Repeated measurements of per- and polyfluoroalkyl substances (PFASs) from 1979 to 2007 in males from Northern Norway: Assessing time trends, compound correlations and relations to age/birth cohort

Abstract

Background Longitudinal biomonitoring studies can provide unique information on how human concentrations change over time, but have so far not been conducted for per-and polyfluoroalkyl substances (PFASs) in a background exposed population. Objectives Determine: i) serum PFAS time trends on an individual level; ii) relative compositions and correlations between different PFASs; and iii) assess selected PFAS concentrations with respect to periodic (calendar year), age and birth cohort (APC) effects. Methods

A review of sources, multimedia distribution and health risks of perfluoroalkyl acids (PFAAs) in China

“…For fetuses and infants, two exposure pathways of PFAAs, including maternal-fetal transmission and breast feeding transmission, have attracted intensive attention in recent years (So et al, 2006b;Tao et al, 2008;Liu et al, 2010;Glynn et al, 2012;Zhang et al, 2013a,d;Nøst et al, 2014). For fetuses, significant positive correlations have been found between concentrations of PFAAs in paired samples of maternal whole blood and placenta, and between placenta and cord blood (Zhang et al, 2013a) (Fig.…”

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

“…6), Gebbink et al [85] reported rapid declines (1.8-3.5 year disappearance half-lives) for four PFOS-precursors (MeFOSAA, EtFOSAA, FOSAA, FOSA) in the same period, between 1996 and 2012. Declining trends of the PFOS-precursor, FOSA, is furthermore demonstrated by analysis of two datasets on male serum from Norway, both of which showed an inverted U-shape temporal trend for FOSA [92,115]. For Norwegian men (40-50 year) [92], a significant increase of FOSA between 1977 and 1985 (change-point) was followed by a statistically significant decline to 2006, with later concentrations being non-detectable.…”

“…6). No significant temporal trends for PFOS were observed in only 6 datasets of human samples [89,102,115,121,143], and two datasets of dietary items [99,142], but in each case the power to detect a trend was low. Overall, the declining trends for PFOS generally coincide with the timing of the 3M Co. phase out by 2002.…”

“…For Norwegian men (40-50 year) [92], a significant increase of FOSA between 1977 and 1985 (change-point) was followed by a statistically significant decline to 2006, with later concentrations being non-detectable. In their longitudinal study of male serum, Nost et al [115] reported a significant 60% decline for FOSA between 2001 and 2007 in male serum from Tromso, Norway. Also, in Germany (Halle and Munster), declining concentrations of three PFOS-precursors (MeFOSAA, EtFOSAA, FOSAA) in human plasma were observed after 1995, whereas concentrations of another PFOS precursor (Di-SAm-PAP) showed no temporal trend at either location [145].…”

PFAS in Paper and Board for Food Contact

“…Nøst et al (2014) studied the temporal trends for exposure to PFAAs from 1979 to 2007 in males from Northern Norway. In five repeated measurements of PFAAs in human serum, they found that PFOA and PFOS concentrations peaked during 1994-2001 and 2001, respectively.…”