Repeated horizontal transfers of four DNA transposons in invertebrates and bats

Tang, Zhou; Zhang, Hua-Hao; Huang, Ke; Xiao-gu, Zhang; Han, Minjin; Zhang, Ze

doi:10.1186/s13100-014-0033-1

Cited by 34 publications

(28 citation statements)

References 46 publications

(59 reference statements)

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“…Interestingly, the implication of parasitoid insects as vector of HT of hAT and Ginger MITEs between R. prolixus and the silkworm B. mori has been proposed [ 10 ]. A similar situation has been reported between R. prolixus and the twisted wing parasite Mengenilla moldrzyki that are known to infect a large variety of insects [ 42 ]. In our dataset, we have detected a possible HT between the parasitic wasp S. oculata and R. prolixus .…”

Section: Resultssupporting

confidence: 71%

Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus

et al. 2015

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BackgroundThe Triatomine bug Rhodnius prolixus is a vector of Trypanosoma cruzi, which causes the Chagas disease in Latin America. R. prolixus can also transfer transposable elements horizontally across a wide range of species. We have taken advantage of the availability of the 700 Mbp complete genome sequence of R. prolixus to study the dynamics of invasion and persistence of transposable elements in this species.ResultsUsing both library-based and de novo methods of transposon detection, we found less than 6 % of transposable elements in the R. prolixus genome, a relatively low percentage compared to other insect genomes with a similar genome size. DNA transposons are surprisingly abundant and elements belonging to the mariner family are by far the most preponderant components of the mobile part of this genome with 11,015 mariner transposons that could be clustered in 89 groups (75 % of the mobilome). Our analysis allowed the detection of a new mariner clade in the R. prolixus genome, that we called nosferatis. We demonstrated that a large diversity of mariner elements invaded the genome and expanded successfully over time via three main processes. (i) several families experienced recent and massive expansion, for example an explosive burst of a single mariner family led to the generation of more than 8000 copies. These recent expansion events explain the unusual prevalence of mariner transposons in the R. prolixus genome. Other families expanded via older bursts of transposition demonstrating the long lasting permissibility of mariner transposons in the R. prolixus genome. (ii) Many non-autonomous families generated by internal deletions were also identified. Interestingly, two non autonomous families were generated by atypical recombinations (5' part replacement with 3' part). (iii) at least 10 cases of horizontal transfers were found, supporting the idea that host/vector relationships played a pivotal role in the transmission and subsequent persistence of transposable elements in this genome.ConclusionThese data provide a new insight into the evolution of transposons in the genomes of hematophagous insects and bring additional evidences that lateral exchanges of mobile genetics elements occur frequently in the R. prolixus genome.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-015-2060-9) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 71%

Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus

et al. 2015

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“…Of these, only retrotransposons are active in the modern human genome and represent a prominent force of genomic evolution [6,10], although other mammals, notably certain bat taxa, have much more diverse TE populations, including active DNA transposons [11,12]. Retrotransposons’ classification and molecular features are summarized in Figure 1; see previous reviews [6,13-15].…”

Section: Introductionmentioning

confidence: 99%

How retrotransposons shape genome regulation

Mita

Boeke

2016

Current Opinion in Genetics & Development

161

131

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Retrotransposons are mutagenic units able to move within the genome. Despite many defenses deployed by the host to suppress potentially harmful activities of retrotransposons, these genetic units have found ways to meld with normal cellular functions through processes of exaptation and domestication. The same host mechanisms targeting transposon mobility allow for expansion and rewiring of gene regulatory networks on an evolutionary time scale. Recent works demonstrating retrotransposon activity during development, cell differentiation and neurogenesis shed new light on unexpected activities of transposable elements. Moreover, new technological advances illuminated subtler nuances of the complex relationship between retrotransposons and the host genome, clarifying the role of retroelements in evolution, development and impact on human disease.

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“…Identifying HT events between similar species or individuals of the same species would give a better approximation for TE transfer frequency. Bats are frequently implicated as vectors of DNA exchange: they transmit numerous viruses and TEs, cause disease epidemics, and feed on arthropods (28)(29)(30). As such, they are the ideal intermediate species for horizontal transfer.…”

Section: Transfer Frequency and Mechanisms Differ Between Te Classesmentioning

confidence: 99%

Re-evaluating inheritance in genome evolution: widespread transfer of LINEs between species

Ivancevic

Kortschak

Bertozzi

et al. 2017

Preprint

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KeywordsGenome evolution, horizontal transfer, transposon, eukaryote, mammal not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/106914 doi: bioRxiv preprint first posted online Feb. 8, 2017; 3 Significance statement LINE-1 (L1) elements occupy about half of most mammalian genomes (1), and they are believed to be strictly vertically inherited (2). Mutagenic L1 insertions are thought to account for approximately 1 of every 1000 random, disease-causing insertions in humans (4-7). Our research indicates that the very presence of L1s in humans, and other therian mammals, is due to an ancient transfer event -which has drastic implications for our perception of genome evolution. Using a machina analyses over 503 genomes, we trace the origins of L1 and BovB retrotransposons across the tree of life, and provide evidence of their long-term impact on eukaryotic evolution. IntroductionTransposable elements (TEs) are mobile segments of DNA which occupy large portions of eukaryotic genomes, including more than half of the human genome (1). Long interspersed element (LINE) retrotransposons are TEs which move from site to site using a "copy and paste" mechanism, facilitating their amplification throughout the genome (3, 4). The insertion of retrotransposons can interrupt existing genetic structures, resulting in gene disruptions, chromosomal breaks and rearrangements, and numerous diseases such as cancer (5)(6)(7)(8). Two of the most abundant retrotransposon families in eukaryotes are LINE-1 (L1) and Bovine-B (BovB) (2, 9).Horizontal transfer (HT) is the transmission of genetic material by means other than parentto-offspring: a phenomenon primarily associated with prokaryotes. However, given a vector of transfer (e.g. virus, parasite), retrotransposons have the innate ability to jump between species as they do within genomes (3,10). Studies investigating the possibility of HT in not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/106914 doi: bioRxiv preprint first posted online Feb. 8, 2017; 4 retrotransposons are limited, mainly including CR1s and RTEs (9,(11)(12)(13). Given the limited evidence to date, we tested the hypothesis that horizontal transfer is a ubiquitous process not restricted to certain species or retrotransposons. We used L1 and BovB elements as exemplars because of their contrasting dynamics and predominance in mammalian genomes. BovB retrotransposons provide an excellent example of horizontal transfer: divergent species contain highly similar BovB sequences and the analysis of various tick species reveals a plausible vector of transfer (9). In contrast, L1 elements are believed to be only vertically inherited, based on knowledge gained primarily through mammalian organisms (2). We hypothesise that the very presence of L1s in today's mammals is due to an anci...

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Repeated horizontal transfers of four DNA transposons in invertebrates and bats

Cited by 34 publications

References 46 publications

Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus

Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus

How retrotransposons shape genome regulation

Re-evaluating inheritance in genome evolution: widespread transfer of LINEs between species

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