Repeated Rapid Shear-Responsiveness of Peptide Hydrogels with Tunable Shear Modulus

Ramachandran, Sivakumar; Tseng, Yiider; Yu, Yinan

doi:10.1021/bm049284w

Cited by 119 publications

(153 citation statements)

References 52 publications

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“…Decapeptides composed of an alternating charged/neutral amino acid pattern, were synthesized by Yu et al KVW10 and EVW10 consist of hydrophobic/neutral valine residues alternated with cationic lysine or anionic glutamic acid residues, respectively [471]. Either end of the decapeptide chains was capped by a functional group to remove any additional charged moieties that could impede self-assembly.…”

Section: Shear Stress Responsive Hydrogelsmentioning

confidence: 99%

“…However, when mixed together, self-assembly will occur because the mutual attraction between the charged residues of the peptides drives physical interaction. This behavior is independent of pH and ionic-strength, which is attractive for in vivo and in vitro applications, and will also occur at very low peptide concentrations [471,472]. Similar to the MITCH systems, these peptide hydrogels are capable of shear thinning because the physical interactions between the two charged peptide chains can be temporarily disrupted with applied force.…”

Section: Shear Stress Responsive Hydrogelsmentioning

confidence: 99%

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Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting

Peters

Steichen

et al. 2015

Materials Science and Engineering: R: Reports

923

688

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Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, allowing for more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. In this extensive review, we identify and discuss the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels. We discuss the theoretical analysis of hydrogel properties and the mechanisms used to create these responses, highlighting both the pioneering and most recent work in all of these fields. Finally, we review the many current and proposed applications of these hydrogels in medicine and industry.

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Section: Shear Stress Responsive Hydrogelsmentioning

confidence: 99%

Section: Shear Stress Responsive Hydrogelsmentioning

confidence: 99%

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting

Peters

Steichen

et al. 2015

Materials Science and Engineering: R: Reports

923

688

View full text Add to dashboard Cite

show abstract

“…Rapidly recoverable biomaterials can act as scaffolds for tissue engineering as they can accommodate cell growth while still maintaining their structure. 97 These matrices will provide cells with dynamic guidance cues that are important for tissue development. Dynamic in vitro culture devices that not only enhance nutrient diffusion and waste disposal but also impose physiologically relevant biomechanical and biophysical stimulations will further increase the chance for success.…”

Section: Force-induced Modulation Of Cellular Functionmentioning

confidence: 99%

Biomaterial-based strategies for the engineering of mechanically active soft tissues

Tong

Jia

2012

MRS Communications

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“…[7,[12][13][14]30] We therefore subjected the gels to a large amplitude deformation (> 10 000 Pa oscillatory stress) followed by a recovery period under small amplitude deformation conditions (< 50 Pa oscillatory stress). HPMA-based PBA-SHA crosslinked gels at pH 4.2 and AA-based PBA-SHA crosslinked gels at pH 7.6 demonstrated rehealing by the concentration-dependent recovery of G′ in time following failure (Fig.…”

mentioning

confidence: 99%

Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks

et al. 2007

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Nature provides many examples of soft gel-like materials where performance is determined by tuning time-dependent mechanical properties with dynamic bonding interactions between biomacromolecules.[1] Accordingly, synthetic gels that contain dynamic bonding interactions have undergone intense investigation in fundamental and applied material science. The balance of solid-like and fluid-like behavior in these gel networks results from the binding equilibrium of reversible crosslinks between polymer chains. [2][3][4][5] Contemporary research on gels has focused on self-assembled systems [6][7][8][9][10][11][12][13][14][15] usually exploiting hydrogen bonding interactions. However, gels crosslinked with reversible covalent bonding chemistries [16][17][18] would provide an energetically favorable, [19] specific and controlled mechanism for engineering functional dynamic networks. [20][21][22][23][24] We have synthesized hydrogel networks that form in the physiological pH range by the reversible covalent interaction of polymer-bound phenylboronic acid and salicylhydroxamic acid (Fig. 1). These gels demonstrate a spectrum of pH-dependent viscoelastic behavior that can be controlled by the chemical composition of the polymer backbone. Moreover, the reversible crosslinks allow these networks to restructure dynamically and self-heal after mechanical disruption. Phenylboronate-salicylhydroxamate gels provide a new class of self-assembled materials enabling precise control over network viscoelasticity and pH responsiveness. Water-soluble polymers containing 10 mol % phenylboronic acid (PBA) or 10 mol % salicylhydroxamic acid (SHA) were synthesized by free-radical polymerization of functionalized monomers with 2-hydroxypropylmethacrylamide (HPMA) or acrylic acid (AA; Fig. 1b). When aqueous solutions of PBA and SHA containing polymers are mixed at physiological pH, the PBA and SHA moieties associate to form coordinate covalent bonds [25][26][27] (PBA-SHA; Fig. 1a). c Figure 1. Self-healing, viscoelastic hydrogel networks are formed using reversible covalent crosslinking chemistry. a) Covalent bonds that form between polymer-bound phenylboronic acid (PBA) and salicylhydroxamic acid (SHA) have pH-dependent binding equilibria that are shifted to the uncrosslinked state under acidic conditions. b) Linear water-soluble polymers containing either PBA or SHA moieties can be easily synthesized with different polymer backbones (e.g., 2-hydroxypropylmethacrylamide (HPMA) or acrylic acid (AA)) of controlled molar feed ratios. Two degrees of substitution for each polymer were made with x = 90 mol % or 95 mol % (see Supporting Information Table S1 for details). c) When PBA-and SHA-containing polymer solutions are mixed under physiological conditions, a reversible semisolid gel forms due to the dynamic restructuring of the crosslinked gel network. The specific pH range at which gels behave reversibly can be controlled with choice of polymer backbone (in b); HPMA-based PBA-SHA crosslinked gels are reversible at mildly acidic pH (pH 4-5) whi...

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Repeated Rapid Shear-Responsiveness of Peptide Hydrogels with Tunable Shear Modulus

Cited by 119 publications

References 52 publications

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Biomaterial-based strategies for the engineering of mechanically active soft tissues

Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks

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