

Section: Introductionmentioning

confidence: 99%

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Simple sugar supplementation abrogates exercise-induced increase in hepcidin in young men

Tomczyk

Kortas

Flis

et al. 2017

Journal of the International Society of Sports Nutrition

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BackgroundAt present many young people experience too much body iron accumulation. The reason of this phenomenon is not clear. There is accumulating evidences that not proper diet and lack of exercise could be a main contributing factors. This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism.MethodsA group of physically active young men completed an incremental exercise test before and after a 3-day diet supplemented with fructose (4 g/kg BM) or glucose (4 g/kg BM). After a 1-week break, they crossed over to the alternate mode for the subsequent 3-days period. Venous blood samples were collected before and after 1 h exercise and were analysed for serum hepcidin, IL-6, CRP, iron, and ferritin. The physiological response to exercise was also determined.ResultsThe concentration of hepcidin increased 1 h after exercise for the baseline test (p < 0.05), whereas no changes in hepcidin were observed in men whose diet was supplemented with fructose or glucose. Blood IL-6 increased significantly after exercise only in subjects supplemented with fructose. Changes in hepcidin did not correlate with shifts in serum IL-6.ConclusionsThese data suggest that protective effects of exercise on excess iron accumulation in human body which is mediated by hepcidin can be abrogated by high sugar consumption which is typical for contemporary people.

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“…Clinical research demonstrated the peak hepcidin level to occur 3 h following the IL-6 peak rise [12]. The relationship between hepcidin and IL-6 was confirmed, investigating the response to a single dose of exercise: endurance [13] as well as interval training [14]. In addition, Roecker and co-workers observed a considerable increase in hepcidin level 24 h after a 42.2-km marathon run in female athletes [15].…”

Section: Introductionmentioning

confidence: 99%

The effect of the competitive season in professional basketball on inflammation and iron metabolism

et al. 2016

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Following acute physical activity, blood hepcidin concentration appears to increase in response to exercise-induced inflammation, but the long-term impact of exercise on hepcidin remains unclear. Here we investigated changes in hepcidin and the inflammation marker interleukin-6 to evaluate professional basketball players’ response to a season of training and games. The analysis also included vitamin D (25(OH)D3) assessment, owing to its anti-inflammatory effects. Blood samples were collected for 14 players and 10 control non-athletes prior to and after the 8-month competitive season. Athletes’ performance was assessed with the NBA efficiency score. At the baseline hepcidin correlated with blood ferritin (r = 0.61; 90% CL ±0.31), but at the end of the season this correlation was absent. Compared with the control subjects, athletes experienced clear large increases in hepcidin (50%; 90% CI 15-96%) and interleukin-6 (77%; 90% CI 35-131%) and a clear small decrease in vitamin D (-12%; 90% CI -20 to -3%) at the season completion. Correlations between change scores of these variables were unclear (r = -0.21 to 0.24, 90% CL ±0.5), but their uncertainty generally excluded strong relationships. Athletes were hence concluded to have experienced acute inflammation at the beginning but chronic inflammation at the end of the competitive season. At the same time, the moderate correlation between changes in vitamin D and players’ performance (r = 0.43) was suggestive of its beneficial influence. Maintaining the appropriative concentration of vitamin D is thus necessary for basketball players’ performance and efficiency. The assessment of hepcidin has proven to be useful in diagnosing inflammation in response to chronic exercise.

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Repeated “all out” interval exercise causes an increase in serum hepcidin concentration in both trained and untrained men

Cited by 27 publications

References 33 publications

Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise

Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise

Simple sugar supplementation abrogates exercise-induced increase in hepcidin in young men

The effect of the competitive season in professional basketball on inflammation and iron metabolism

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