2009
DOI: 10.1016/j.brainres.2009.06.042
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Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain

Abstract: Repeated exposure to sub-lethal insults has been reported to result in neuroprotection against a subsequent deleterious insult. The purpose of this study was to evaluate whether repeated exposure (preconditioning) to a non-5-HT depleting dose of MDMA in adult rats provides neuroprotection against subsequent MDMA induced 5-HT depletion. Treatment of rats with MDMA (10 mg/kg, ip every 2 hrs for 4 injections) resulted in a 50-65% depletion of 5-HT in the striatum, hippocampus and cortex, and these depletions were… Show more

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Cited by 28 publications
(41 citation statements)
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“…Single-time-point comparisons did not show any significant difference between MDMA-treated rats previously treated with sildenafil or saline. These data are in agreement with a recent report showing no difference in the hyperthermic response to a 5-HT-depleting regimen of MDMA in rats that had received saline or a preconditioning MDMA treatment 24 hr earlier (Bhide et al, 2009). …”
Section: Effect Of Sildenafil On Mdma-induced Hyperthermia and 5-ht Dsupporting
confidence: 93%
See 1 more Smart Citation
“…Single-time-point comparisons did not show any significant difference between MDMA-treated rats previously treated with sildenafil or saline. These data are in agreement with a recent report showing no difference in the hyperthermic response to a 5-HT-depleting regimen of MDMA in rats that had received saline or a preconditioning MDMA treatment 24 hr earlier (Bhide et al, 2009). …”
Section: Effect Of Sildenafil On Mdma-induced Hyperthermia and 5-ht Dsupporting
confidence: 93%
“…Minoxidil afforded protection against MDMA-induced 5-HT depletion by a similar mechanism (Goñi-Allo et al, 2008c). Not only acute but also delayed chemical preconditioning has been shown to protect the rat brain 5-HT neurotransmitter system from MDMA (Piper et al, 2006(Piper et al, , 2010Bhide et al, 2009). In this regard, 3-nitropropionic acid given 24 hr before a toxic MDMA treatment completely prevented 5-HT depletions by a mechanism involving NO production (Puerta et al, 2010c).…”
Section: Discussionmentioning
confidence: 90%
“…In contrast, a more diffuse band at approximately 63-68 kD (which has the expected regional brain distribution of the SERT, was markedly reduced after 5,7-DHT treatment and absent in SERT-KO animals) was decreased after MDMA administration (Xie et al, 2006), indicating that the SERT protein (like other 5-HT neuronal markers) is decreased after MDMA exposure. Recently, these results have been confirmed by others (Bhide et al, 2009;Cunningham et al, 2009;Biezonski and Meyer, 2010).…”
Section: Serotonin Neurotoxicitysupporting
confidence: 85%
“…However, it should be kept in mind that the measures likely mirror intensity of serotonergic innervations (Schaefer et al, 2008), but not functional activity of neurotransmission. Nevertheless, the range of 5HT content in the homogenized brain is 1 to 2 nmol/g (Baumann et al, 2008a;Bhide et al, 2009;Grahame-Smith et al, 1974;Malberg et al, 1998). Moreover, raphe nuclei have relatively higher contents than other regions (Adell et al, 1991b).…”
Section: Introductionmentioning
confidence: 93%
“…This is mainly because MDMA at high doses could cause a reduction in 5HT content in the brain and possibly axonal degeneration (Bhide et al, 2009;Malberg et al, 1998). In fact, there is no evidence indicating that clinically relevant doses of MDMA could produce such effects or neural death although symptoms of the serotonin syndrome occur [details reviewed by (Baumann et al, 2007)].…”
Section: Introductionmentioning
confidence: 99%